Isoproterenol

Jump to: navigation, search
Isoproterenol.png
Isoproterenol
Systematic (IUPAC) name
4-[1-hydroxy-2-(1-methylethylamino) ethyl] benzene-1,2-diol
Identifiers
CAS number 7683-59-2
ATC code C01CA02 R03AB02
PubChem 3779
DrugBank APRD00182
Chemical data
Formula C11H17NO3 
Mol. mass 211.258 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes inhaled 80-120μg

WikiDoc Resources for

Isoproterenol

Articles

Most recent articles on Isoproterenol

Most cited articles on Isoproterenol

Review articles on Isoproterenol

Articles on Isoproterenol in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Isoproterenol

Images of Isoproterenol

Photos of Isoproterenol

Podcasts & MP3s on Isoproterenol

Videos on Isoproterenol

Evidence Based Medicine

Cochrane Collaboration on Isoproterenol

Bandolier on Isoproterenol

TRIP on Isoproterenol

Clinical Trials

Ongoing Trials on Isoproterenol at Clinical Trials.gov

Trial results on Isoproterenol

Clinical Trials on Isoproterenol at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Isoproterenol

NICE Guidance on Isoproterenol

NHS PRODIGY Guidance

FDA on Isoproterenol

CDC on Isoproterenol

Books

Books on Isoproterenol

News

Isoproterenol in the news

Be alerted to news on Isoproterenol

News trends on Isoproterenol

Commentary

Blogs on Isoproterenol

Definitions

Definitions of Isoproterenol

Patient Resources / Community

Patient resources on Isoproterenol

Discussion groups on Isoproterenol

Patient Handouts on Isoproterenol

Directions to Hospitals Treating Isoproterenol

Risk calculators and risk factors for Isoproterenol

Healthcare Provider Resources

Symptoms of Isoproterenol

Causes & Risk Factors for Isoproterenol

Diagnostic studies for Isoproterenol

Treatment of Isoproterenol

Continuing Medical Education (CME)

CME Programs on Isoproterenol

International

Isoproterenol en Espanol

Isoproterenol en Francais

Business

Isoproterenol in the Marketplace

Patents on Isoproterenol

Experimental / Informatics

List of terms related to Isoproterenol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Isoproterenol hydrochloride or isoprenaline (Medihaler-Iso®) is a sympathomimetic beta adrenergic receptor agonist medication.

It is structurally similar to epinephrine but acts for the most part on beta receptors.

Uses

It is used as an inhaled aerosol to treat asthma. Although it activates all beta adrenergic receptors, it works in a similar fashion to the more selective beta2-adrenergic receptor agonists e.g. salbutamol, by relaxing the airways to increase airflow.

It is also supplied in ampules under the brand name Isuprel® for injection and in sublingual pill form for treatment of asthma, chronic bronchitis and emphysema.

Used with caution, it can also be used to treat torsades de pointes, in conjunction with overdrive pacing and magnesium.

Pharmacology

Isoproterenol is a β1- and β2-adrenoceptor agonist which was commonly used to treat asthma before the more widespread use of salbutamol, which has more selective effects on the airways. Its route of administration is either intravenous, oral, intranasal, subcutaneous, or intramuscular, depending on use. The plasma half-life for isoproterenol is approximately two hours.

Isoproterenol's effects on the cardiovascular system relate to its actions on cardiac β1 receptors and β2 receptors on skeletal muscle arterioles. Isoproterenol has positive inotropic and chronotropic effects on the heart. In skeletal muscle arterioles it produces vasodilatation. Its inotropic and chronotropic effects elevate systolic blood pressure, while its vasodilatory effects tend to lower diastolic blood pressure.

The adverse effects of isoproterenol are also related to the drug's cardiovascular effects. Isoproterenol can produce an elevated heart rate (tachycardia), which predisposes patients to cardiac dysrhythmias.

Warnings and Contraindications

Isoproterenol should not be administered to patients with myocardial ischaemia.


Linked-in.jpg