Dihydroorotase: Difference between revisions
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'''Dihydroorotase''' ({{EC number|3.5.2.3}}, ''carbamoylaspartic dehydrase'', ''dihydroorotate hydrolase'') is an enzyme which converts [[carbamoyl aspartic acid]] into [[4,5-dihydroorotic acid]] in the biosynthesis of [[pyrimidines]].<ref>{{cite journal | title = Biosynthesis of pyrimidines | | '''Dihydroorotase''' ({{EC number|3.5.2.3}}, ''carbamoylaspartic dehydrase'', ''dihydroorotate hydrolase'') is an enzyme which converts [[carbamoyl aspartic acid]] into [[4,5-dihydroorotic acid]] in the biosynthesis of [[pyrimidines]].<ref>{{cite journal | title = Biosynthesis of pyrimidines | vauthors = Cooper C, Wilson DW |journal = Fed. Proc. |year = 1954 |volume = 13 |pages = 194–194 |pmid = }}</ref><ref>{{cite journal | vauthors = Lieberman I, Kornberg A | title = Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydroortic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin | journal = The Journal of Biological Chemistry | volume = 207 | issue = 2 | pages = 911–24 | date = April 1954 | pmid = 13163076 | url = http://www.jbc.org/content/207/2/911.full.pdf }}</ref> It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarboymalase. | ||
==See also== | == See also == | ||
* [[Pyrimidine biosynthesis]] | * [[Pyrimidine biosynthesis]] | ||
== References == | == References == | ||
{{reflist}} | {{reflist}} | ||
==External links== | == External links == | ||
* {{MeshName|Dihydroorotase}} | * {{MeshName|Dihydroorotase}} | ||
* {{EC number|3.5.2.3}} | * {{EC number|3.5.2.3}} | ||
Latest revision as of 05:22, 20 March 2018
| carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | |
|---|---|
| File:4by3.jpg Dihydroorotase (fragment) dimer, Human | |
| Identifiers | |
| Symbol | CAD |
| Entrez | 790 |
| HUGO | 1424 |
| OMIM | 114010 |
| RefSeq | NM_004341 |
| UniProt | P27708 |
| Other data | |
| EC number | 3.5.2.3 |
| Locus | Chr. 2 p22-p21 |
Dihydroorotase (EC 3.5.2.3, carbamoylaspartic dehydrase, dihydroorotate hydrolase) is an enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid in the biosynthesis of pyrimidines.[1][2] It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarboymalase.
See also
References
- ↑ Cooper C, Wilson DW (1954). "Biosynthesis of pyrimidines". Fed. Proc. 13: 194–194.
- ↑ Lieberman I, Kornberg A (April 1954). "Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydroortic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin" (PDF). The Journal of Biological Chemistry. 207 (2): 911–24. PMID 13163076.
External links
- Dihydroorotase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 3.5.2.3
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