IL17RA: Difference between revisions

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{{Infobox_gene}}
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'''Interleukin 17 receptor A''', also known as '''IL17RA''' and '''CDw217''' ([[cluster of differentiation]] w217), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IL17RA interleukin 17 receptor A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23765| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Interleukin 17 receptor A
| HGNCid = 5985
| Symbol = IL17RA
| AltSymbols =; CDw217; IL-17RA; IL17R; MGC10262; hIL-17R
| OMIM = 605461
| ECnumber = 
| Homologene = 7378
| MGIid = 107399
| GeneAtlas_image1 = PBB_GE_IL17RA_205707_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0030368 |text = interleukin-17 receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23765
    | Hs_Ensembl = ENSG00000177663
    | Hs_RefseqProtein = NP_055154
    | Hs_RefseqmRNA = NM_014339
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 15945858
    | Hs_GenLoc_end = 15971387
    | Hs_Uniprot = Q96F46
    | Mm_EntrezGene = 16172
    | Mm_Ensembl = ENSMUSG00000002897
    | Mm_RefseqmRNA = NM_008359
    | Mm_RefseqProtein = NP_032385
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 120428866
    | Mm_GenLoc_end = 120449348
    | Mm_Uniprot = Q60943
  }}
}}
'''Interleukin 17 receptor A''', also known as '''IL17RA''' and '''CDw217''' ([[cluster of differentiation]] w217), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IL17RA interleukin 17 receptor A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23765| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.<ref name="entrez">{{cite web | title = Entrez Gene: IL17RA interleukin 17 receptor A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23765| accessdate = }}</ref>
| summary_text = Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Yao Z, Spriggs MK, Derry JM, ''et al.'' |title=Molecular characterization of the human interleukin (IL)-17 receptor. |journal=Cytokine |volume=9 |issue= 11 |pages= 794-800 |year= 1998 |pmid= 9367539 |doi=  }}
*{{cite journal   |vauthors=Yao Z, Spriggs MK, Derry JM, etal |title=Molecular characterization of the human interleukin (IL)-17 receptor |journal=Cytokine |volume=9 |issue= 11 |pages= 794–800 |year= 1998 |pmid= 9367539 |doi=10.1006/cyto.1997.0240 }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal   |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal | author=Honorati MC, Meliconi R, Pulsatelli L, ''et al.'' |title=High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients. |journal=Rheumatology (Oxford) |volume=40 |issue= 5 |pages= 522-7 |year= 2001 |pmid= 11371660 |doi=  }}
*{{cite journal   |vauthors=Honorati MC, Meliconi R, Pulsatelli L, etal |title=High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients |journal=Rheumatology (Oxford) |volume=40 |issue= 5 |pages= 522–7 |year= 2001 |pmid= 11371660 |doi=10.1093/rheumatology/40.5.522 }}
*{{cite journal | author=Footz TK, Brinkman-Mills P, Banting GS, ''et al.'' |title=Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere. |journal=Genome Res. |volume=11 |issue= 6 |pages= 1053-70 |year= 2001 |pmid= 11381032 |doi= 10.1101/gr.154901 }}
*{{cite journal   |vauthors=Footz TK, Brinkman-Mills P, Banting GS, etal |title=Analysis of the Cat Eye Syndrome Critical Region in Humans and the Region of Conserved Synteny in Mice: A Search for Candidate Genes at or near the Human Chromosome 22 Pericentromere |journal=Genome Res. |volume=11 |issue= 6 |pages= 1053–70 |year= 2001 |pmid= 11381032 |doi= 10.1101/gr.154901 | pmc=311098 }}
*{{cite journal  | author=Haudenschild D, Moseley T, Rose L, Reddi AH |title=Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer. |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 4309-16 |year= 2002 |pmid= 11706037 |doi= 10.1074/jbc.M109372200 }}
*{{cite journal  |vauthors=Haudenschild D, Moseley T, Rose L, Reddi AH |title=Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 4309–16 |year= 2002 |pmid= 11706037 |doi= 10.1074/jbc.M109372200 }}
*{{cite journal  | author=Kehlen A, Thiele K, Riemann D, Langner J |title=Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis. |journal=Clin. Exp. Immunol. |volume=127 |issue= 3 |pages= 539-46 |year= 2002 |pmid= 11966773 |doi=  }}
*{{cite journal  |vauthors=Kehlen A, Thiele K, Riemann D, Langner J |title=Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis |journal=Clin. Exp. Immunol. |volume=127 |issue= 3 |pages= 539–46 |year= 2002 |pmid= 11966773 |doi=10.1046/j.1365-2249.2002.01782.x  | pmc=1906300 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Steiner GE, Newman ME, Paikl D, ''et al.'' |title=Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate. |journal=Prostate |volume=56 |issue= 3 |pages= 171-82 |year= 2003 |pmid= 12772186 |doi= 10.1002/pros.10238 }}
