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===Substrates of Cytochrome P-450 Isozymes=== | ===Substrates of Cytochrome P-450 Isozymes=== | ||
====CYP1A2==== | <div style="font-size: 12px; font-family: Arial;">{{columns-list| | ||
====CYP1A2 {{ID-returntotop}}==== | |||
* [[Amitriptyline]] | * [[Amitriptyline]] | ||
* [[Caffeine]] | * [[Caffeine]] | ||
| Line 22: | Line 25: | ||
* [[Tizanidine]] | * [[Tizanidine]] | ||
* [[Verapamil]] | * [[Verapamil]] | ||
* [[Warfarin]] | * [[Warfarin|R-warfarin]] | ||
* [[Zileuton]] | * [[Zileuton]] | ||
* [[Zolmitriptan]] | * [[Zolmitriptan]] | ||
====CYP2B6==== | ====CYP2B6 {{ID-returntotop}}==== | ||
* [[Bupropion]] | * [[Bupropion]] | ||
* [[Cyclophosphamide]] | * [[Cyclophosphamide]] | ||
| Line 33: | Line 37: | ||
* [[Methadone]] | * [[Methadone]] | ||
====CYP2C8==== | ====CYP2C8 {{ID-returntotop}}==== | ||
* [[Amodiaquine]] | |||
* [[Cerivastatin]] | |||
* [[Paclitaxel]] | |||
* [[Torsemide]] | |||
* [[Repaglinide]] | |||
====CYP2C9 {{ID-returntotop}}==== | |||
* [[Amitriptyline]] | |||
* [[Celecoxib]] | |||
* [[Diclofenac]] | |||
* [[Fluoxetine]] | |||
* [[Fluvastatin]] | |||
* [[Glipizide]] | |||
* [[Glyburide]] | |||
* [[Ibuprofen]] | |||
* [[Irbesartan]] | |||
* [[Lornoxicam]] | |||
* [[Losartan]] | |||
* [[Meloxicam]] | |||
* [[Nateglinide]] | |||
* [[Omeprazole]] | |||
* [[Phenytoin]] | |||
* [[Piroxicam]] | |||
* [[Rosiglitazone]] | |||
* [[Rosuvastatin]] | |||
* [[Warfarin|S-warfarin]] | |||
* [[Tamoxifen]] | |||
* [[Tolbutamide]] | |||
* [[Torsemide]] | |||
====CYP2C19 {{ID-returntotop}}==== | |||
* [[Carisoprodol]] | |||
* [[Chloramphenicol]] | |||
* [[Citalopram]] | |||
* [[Clomipramine]] | |||
* [[Cyclophosphamide]] | |||
* [[Esomeprazole]] | |||
* [[Hexobarbital]] | |||
* [[Indomethacin]] | |||
* [[Lansoprazole]] | |||
* [[Moclobemide]] | |||
* [[Nelfinavir]] | |||
* [[Nilutamide]] | |||
* [[Omeprazole]] | |||
* [[Pantoprazole]] | |||
* [[Phenobarbital]] | |||
* [[Phenytoin]] | |||
* [[Primidone]] | |||
* [[Progesterone]] | |||
* [[Proguanil]] | |||
* [[Propranolol]] | |||
* [[Rabeprazole]] | |||
* [[Teniposide]] | |||
* [[Voriconazole]] | |||
====CYP2D6 {{ID-returntotop}}==== | |||
* [[Alprenolol]] | |||
* [[Amitriptyline]] | |||
* [[Amphetamine]] | |||
* [[Aripiprazole]] | |||
* [[Atomoxetine]] | |||
* [[Carvedilol]] | |||
* [[Chlorpheniramine]] | |||
* [[Chlorpromazine]] | |||
* [[Clomipramine]] | |||
* [[Codeine]] | |||
* [[Debrisoquine]] | |||
* [[Desipramine]] | |||
* [[Dexfenfluramine]] | |||
* [[Dextromethorphan]] | |||
* [[Duloxetine]] | |||
* [[Encainide]] | |||
* [[Flecainide]] | |||
* [[Fluoxetine]] | |||
