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Revision as of 02:58, 16 April 2014

Shock
Resident Survival Guide
Overview
Causes
FIRE
Diagnosis
Do's
Don'ts

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, MBChB. [2]

Overview

Shock is the syndrome of circulatory failure that results in inadequate cellular oxygen utilization. The diagnosis of shock is based on clinical signs (eg, altered mental status, oliguria, cold and clammy skin) and biochemical abnormalities (eg, hyperlactatemia) indicative of tissue hypoperfusion.[1] Management of shock consists of stabilization of the hemodynamic status and correction of the underlying cause.

Causes

Life Threatening Causes

Shock is a life-threatening condition and must be treated as such irrespective of the underlying cause.

Common Causes

Cardiogenic Shock
  • Arrhythmic
  • Mechanical
  • Myopathic
  • Pharmacologic
Obstructive Shock
  • Decreased cardiac compliance
  • Decreased ventricular preload
  • Increased ventricular afterload
Hypovolemic Shock
  • Fluid depletion
  • Hemorrhage
Distributive Shock

Click here for the complete list of causes.

FIRE: Focused Initial Rapid Evaluation

A Focused Initial Rapid Evaluation (FIRE) should be performed to identify patients in need of immediate intervention.

Boxes in the salmon color signify that an urgent management is needed.

Abbreviations: CBC, complete blood count; CI, cardiac index; CK-MB, creatine kinase MB isoform; CVP, central venous pressure; DC, differential count; ICU, intensive care unit; INR, international normalized ratio; LFT, liver function test; MAP, mean arterial pressure; MVO2, mixed venous oxygen saturation; PCWP, pulmonary capillary wedge pressure; PT, prothrombin time; PTT, partial prothrombin time; SaO2, arterial oxygen saturation; SBP, systolic blood pressure; SCVO2, central venous oxygen saturation; SMA-7, sequential multiple analysis-7.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
Does the patient have cardinal findings that increase the pretest probability of shock?

❑  Arterial hypotension

❑  SBP <90 mm Hg or
❑  MAP <70 mm Hg

❑  + Signs of hypoperfusion

❑  Altered mental status
❑  Cold, clammy skin
❑  Oliguria
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
YES
 
 
 
 
 
 
 
 
 
 
NO
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Consider other causes (eg, chronic hypotension, syncope)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Initial investigation
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
History of trauma?
 
YES, then consider

❑  Cardiac injury

❑  Cardiac tamponade

❑  Hemorrhagic shock

❑  Tension pneumothorax

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
NO, then proceed to the next step
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Evidence of gastrointestinal hemorrhage, vomiting, diarrhea?
 
YES, then consider and manage as hypovolemic shock
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
NO, then proceed to the next step
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Fever or hypothermia?
 
YES, then consider and manage as septic shock
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
NO, then proceed to the next step
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Ischemic findings on ECG and/or chest pain with coronary risk factors?
 
YES, then consider and manage as cardiogenic shock
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
NO, then proceed to the next step
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Unexplained bradycardia?
 
YES, then consider

❑  Negative inotropic agents

❑  Hypothyroidism

❑  Steroid withdrawal

❑  Adrenal crisis

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
NO, then proceed to the next step
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Unexplained hypoxemia?
 
YES, then consider acute pulmonary embolism
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
NO, then proceed to the next step
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Abdominal or low back pain?
 
YES, then consider abdominal processes and surgical consultation
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
NO, then proceed to the next step
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Wheezing with hives or skin flushing?
 
YES, then consider abdominal processes and surgical consultation
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
NO, then proceed to
complete diagnostic approach below

Complete Diagnostic Approach

 

History

Review all medications

❑  Antihypertensives can cause significant hypotension, especially in the setting of volume depletion or over-diuresis.
❑  Anaphylaxis should be considered if the patient recently started on a new drug and presented with respiratory distress.

