AICDA

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Activation-induced cytidine deaminase
Identifiers
Symbols AICDA ; ARP2; AID; CDA2; HIGM2
External IDs OMIM: 605257 MGI1342279 HomoloGene7623
RNA expression pattern
PBB GE AICDA 219841 at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 57379
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 11628

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000111732
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000040627

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q9GZX7
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q546Y8

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_020661 (mRNA)
NP_065712 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_009645 (mRNA)
NP_033775 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 12: 8.65 - 8.65 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 6: 122.52 -  122.53 Mb 

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Activation-induced cytidine deaminase, also known as AICDA, is a human gene.[1]


References

  1. "Entrez Gene: AICDA activation-induced cytidine deaminase".

Further reading

  • Wedekind JE, Dance GS, Sowden MP, Smith HC (2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business". Trends Genet. 19 (4): 207–16. PMID 12683974.
  • Bransteitter R, Sneeden JL, Allen S; et al. (2006). "First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies". J. Biol. Chem. 281 (25): 16833–6. doi:10.1074/jbc.R600006200. PMID 16624806.
  • Muto T, Muramatsu M, Taniwaki M; et al. (2001). "Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene". Genomics. 68 (1): 85–8. doi:10.1006/geno.2000.6268. PMID 10950930.
  • Revy P, Muto T, Levy Y; et al. (2000). "Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)". Cell. 102 (5): 565–75. PMID 11007475.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
  • Minegishi Y, Lavoie A, Cunningham-Rundles C; et al. (2001). "Mutations in activation-induced cytidine deaminase in patients with hyper IgM syndrome". Clin. Immunol. 97 (3): 203–10. doi:10.1006/clim.2000.4956. PMID 11112359.
  • Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
  • Noguchi E, Shibasaki M, Inudou M; et al. (2001). "Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels". J. Allergy Clin. Immunol. 108 (3): 382–6. doi:10.1067/mai.2001.117456. PMID 11544457.
  • Martin A, Bardwell PD, Woo CJ; et al. (2002). "Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas". Nature. 415 (6873): 802–6. doi:10.1038/nature714. PMID 11823785.
  • Rada C, Jarvis JM, Milstein C (2002). "AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 7003–8. doi:10.1073/pnas.092160999. PMID 12011459.
  • Petersen-Mahrt SK, Harris RS, Neuberger MS (2002). "AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification". Nature. 418 (6893): 99–103. doi:10.1038/nature00862. PMID 12097915.
  • Dudley DD, Manis JP, Zarrin AA; et al. (2002). "Internal IgH class switch region deletions are position-independent and enhanced by AID expression". Proc. Natl. Acad. Sci. U.S.A. 99 (15): 9984–9. doi:10.1073/pnas.152333499. PMID 12114543.
  • Martin A, Scharff MD (2002). "Somatic hypermutation of the AID transgene in B and non-B cells". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12304–8. doi:10.1073/pnas.192442899. PMID 12202747.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Greeve J, Philipsen A, Krause K; et al. (2003). "Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas". Blood. 101 (9): 3574–80. doi:10.1182/blood-2002-08-2424. PMID 12511417.
  • Oppezzo P, Vuillier F, Vasconcelos Y; et al. (2003). "Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation". Blood. 101 (10): 4029–32. doi:10.1182/blood-2002-10-3175. PMID 12521993.
  • Bransteitter R, Pham P, Scharff MD, Goodman MF (2003). "Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4102–7. doi:10.1073/pnas.0730835100. PMID 12651944.
  • Zhu Y, Nonoyama S, Morio T; et al. (2003). "Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase". J. Med. Dent. Sci. 50 (1): 41–6. PMID 12715918.
  • Sohail A, Klapacz J, Samaranayake M; et al. (2003). "Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations". Nucleic Acids Res. 31 (12): 2990–4. PMID 12799424.

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