* [[Fluvoxamine]] | |||
* [[Haloperidol]] | |||
* [[Imipramine]] | |||
* [[Lidocaine]] | |||
* [[Metoclopramide]] | |||
* [[Paroxetine]] | |||
* [[Perphenazine]] | |||
* [[Propafenone]] | |||
* [[metoprolol|S-metoprolol]] | |||
* [[Thioridazine]] | |||
* [[Timolol]] | |||
====CYP2E1 {{ID-returntotop}}==== | |||
* [[Acetaminophen]] | |||
* [[Chlorzoxazone]] | |||
* [[Enflurane]] | |||
* [[Ethanol]] | |||
* [[Halothane]] | |||
* [[Isoflurane]] | |||
* [[Methoxyflurane]] | |||
* [[Sevoflurane]] | |||
====CYP3A {{ID-returntotop}}==== | |||
* [[Alfentanil]] | |||
* [[Alprazolam]] | |||
* [[Amlodipine]] | |||
* [[Aprepitant]] | |||
* [[Aripiprazole]] | |||
* [[Artemisinin]] | |||
* [[Astemizole]] | |||
* [[Atazanavir]] | |||
* [[Atorvastatin]] | |||
* [[Boceprevir]] | |||
* [[Buspirone]] | |||
* [[Cafergot]] | |||
* [[Chlorpheniramine]] | |||
* [[Cilostazol]] | |||
* [[Clarithromycin]] | |||
* [[Cocaine]] | |||
* [[Cyclosporine]] | |||
* [[Dapsone]] | |||
* [[Darunavir]] | |||
* [[Dexamethasone]] | |||
* [[Dextromethorphan]] | |||
* [[Diltiazem]] | |||
* [[Docetaxel]] | |||
* [[Domperidone]] | |||
* [[Eplerenone]] | |||
* [[Erythromycin]] | |||
* [[Estradiol]] | |||
* [[Etravirine]] | |||
* [[Felodipine]] | |||
* [[Fentanyl]] | |||
* [[Finasteride]] | |||
* [[Fosamprenavir]] | |||
* [[Haloperidol]] | |||
* [[Hydrocortisone]] | |||
* [[Imatinib]] | |||
* [[Indinavir]] | |||
* [[Irinotecan]] | |||
* [[Lidocaine]] | |||
* [[Lovastatin]] | |||
* [[Midazolam]] | |||
* [[Nateglinide]] | |||
* [[Nelfinavir]] | |||
* [[Nifedipine]] | |||
* [[Nisoldipine]] | |||
* [[Nitrendipine]] | |||
* [[Ondansetron]] | |||
* [[Pimozide]] | |||
* [[Progesterone]] | |||
* [[Quetiapine]] | |||
* [[Quinidine]] | |||
* [[Quinine]] | |||
* [[Risperidone]] | |||
* [[Ritonavir]] | |||
* [[Salmeterol]] | |||
* [[Saquinavir]] | |||
* [[Sildenafil]] | |||
* [[Simvastatin]] | |||
* [[Sirolimus]] | |||
* [[Tacrolimus]] | |||
* [[Tadalafil]] | |||
* [[Taxol]] | |||
* [[Telaprevir]] | |||
* [[Telithromycin]] | |||
* [[Terfenadine]] | |||
* [[Testosterone]] | |||
* [[Tipranavir]] | |||
* [[Trazodone]] | |||
* [[Triazolam]] | |||
* [[Troleandomycin]] | |||
* [[Vardenafil]] | |||
* [[Verapamil]] | |||
* [[Vincristine]] | |||
* [[Zaleplon]] | |||
* [[Ziprasidone]] | |||
* [[Zolpidem]] | |||
}}</div> | |||
===Inhibitors of Cytochrome P-450 Isozymes=== | |||
<div style="font-size: 12px; font-family: Arial;">{{columns-list| | |||
====CYP1A2 {{ID-returntotop}}==== | |||
* [[Amiodarone]] | |||
* [[Cimetidine]] | |||
* [[Ciprofloxacin]] | |||
* [[Fluvoxamine]] | |||
* [[Interferon]] | |||
* [[Methoxsalen]] | |||
==== | ====CYP2B6 {{ID-returntotop}}==== | ||