Findings suggestive of hypovolemic shock

❑  Abdominal pain
❑  Diarrhea
❑  Dry skin, mucosa, axillae
❑  Hematemesis
❑  Hematochezia
❑  Melena
❑  Postoperative
❑  Trauma
❑  Vomiting

Findings suggestive of cardiogenic shock

❑  Chest pain
❑  Dyspnea
❑  Palpitations

Findings suggestive of distributive shock

❑  Altered mental status
❑  Chills
❑  Dyspnea
❑  Dysuria
❑  Fatigue
❑  Fever
❑  Flushing
❑  Headache
❑  Hematuria
❑  Malaise
❑  Myalgias
❑  Photophobia
❑  Productive cough
❑  Rash
❑  Tachycardia
❑  Tachypnea
 
 
 
 
 
 

Physical Examination

Vital signs

❑  Temperature
❑  Fever may suggest sepsis or anaphylactic reaction related to transfusion.
❑  Hypothermia may be associated with sepsis, adrenal crisis, or myxedema.
❑  Pulse
❑  Bradycardia or tachycardia can either be a primary or secondary process.
❑  Pulsus paradoxus may be seen in cardiac tamponade, pulmonary embolism, hemorrhagic shock, or tension pneumothorax.
❑  Pulsus alternans may be seen in heart failure, severe aortic insufficiency, or hypovolemic shock.
❑  Respiration
❑  Tachypnea commonly occurs in pneumothorax, sepsis, and cardiogenic shock.
❑  Hypopnea may be seen in narcotic or sedative overdose.
❑  Blood pressure
❑  Confirm arterial hypotension by checking blood pressure in both arms manually. Arterial line may be considered.
❑  Postural hypotension suggests volume depletion or autonomic dysfunction. Do not test orthostatic hypotension in hypotensive patients.

Mental status

❑  Altered mental status may indicate inadequate perfusion to vital organs or use of sedatives or narcotics.

Cutaneous

❑  Decreased skin turgor and dry mucous membrane signify dehydration.
❑  Cool extremities, clammy and mottled skin, peripheral cyanosis, and delayed capillary refill are commonly noted in cardiogenic shock and hypovolemic shock, whereas warm and moist skin may represent hyperdynamic phase of septic shock.
❑  Extensive burns and severe trauma may be evident on inspection and are associated with significant fluid loss.
❑  Hyperpigmentation may be an indicator of adrenal crisis.

Neck

❑  Elevated JVP
❑  Heart failure
❑  Tricuspid stenosis
❑  Pulmonary hypertension
❑  Superior vena cava obstruction
❑  Constrictive pericarditis
❑  Cardiac tamponade
❑  Kussmaul's sign
❑  Constrictive pericarditis
❑  Restrictive cardiomyopathy
❑  Tricuspid stenosis
❑  Superior vena cava obstruction
❑  Right ventricular infarction
❑  Abdominojugular reflux (a positive abdominojugular reflux correlates with a PCWP of 15 mmHg or greater)
❑  Cardiac tamponade
❑  Constrictive pericarditis
❑  Tricuspid insufficiency
❑  Inferior vena cava obstruction
❑  Heart failure (except for pure backward left-sided heart failure)
❑  Jugular venous pressure waveform
❑  Blunted y descent suggests cardiac tamponade or tricuspid stenosis.
❑  Steep y descent suggests constrictive pericarditis or severe tricuspid insufficiency.

