Acute tubular necrosis
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| Acute tubular necrosis Classification and external resources | |
| ICD-10 | N17.0 |
|---|---|
| ICD-9 | 584.5 |
| DiseasesDB | 11263 |
| eMedicine | med/39 ped/28 |
| MeSH | D007683 |
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Overview
Acute tubular necrosis or (ATN) is a medical condition involving the death of tubular cells that form the tubule that transports urine to the ureters while reabsorbing 99% of the water (and highly concentrating the salts and metabolic byproducts). Tubular cells continually replace themselves and if the cause of Acute Tubular Necrosis is removed then recovery is likely. ATN presents with acute renal failure and is one of the most common causes of ARF. The presence of "muddy brown casts" of epithelial cells found in the urine during urinalysis is pathognomonic for Acute Tubular Necrosis.
It may be classified as either toxic or ischemic. Toxic Acute Tubular Necrosis occurs when the tubular cells are exposed to a toxic substance (nephrotoxic Acute Tubular Necrosis). Ischemic Acute Tubular Necrosis occurs when the tubular cells do not get enough oxygen, a condition they are highly sensitive to due to their very high metabolism.
Toxic Acute Tubular Necrosis
Toxic ATN can be caused by free hemoglobin or myoglobin, by medication such as antibiotics and cytostatic drugs, or by intoxication (ethylene glycol, "anti-freeze").
Histopathology: Toxic ATN is characterized by proximal tubular epithelium necrosis (no nuclei, intense eosinophilic homogeneous cytoplasm, but preserved shape) due to a toxic substance (poisons, organic solvents, drugs, heavy metals). Necrotic cells fall into the tubule lumen, obliterating it, and determining acute renal failure. Basement membrane is intact, so the tubular epithelium regeneration is possible. Glomeruli are not affected.
Ischemic Acute Tubular Necrosis
Ischemic Acute Tubular Necrosis can be caused when the kidneys are not sufficiently perfused for a long period of time (i.e. renal artery stenosis) or during shock. Hypoperfusion can also be caused by embolism of the renal arteries. Ischemic Acute Tubular Necrosis specifically causes skip lesions through the tubules.
External links
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
