Intravenous fluid

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Intravenous fluid

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Intravenous Fluid

There are two types of fluids that are used for intravenous drips; crystalloids and colloids. Crystalloids are aqueous solutions of mineral salts or other water-soluble molecules. Colloids contain larger insoluble molecules, such as gelatin; blood itself is a colloid.

The most commonly used crystalloid fluid is normal saline, a solution of sodium chloride at 0.9% concentration, which is close to the concentration in the blood (isotonic). Ringer's lactate or Ringer's acetate (ASERING, patented brandname of Otsuka Indonesia) is another isotonic solution often used for large-volume fluid replacement. A solution of 5% dextrose in water, sometimes called D5W, is often used instead if the patient is at risk for having low blood sugar or high sodium. The choice of fluids may also depend on the chemical properties of the medications being given.

Intravenous fluids must always be sterile.

Crystalloid Fluids

Composition of Common Crystalloid Solutions
Solution Other Name [Na+](mmol/L) [Cl-](mmol/L) [Glucose](mmol/L) [Glucose](mg/dl)
D5W 5% Dextrose 0 0 278 5000
2/3D & 1/3S 3.3% Dextrose / 0.3% saline 51 51 185 3333
Half-normal saline 0.45% NaCl 77 77 0 0
Normal saline 0.9% NaCl 154 154 0 0
Ringer's lactate Lactated Ringer 130 109 0 0

Ringer's lactate also has 28 mmol/L lactate, 4 mmol/L K+ and 3 mmol/L Ca2+. Ringer's acetate (ASERING) also has 28 mmol/L acetate, 4 mmol/L K+ and 3 mmol/L Ca2+.

Effect of Adding One Litre
Solution Change in ECF Change in ICF
D5W 333 mL 667 mL
2/3D & 1/3S 556 mL 444 mL
Half-normal saline 667 mL 333 mL
Normal saline 1000 mL 0 mL
Ringer's lactate 900 mL 100 mL

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