Cardiovascular

❑  Decrescendo early systolic murmur
❑  Acute severe mitral regurgitation
❑  Third heart sound (S3)
❑  Heart failure
❑  Pansystolic murmur along lower left sternal border with palpable thrill
❑  Ventricular septal defect
❑  Pericardial friction rubs
❑  Pericarditis
❑  Distant, muffled heart sounds
❑  Cardiac tamponade

Pulmonary

❑  Tracheal deviation
❑  Tension pneumothorax
❑  Stridor and wheezing
❑  Anaphylaxis
❑  Acute exacerbation of chronic obstructive pulmonary disease
❑  Rales
❑  Anaphylaxis
❑  Pneumonia
❑  Heart failure
❑  Chest percussion may aid in the diagnosis of tension pneumothorax, pleural effusions, and pneumonia

Abdominal

❑  Grey Turner's sign
❑  Acute pancreatitis
❑  Blunt abdominal trauma
❑  Retroperitoneal hemorrhage
❑  Ruptured abdominal aortic aneurysm
❑  Ruptured ectopic pregnancy
❑  Cullen's sign
❑  Acute pancreatitis
❑  Blunt abdominal trauma
❑  Ruptured abdominal aortic aneurysm
❑  Ruptured ectopic pregnancy
❑  Hepatomegaly
❑  Inferior vena cava obstruction
❑  Heart failure
❑  Rebound tenderness with absent bowel sounds
❑  Sepsis due to Intraabdominal infection
❑  Ischemic colitis
❑  Gastrointestinal hemorrhage
❑  Pulsatile mass
❑  Abdominal aortic aneurysm

Rectal

❑  Bright red blood or melena
❑  Gastrointestinal hemorrhage
❑  Diminished sphincter tone
❑  Spinal cord injury

Extremities

❑  Digital clubbing
❑  Heart failure
❑  Edema
❑  Heart failure
❑  Erythema at the site of venous access
❑  Catheter-associated infection
❑  Pelvic girdle pain or instability
❑  Pelvic fracture

Genitals

❑  Perform a pelvic examination in women of childbearing age to rule out ectopic pregnancy or pelvic inflammatory disease.

Neurologic

❑  Agitation or delirium
❑  Poor cerebral perfusion
❑  Meningeal signs (nuchal rigidity, Brudzinski sign, and Kernig sign)
❑  Meningitis
 
 
 
 
 
 

Laboratory Findings

Complete blood count

❑  In acute blood loss, hemoglobin and hematocrit levels may remain normal until volume repletion.
❑  Leukocytosis with or without a left shift of neutrophils suggests sepsis.
❑  Thrombocytopenia with alterations in coagulation panel indicates disseminated intravascular coagulation (DIC), which may be a complication of sepsis.

Electrolytes

❑  Decreased bicarbonate levels may be the primary deficit in metabolic acidosis or the compensatory change in respiratory alkalosis.
❑  Hyperkalemia due to transcellular shift is commonly associated with metabolic acidosis.

Coagulation panel (PT, PTT, INR, etc.)

❑  Abnormalities in coagulation panel may be caused by disseminated intravascular coagulation (DIC), over-anticoagulation, or hepatic failure.

Cardiac markers

❑  Check troponin and CK-MB levels when suspecting myocardial infarction.
❑  Elevation in cardiac markers may be associated with both cardiac and extracardiac etiologies.

Liver function

❑  Increased levels of conjugated bilirubin, alkaline phosphatase, and aminotransferases are typically seen in ischemic hepatitis ("shock liver") due to cardiogenic shock.

Renal function

❑  Prerenal azotemia and/or acute tubular necrosis may be associated with conditions of hypovolemia or reduced cardiac output.
❑  Oliguria (urine output <0.5 mL/kg/h) is usually evident.

Lactate

❑  Hyperlactatemia generally reflects the development of anaerobic metabolism in hypoperfused tissue and/or imparied hepatic clearance.
❑  Lactate level could decrease within hours with effective therapy.[1]

Amylase and lipase

❑  Elevated amylase and lipase levels are suggestive of acute pancreatitis.

Arterial blood gas

❑  Lactic acidosis may be an indicator of tissue hypoperfusion typically seen in septic shock.
❑  Combined acid-base disorders are fequently encountered in different stages of shock.
❑  Severe acidosis could blunt the effectiveness of vasopressors and potentiate the development of arrhythmias.

Cultures

❑  Samples of blood, urine, and/or sputum should be sent for culture before administering antibiotics if sepsis is concerned.

