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'''Enteropeptidase''' or '''enterokinase''' is an [[enzyme]] involved in human [[digestion]].  It is produced by cells in the duodenum wall, and is secreted from duodenum's glands, the [[crypts of Lieberkühn]], whenever ingested food enters the duodenum from the stomach.  Enteropeptidase has the critical job of turning [[trypsinogen]] (a [[zymogen]]) to [[trypsin]], indirectly activating a number of [[pancreas|pancreatic]] digestive enzymes.
'''Enteropeptidase''' or '''enterokinase''' is an [[enzyme]] involved in human [[digestion]].  It is produced by cells in the duodenum wall, and is secreted from duodenum's glands, the [[crypts of Lieberkühn]], whenever ingested food enters the duodenum from the stomach.  Enteropeptidase has the critical job of turning [[trypsinogen]] (a [[zymogen]]) to [[trypsin]], indirectly activating a number of [[pancreas|pancreatic]] digestive enzymes.
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Revision as of 02:16, 9 August 2012

protease, serine, 7 (enterokinase)
Crystal structure of Enteropeptidase with an inhibitor
Identifiers
SymbolPRSS7
Entrez5651
HUGO9490
OMIM606635
RefSeqNM_002772
UniProtP98073
Other data
LocusChr. 21 q21

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Enteropeptidase or enterokinase is an enzyme involved in human digestion. It is produced by cells in the duodenum wall, and is secreted from duodenum's glands, the crypts of Lieberkühn, whenever ingested food enters the duodenum from the stomach. Enteropeptidase has the critical job of turning trypsinogen (a zymogen) to trypsin, indirectly activating a number of pancreatic digestive enzymes.

Enteropeptidase is a serine protease enzyme (EC 3.4.21.9). Enteropeptidase is a part of the Chymotrypsin-clan of serine proteases, and is structurally similar to these proteins.

Reaction

The reaction catalysed by Enteropeptidase:

trypsinogen → trypsin + octapeptide

Enterokinase cleaves after Lysine if the Lys is preceded by four Asp and not followed by a Pro. [1]

Nomenclature

Despite its older name of enterokinase, the enzyme is not a kinase, since it activates its substrate by cleavage and not phosphorylation.

Genetics

Enteropeptidase is encoded by the PRSS7 (serine protease-7 gene) or ENTK gene on the 21st chromosome (21q21).

Isolated cases of enterokinase deficiency have been reported.[2]

References

  1. "Enterokinase, light chain (P8070), Proteases, NEB". Retrieved 2007-10-04.
  2. Holzinger A, Maier EM, Bück C; et al. (2002). "Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency". Am. J. Hum. Genet. 70 (1): 20–5. PMID 11719902.

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de:Enteropeptidase nl:Enterokinase sl:Enteropeptidaza

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