* [[Ticlopidine]] | |||
* [[Thiotepa]] | |||
==== | ====CYP2C8 {{ID-returntotop}}==== | ||
* [[Gemfibrozil]] | |||
* [[Montelukast]] | |||
* [[Pioglitazone]] | |||
* [[Quercetin]] | |||
* [[Rosiglitazone]] | |||
* [[Trimethoprim]] | |||
==== | ====CYP2C9 {{ID-returntotop}}==== | ||
* [[Amiodarone]] | |||
* [[Fenofibrate]] | |||
* [[Fluconazole]] | |||
* [[Fluvastatin]] | |||
* [[Fluvoxamine]] | |||
* [[Isoniazid]] | |||
* [[Probenecid]] | |||
* [[Sertraline]] | |||
* [[Sulfamethoxazole]] | |||
* [[Teniposide]] | |||
* [[Voriconazole]] | |||
* [[Zafirlukast]] | |||
==== | ====CYP2C19 {{ID-returntotop}}==== | ||
* [[Cimetidine]] | |||
* [[Esomeprazole]] | |||
* [[Felbamate]] | |||
* [[Fluoxetine]] | |||
* [[Fluvoxamine]] | |||
* [[Indomethacin]] | |||
* [[Ketoconazole]] | |||
* [[Lansoprazole]] | |||
* [[Modafinil]] | |||
* [[Omeprazole]] | |||
* [[Oxcarbazepine]] | |||
* [[Pantoprazole]] | |||
* [[Probenecid]] | |||
* [[Rabeprazole]] | |||
* [[Ticlopidine]] | |||
* [[Topiramate]] | |||
====CYP2D6 {{ID-returntotop}}==== | |||
* [[Amiodarone]] | |||
* [[Bupropion]] | |||
* [[Celecoxib]] | |||
* [[Chlorpheniramine]] | |||
* [[Chlorpromazine]] | |||
* [[Cimetidine]] | |||
* [[Citalopram]] | |||
* [[Clemastine]] | |||
* [[Clomipramine]] | |||
* [[Cocaine]] | |||
* [[Diphenhydramine]] | |||
* [[Doxepin]] | |||
* [[Doxorubicin]] | |||
* [[Duloxetine]] | |||
* [[Escitalopram]] | |||
* [[Fluoxetine]] | |||
* [[Halofantrine]] | |||
* [[Hydroxyzine]] | |||
* [[Metoclopramide]] | |||
* [[Mibefradil]] | |||
* [[Midodrine]] | |||
* [[Moclobemide]] | |||
* [[Paroxetine]] | |||
* [[Perphenazine]] | |||
* [[Quinidine]] | |||
* [[Ranitidine]] | |||
* [[Ritonavir]] | |||
* [[Sertraline]] | |||
* [[Terbinafine]] | |||
* [[Ticlopidine]] | |||
====CYP2E1 {{ID-returntotop}}==== | |||
* [[Disulfiram]] | |||
====CYP3A {{ID-returntotop}}==== | |||
* [[Amiodarone]] | |||
* [[Aprepitant]] | |||
* [[Cimetidine]] | |||
* [[Clarithromycin]] | |||
* [[Cobicistat]] | |||
* [[Delavirdine]] | |||
* [[Diltiazem]] | |||
* [[Elvitegravir]] | |||
* [[Erythromycin]] | |||
* [[Fluconazole]] | |||
* [[Fluvoxamine]] | |||
* [[Gestodene]] | |||
* [[Imatinib]] | |||
* [[Indinavir]] | |||
* [[Itraconazole]] | |||
* [[Ketoconazole]] | |||
* [[Mibefradil]] | |||
* [[Mifepristone]] | |||
* [[Nefazodone]] | |||
* [[Nelfinavir]] | |||
* [[Norfloxacin]] | |||
* [[Norfluoxetine]] | |||
* [[Posaconazole]] | |||
* [[Ritonavir]] | |||
* [[Saquinavir]] | |||
* [[Telithromycin]] | |||
* [[Verapamil]] | |||
* [[Voriconazole]] | |||
}}</div> | |||
===Inducers of Cytochrome P-450 Isozymes=== | |||
<div style="font-size: 12px; font-family: Arial;">{{columns-list| | |||