*{{cite journal   |vauthors=Steiner GE, Newman ME, Paikl D, etal |title=Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate |journal=Prostate |volume=56 |issue= 3 |pages= 171–82 |year= 2003 |pmid= 12772186 |doi= 10.1002/pros.10238 }}
*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal  |vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=McAllister F, Henry A, Kreindler JL, ''et al.'' |title=Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. |journal=J. Immunol. |volume=175 |issue= 1 |pages= 404-12 |year= 2005 |pmid= 15972674 |doi=  }}
*{{cite journal   |vauthors=McAllister F, Henry A, Kreindler JL, etal |title=Role of IL-17A, IL-17F, and the IL-17 Receptor in Regulating Growth-Related Oncogene-α and Granulocyte Colony-Stimulating Factor in Bronchial Epithelium: Implications for Airway Inflammation in Cystic Fibrosis |journal=J. Immunol. |volume=175 |issue= 1 |pages= 404–12 |year= 2005 |pmid= 15972674 |doi= 10.4049/jimmunol.175.1.404| pmc=2849297 }}
*{{cite journal | author=Pongcharoen S, Niumsup P, Sanguansermsri D, ''et al.'' |title=The effect of interleukin-17 on the proliferation and invasion of JEG-3 human choriocarcinoma cells. |journal=Am. J. Reprod. Immunol. |volume=55 |issue= 4 |pages= 291-300 |year= 2006 |pmid= 16533341 |doi= 10.1111/j.1600-0897.2006.00366.x }}
*{{cite journal   |vauthors=Pongcharoen S, Niumsup P, Sanguansermsri D, etal |title=The effect of interleukin-17 on the proliferation and invasion of JEG-3 human choriocarcinoma cells |journal=Am. J. Reprod. Immunol. |volume=55 |issue= 4 |pages= 291–300 |year= 2006 |pmid= 16533341 |doi= 10.1111/j.1600-0897.2006.00366.x }}
*{{cite journal | author=Toy D, Kugler D, Wolfson M, ''et al.'' |title=Cutting edge: interleukin 17 signals through a heteromeric receptor complex. |journal=J. Immunol. |volume=177 |issue= 1 |pages= 36-9 |year= 2006 |pmid= 16785495 |doi=  }}
*{{cite journal   |vauthors=Toy D, Kugler D, Wolfson M, etal |title=Cutting edge: interleukin 17 signals through a heteromeric receptor complex |journal=J. Immunol. |volume=177 |issue= 1 |pages= 36–9 |year= 2006 |pmid= 16785495 |doi=  10.4049/jimmunol.177.1.36}}
*{{cite journal  | author=Wang X, Dong Z, Zhu DD, Guan B |title=Expression profile of immune-associated genes in nasal polyps. |journal=Ann. Otol. Rhinol. Laryngol. |volume=115 |issue= 6 |pages= 450-6 |year= 2006 |pmid= 16805377 |doi=  }}
*{{cite journal  |vauthors=Wang X, Dong Z, Zhu DD, Guan B |title=Expression profile of immune-associated genes in nasal polyps |journal=Ann. Otol. Rhinol. Laryngol. |volume=115 |issue= 6 |pages= 450–6 |year= 2006 |pmid= 16805377 |doi=  }}
*{{cite journal | author=Rong Z, Cheng L, Ren Y, ''et al.'' |title=Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6. |journal=Cell. Signal. |volume=19 |issue= 7 |pages= 1514-20 |year= 2007 |pmid= 17346928 |doi= 10.1016/j.cellsig.2007.01.025 }}
*{{cite journal   |vauthors=Rong Z, Cheng L, Ren Y, etal |title=Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6 |journal=Cell. Signal. |volume=19 |issue= 7 |pages= 1514–20 |year= 2007 |pmid= 17346928 |doi= 10.1016/j.cellsig.2007.01.025 }}
*{{cite journal | author=Maitra A, Shen F, Hanel W, ''et al.'' |title=Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 18 |pages= 7506-11 |year= 2007 |pmid= 17456598 |doi= 10.1073/pnas.0611589104 }}
*{{cite journal   |vauthors=Maitra A, Shen F, Hanel W, etal |title=Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 18 |pages= 7506–11 |year= 2007 |pmid= 17456598 |doi= 10.1073/pnas.0611589104 | pmc=1863505 }}
}}
}}
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{{refend}}
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* {{MeshName|IL17RA+protein,+human}}
* {{MeshName|IL17RA+protein,+human}}


{{membrane-protein-stub}}
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{{Clusters of differentiation}}
{{Clusters of differentiation}}
{{Interleukin receptor modulators}}


[[Category:Cytokine receptors]]
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[[Category:IL17 family cytokine receptors]]
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
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Revision as of 23:47, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene.[1]

Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: IL17RA interleukin 17 receptor A".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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