Decorin

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Decorin
PDB rendering based on 1xcd.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols DCN ; CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B
External IDs Template:OMIM5 Template:MGI HomoloGene: 22430
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Decorin is a proteoglycan on average 90 - 140 kilodaltons (kD) in size.

It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS).

Desmin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly.[1]

Naming

Decorin's name is a derivative of both the fact that it "decorates" collagen, and that it interacts with the "d" and "e" bands.

Function

Decorin appears to influence fibrillogenesis, and also interacts with fibronectin, thrombospondin, the complement component C1q, epidermal growth factor receptor (EGFR) and transforming growth factor-beta (TGF-beta).

In some publications, decorin has been shown to enhance the bioactivity of TGF-beta 1, in other publications, TGF-beta 1's bioactivity has been shown to be inhibited. Because of this, it is believed the primary function of decorin lies in certain aspects of regulation during the cell cycle.

Infusion of decorin into experimental rodent spinal cord injuries has been shown to suppress scar formation and promote axon growth.

Decorin has been shown to have anti-tumorigenic properties in an experimental murine tumor model and is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for the decorin gene. It is a candidate gene for Marfan syndrome.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: DCN decorin".

Further reading

  • Ständer M, Naumann U, Wick W, Weller M (1999). "Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth". Cell Tissue Res. 296 (2): 221–7. PMID 10382266.
  • Fujisawa R (2002). "[Recent advances in research on bone matrix proteins]". Nippon Rinsho. 60 Suppl 3: 72–8. PMID 11979972.
  • Krumdieck R, Höök M, Rosenberg LC, Volanakis JE (1992). "The proteoglycan decorin binds C1q and inhibits the activity of the C1 complex". J. Immunol. 149 (11): 3695–701. PMID 1431141.
  • Winnemöller M, Schön P, Vischer P, Kresse H (1993). "Interactions between thrombospondin and the small proteoglycan decorin: interference with cell attachment". Eur. J. Cell Biol. 59 (1): 47–55. PMID 1468447.
  • Murphy-Ullrich JE, Schultz-Cherry S, Höök M (1992). "Transforming growth factor-beta complexes with thrombospondin". Mol. Biol. Cell. 3 (2): 181–8. PMID 1550960.
  • Pulkkinen L, Alitalo T, Krusius T, Peltonen L (1992). "Expression of decorin in human tissues and cell lines and defined chromosomal assignment of the gene locus (DCN)". Cytogenet. Cell Genet. 60 (2): 107–11. PMID 1611907.
  • McBride OW, Fisher LW, Young MF (1990). "Localization of PGI (biglycan, BGN) and PGII (decorin, DCN, PG-40) genes on human chromosomes Xq13-qter and 12q, respectively". Genomics. 6 (2): 219–25. PMID 1968422.
  • Fleischmajer R, Fisher LW, MacDonald ED; et al. (1991). "Decorin interacts with fibrillar collagen of embryonic and adult human skin". J. Struct. Biol. 106 (1): 82–90. PMID 2059554.
  • Pulkkinen L, Kainulainen K, Krusius T; et al. (1990). "Deficient expression of the gene coding for decorin in a lethal form of Marfan syndrome". J. Biol. Chem. 265 (29): 17780–5. PMID 2211661.
  • Yamaguchi Y, Mann DM, Ruoslahti E (1990). "Negative regulation of transforming growth factor-beta by the proteoglycan decorin". Nature. 346 (6281): 281–4. doi:10.1038/346281a0. PMID 2374594.
  • Greve H, Blumberg P, Schmidt G; et al. (1990). "Influence of collagen lattice on the metabolism of small proteoglycan II by cultured fibroblasts". Biochem. J. 269 (1): 149–55. PMID 2375748.
  • Roughley PJ, White RJ (1990). "Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II". Biochem. J. 262 (3): 823–7. PMID 2590169.
  • Fisher LW, Termine JD, Young MF (1989). "Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species". J. Biol. Chem. 264 (8): 4571–6. PMID 2647739.
  • Yamaguchi Y, Ruoslahti E (1988). "Expression of human proteoglycan in Chinese hamster ovary cells inhibits cell proliferation". Nature. 336 (6196): 244–6. doi:10.1038/336244a0. PMID 3194009.
  • Krusius T, Ruoslahti E (1986). "Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA". Proc. Natl. Acad. Sci. U.S.A. 83 (20): 7683–7. PMID 3484330.
  • Fisher LW, Hawkins GR, Tuross N, Termine JD (1987). "Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone". J. Biol. Chem. 262 (20): 9702–8. PMID 3597437.
  • Lysiak JJ, Hunt J, Pringle GA, Lala PK (1995). "Localization of transforming growth factor beta and its natural inhibitor decorin in the human placenta and decidua throughout gestation". Placenta. 16 (3): 221–31. PMID 7638106.
  • Takeuchi Y, Kodama Y, Matsumoto T (1995). "Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivity". J. Biol. Chem. 269 (51): 32634–8. PMID 7798269.
  • Scholzen T, Solursh M, Suzuki S; et al. (1994). "The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation". J. Biol. Chem. 269 (45): 28270–81. PMID 7961765.
  • Danielson KG, Fazzio A, Cohen I; et al. (1993). "The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23". Genomics. 15 (1): 146–60. doi:10.1006/geno.1993.1022. PMID 8432526.


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