====CYP1A2 {{ID-returntotop}}==== | |||
* [[Nicotine]] | |||
* [[Marijuana]] | |||
* [[Modafinil]] | |||
* [[Nafcillin]] | |||
====CYP2B6 {{ID-returntotop}}==== | |||
* [[Phenobarbital]] | |||
* [[Rifampin]] | |||
====CYP2C8 {{ID-returntotop}}==== | |||
* [[Rifampin]] | |||
====CYP2C9 {{ID-returntotop}}==== | |||
* [[Rifampin]] | |||
* [[Secobarbital]] | |||
====CYP2C19 {{ID-returntotop}}==== | |||
* [[Carbamazepine]] | |||
* [[Norethindrone]] | |||
* [[Prednisone]] | |||
* [[Rifampin]] | |||
====CYP2D6 {{ID-returntotop}}==== | |||
* [[Dexamethasone]] | |||
* [[Rifampin]] | |||
====CYP2E1 {{ID-returntotop}}==== | |||
* [[Ethanol]] | |||
* [[Isoniazid]] | |||
====CYP3A {{ID-returntotop}}==== | |||
* [[Barbiturates]] | |||
* [[Carbamazepine]] | |||
* [[Efavirenz]] | |||
* [[Glucocorticoids]] | |||
* [[Modafinil]] | |||
* [[Nevirapine]] | |||
* [[Oxcarbazepine]] | |||
* [[Phenobarbital]] | |||
* [[Phenytoin]] | |||
* [[Pioglitazone]] | |||
* [[Rifabutin]] | |||
* [[Rifampin]] | |||
* [[St. John's wort]] | |||
}}</div> | |||
Latest revision as of 22:47, 10 January 2020
Substrates of Cytochrome P-450 Isozymes
====CYP1A2 CYP2B6
CYP2C8
CYP2C9
CYP2C19
CYP2D6
CYP2E1
CYP3A
Return to Top====
- Amitriptyline
- Caffeine
- Clomipramine
- Clozapine
- Cyclobenzaprine
- Estradiol
- Fluvoxamine
- Haloperidol
- Mexiletine
- Naproxen
- Olanzapine
- Ondansetron
- Phenacetin
- Propranolol
- Riluzole
- Ropivacaine
- Tacrine
- Theophylline
- Tizanidine
- Verapamil
- R-warfarin
- Zileuton
- Zolmitriptan
CYP2B6 Return to Top
CYP2C8 Return to Top
CYP2C9 Return to Top
- Amitriptyline
- Celecoxib
- Diclofenac
- Fluoxetine
- Fluvastatin
- Glipizide
- Glyburide
- Ibuprofen
- Irbesartan
- Lornoxicam
- Losartan
- Meloxicam
- Nateglinide
- Omeprazole
- Phenytoin
- Piroxicam
- Rosiglitazone
- Rosuvastatin
- S-warfarin
- Tamoxifen
- Tolbutamide
- Torsemide
CYP2C19 Return to Top
- Carisoprodol
- Chloramphenicol
- Citalopram
- Clomipramine
- Cyclophosphamide
- Esomeprazole
- Hexobarbital
- Indomethacin
- Lansoprazole
- Moclobemide
- Nelfinavir
- Nilutamide
- Omeprazole
- Pantoprazole
- Phenobarbital
- Phenytoin
- Primidone
- Progesterone
- Proguanil
- Propranolol
- Rabeprazole
- Teniposide
- Voriconazole
CYP2D6 Return to Top
- Alprenolol
- Amitriptyline
- Amphetamine
- Aripiprazole
- Atomoxetine
- Carvedilol
- Chlorpheniramine
- Chlorpromazine
- Clomipramine
- Codeine
- Debrisoquine
- Desipramine
- Dexfenfluramine
- Dextromethorphan
- Duloxetine
- Encainide
- Flecainide
- Fluoxetine
- Fluvoxamine
- Haloperidol
- Imipramine
- Lidocaine
- Metoclopramide
- Paroxetine
- Perphenazine
- Propafenone