Nasogastric aspirate

❑  A negative nasogastric aspirate does not rule out upper gastrointestinal bleeding.

Pregnancy test

❑  A pregnancy test should be performed on hypotensive women of childbearing age presenting with lower abdominal pain.
 
 
 
 
 
 

ECG Findings

❑  ST segment elevation or depression, pathologic Q waves, hyperacute or negative T waves

❑  Myocardial infarction or ischemia

❑  Sinus tachycardia with S1Q3T3 pattern

❑  Acute pulmonary embolism

❑  Low QRS voltage with electrical alternans

❑  Cardiac tamponade

❑  QS deflections in precordial leads with right axis deviation and low QRS voltage

❑  Pneumothorax

❑  Bradyarrhythmias or tachyarrhythmias

Radiographic Findings

❑  Chest radiograph may aid in establishing diagnosis in the following conditions:

❑  Aortic dissection
❑  Cardiac tamponade
❑  Pneumonia complicating septic shock
❑  Pulmonary edema complicating cardiogenic shock
❑  Tension pneumothorax

❑  CT scan may aid in directing management in the following conditions:

❑  Occult internal hemorrhage
❑  Pulmonary embolism
 
 
 
 
 
 

Hemodynamic Profiles and Echocardiography Findings

Type of Shock Etiology CO SVR PCWP CVP SVO2 Echocardiographic Findings
Cardiogenic Acute Ventricular Septal Defect ↓↓ N — ↑ ↑↑ ↑ — ↑↑ Large ventricles with poor contractility
Acute Mitral Regurgitation ↓↓ ↑↑ ↑ — ↑↑
Myocardial Dysfunction ↓↓ ↑↑ ↑↑
RV Infarction ↓↓ N — ↓ ↑↑ Dilated RV, small LV, abnormal wall motions
Obstructive Pulmonary Embolism ↓↓ N — ↓ ↑↑ Dilated RV, small LV
Cardiac Tamponade ↓ — ↓↓ ↑↑ ↑↑ Pericardial effusion, small ventricles, dilated inferior vena cava
Distributive Septic Shock N — ↑↑ ↓ — ↓↓ N — ↓ N — ↓ ↑ — ↑↑ Normal cardiac chambers with preserved contractility
Anaphylactic Shock N — ↑↑ ↓ — ↓↓ N — ↓ N — ↓ ↑ — ↑↑
Hypovolemic Volume Depletion ↓↓ ↓↓ ↓↓ Small cardiac chambers with normal or high contractility

Treatment

Management of shock consists of stabilization of the hemodynamic status and correction of the underlying cause once it is identified.

Cardiogenic shock

Obstructive shock

Distributive shock

Hypovolemic shock

Do's

  • Initial Management
  • Resuscitation should be initiated while investigation is ongoing. Correct the cause of shock immediately once it is identified.
  • The VIP (Ventilate-Infuse-Pump) approach is useful for ensuring an orderly sequence of therapeutic-diagnostic maneuvers.[2]
  • Ventilate
  • Infuse
  • Pump

Don'ts

References

  1. 1.0 1.1 Vincent, JL.; De Backer, D. (2013). "Circulatory shock". N Engl J Med. 369 (18): 1726–34. doi:10.1056/NEJMra1208943. PMID 24171518. Unknown parameter |month= ignored (help)
  2. Weil, MH.; Shubin, H. (1969). "The VIP approach to the bedside management of shock". JAMA. 207 (2): 337–40. PMID 5818156. Unknown parameter |month= ignored (help)
  3. Dellinger, RP.; Levy, MM.; Rhodes, A.; Annane, D.; Gerlach, H.; Opal, SM.; Sevransky, JE.; Sprung, CL.; Douglas, IS. (2013). "Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012". Crit Care Med. 41 (2): 580–637. doi:10.1097/CCM.0b013e31827e83af. PMID 23353941. Unknown parameter |month= ignored (help)