- S-metoprolol
- Thioridazine
- Timolol
CYP2E1 Return to Top
CYP3A Return to Top
- Alfentanil
- Alprazolam
- Amlodipine
- Aprepitant
- Aripiprazole
- Artemisinin
- Astemizole
- Atazanavir
- Atorvastatin
- Boceprevir
- Buspirone
- Cafergot
- Chlorpheniramine
- Cilostazol
- Clarithromycin
- Cocaine
- Cyclosporine
- Dapsone
- Darunavir
- Dexamethasone
- Dextromethorphan
- Diltiazem
- Docetaxel
- Domperidone
- Eplerenone
- Erythromycin
- Estradiol
- Etravirine
- Felodipine
- Fentanyl
- Finasteride
- Fosamprenavir
- Haloperidol
- Hydrocortisone
- Imatinib
- Indinavir
- Irinotecan
- Lidocaine
- Lovastatin
- Midazolam
- Nateglinide
- Nelfinavir
- Nifedipine
- Nisoldipine
- Nitrendipine
- Ondansetron
- Pimozide
- Progesterone
- Quetiapine
- Quinidine
- Quinine
- Risperidone
- Ritonavir
- Salmeterol
- Saquinavir
- Sildenafil
- Simvastatin
- Sirolimus
- Tacrolimus
- Tadalafil
- Taxol
- Telaprevir
- Telithromycin
- Terfenadine
- Testosterone
- Tipranavir
- Trazodone
- Triazolam
- Troleandomycin
- Vardenafil
- Verapamil
- Vincristine
- Zaleplon
- Ziprasidone
- Zolpidem
Inhibitors of Cytochrome P-450 Isozymes
====CYP1A2 CYP2B6
CYP2C8
CYP2C9
CYP2C19
CYP2D6
CYP2E1
CYP3A
Return to Top====
CYP2B6 Return to Top
CYP2C8 Return to Top
CYP2C9 Return to Top
- Amiodarone
- Fenofibrate
- Fluconazole
- Fluvastatin
- Fluvoxamine
- Isoniazid
- Probenecid
- Sertraline
- Sulfamethoxazole
- Teniposide
- Voriconazole
- Zafirlukast
CYP2C19 Return to Top
- Cimetidine
- Esomeprazole
- Felbamate
- Fluoxetine
- Fluvoxamine
- Indomethacin
- Ketoconazole
- Lansoprazole
- Modafinil
- Omeprazole
- Oxcarbazepine
- Pantoprazole
- Probenecid
- Rabeprazole
- Ticlopidine
- Topiramate
CYP2D6 Return to Top
- Amiodarone
- Bupropion
- Celecoxib
- Chlorpheniramine
- Chlorpromazine
- Cimetidine
- Citalopram
- Clemastine
- Clomipramine
- Cocaine
- Diphenhydramine
- Doxepin
- Doxorubicin
- Duloxetine
- Escitalopram
- Fluoxetine
- Halofantrine
- Hydroxyzine
- Metoclopramide
- Mibefradil
- Midodrine
- Moclobemide
- Paroxetine
- Perphenazine
- Quinidine
- Ranitidine
- Ritonavir
- Sertraline
- Terbinafine
- Ticlopidine
CYP2E1 Return to Top
CYP3A Return to Top
- Amiodarone
- Aprepitant
- Cimetidine
- Clarithromycin
- Cobicistat
- Delavirdine
- Diltiazem
- Elvitegravir
- Erythromycin
- Fluconazole
- Fluvoxamine
- Gestodene
- Imatinib
- Indinavir
- Itraconazole
- Ketoconazole
- Mibefradil
- Mifepristone
- Nefazodone
- Nelfinavir
- Norfloxacin
- Norfluoxetine
- Posaconazole
- Ritonavir
- Saquinavir
- Telithromycin
- Verapamil
- Voriconazole
Inducers of Cytochrome P-450 Isozymes
====CYP1A2 CYP2B6
CYP2C8
CYP2C9
CYP2C19
CYP2D6
CYP2E1
CYP3A
Return to Top====