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{{Infobox_gene}}
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'''Cytochrome P450 26B1''' is a [[protein]] that in humans is encoded by the ''CYP26B1'' [[gene]].<ref name="pmid10545224">{{cite journal | author = Nelson DR | title = A second CYP26 P450 in humans and zebrafish: CYP26B1 | journal = Arch Biochem Biophys | volume = 371 | issue = 2 | pages = 345–7 |date=Dec 1999 | pmid = 10545224 | pmc =  | doi = 10.1006/abbi.1999.1438 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56603| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Cytochrome P450, family 26, subfamily B, polypeptide 1
| HGNCid = 20581
| Symbol = CYP26B1
| AltSymbols =; CYP26A2; DKFZp686G0638; MGC129613; P450RAI-2
| OMIM = 605207
| ECnumber =
| Homologene = 23179
| MGIid = 2176159
  | GeneAtlas_image1 = PBB_GE_CYP26B1_219825_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}}{{GNF_GO|id=GO:0005506 |text = iron ion binding}}{{GNF_GO|id=GO:0020037 |text = heme binding}}{{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0009954 |text = proximal/distal pattern formation}} {{GNF_GO|id=GO:0030326 |text = embryonic limb morphogenesis}} {{GNF_GO|id=GO:0048384 |text = retinoic acid receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 56603
    | Hs_Ensembl = ENSG00000003137
    | Hs_RefseqProtein = NP_063938
    | Hs_RefseqmRNA = NM_019885
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 72209875
    | Hs_GenLoc_end = 72228471
    | Hs_Uniprot = Q9NR63
    | Mm_EntrezGene = 232174
    | Mm_Ensembl = ENSMUSG00000063415
    | Mm_RefseqmRNA = NM_175475
    | Mm_RefseqProtein = NP_780684
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 84537602
    | Mm_GenLoc_end = 84559566
    | Mm_Uniprot = 
  }}
}}
 
{{CMG}}
 
 
 
'''Cytochrome P450, family 26, subfamily B, polypeptide 1''', also known as '''CYP26B1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56603| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene is involved in the specific inactivation of all-trans-retinoic acid to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid.<ref name="entrez">{{cite web | title = Entrez Gene: CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56603| accessdate = }}</ref>
| summary_text = This gene encodes a member of the [[cytochrome P450]] [[Protein superfamily|superfamily]] of [[enzymes]]. The cytochrome P450 proteins are [[monooxygenase|monooxygenases]] that catalyze many reactions involved in [[drug metabolism]] and the synthesis of [[cholesterol]], [[steroids]] and other [[lipids]]. The enzyme encoded by this gene is involved in the specific inactivation of [[Tretinoin|all-trans-retinoic acid]] to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid.<ref name="entrez" />
}}
}}
CYP26B1 has been shown to be over-expressed in [[colorectal cancer]] cells compared to normal [[Large intestine|colonic]] [[Intestinal epithelium|epithelium]]. CYP26B1 expression was also independently prognostic in patients with colorectal cancer and strong expression was associated with a poorer outcome.<ref>{{cite journal|last=Brown|first=Gordon|author2=Beatriz Cash |author3=Daniela Blihoghe |author4=Petronella Johansson |author5=Ayham Alnabulsi |author6=Graeme Murray |title=The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer|journal=PLOS ONE|date=2014-03-07|doi=10.1371/journal.pone.0090776|url=http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090776#ack |pmid=24608339 |pmc=3946526 |volume=9 |pages=e90776}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CYP26B1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Rat E, Billaut-Laden I, Allorge D, ''et al.'' |title=Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida. |journal=Birth Defects Res. Part A Clin. Mol. Teratol. |volume=76 |issue= 6 |pages= 491-8 |year= 2006 |pmid= 16933217 |doi= 10.1002/bdra.20275 }}
*{{cite journal  | vauthors=Rat E, Billaut-Laden I, Allorge D |title=Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida |journal=Birth Defects Res. Part a Clin. Mol. Teratol. |volume=76 |issue= 6 |pages= 491–8 |year= 2006 |pmid= 16933217 |doi= 10.1002/bdra.20275 |display-authors=etal}}
*{{cite journal  | author=Bowles J, Knight D, Smith C, ''et al.'' |title=Retinoid signaling determines germ cell fate in mice. |journal=Science |volume=312 |issue= 5773 |pages= 596-600 |year= 2006 |pmid= 16574820 |doi= 10.1126/science.1125691 }}
*{{cite journal  | vauthors=Bowles J, Knight D, Smith C |title=Retinoid signaling determines germ cell fate in mice |journal=Science |volume=312 |issue= 5773 |pages= 596–600 |year= 2006 |pmid= 16574820 |doi= 10.1126/science.1125691 |display-authors=etal}}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Trofimova-Griffin ME, Juchau MR |title=Developmental expression of cytochrome CYP26B1 (P450RAI-2) in human cephalic tissues. |journal=Brain Res. Dev. Brain Res. |volume=136 |issue= 2 |pages= 175-8 |year= 2002 |pmid= 12101034 |doi=  }}
*{{cite journal  | vauthors=Trofimova-Griffin ME, Juchau MR |title=Developmental expression of cytochrome CYP26B1 (P450RAI-2) in human cephalic tissues |journal=Brain Res. Dev. Brain Res. |volume=136 |issue= 2 |pages= 175–8 |year= 2002 |pmid= 12101034 |doi=10.1016/S0165-3806(02)00305-X }}
*{{cite journal  | author=Abu-Abed S, MacLean G, Fraulob V, ''et al.'' |title=Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis. |journal=Mech. Dev. |volume=110 |issue= 1-2 |pages= 173-7 |year= 2002 |pmid= 11744378 |doi=  }}
*{{cite journal  | vauthors=Abu-Abed S, MacLean G, Fraulob V |title=Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis |journal=Mech. Dev. |volume=110 |issue= 1–2 |pages= 173–7 |year= 2002 |pmid= 11744378 |doi=10.1016/S0925-4773(01)00572-X |display-authors=etal}}
*{{cite journal  | author=White JA, Ramshaw H, Taimi M, ''et al.'' |title=Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 12 |pages= 6403-8 |year= 2000 |pmid= 10823918 |doi= 10.1073/pnas.120161397 }}
*{{cite journal  | vauthors=White JA, Ramshaw H, Taimi M |title=Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 12 |pages= 6403–8 |year= 2000 |pmid= 10823918 |doi= 10.1073/pnas.120161397  | pmc=18615 |display-authors=etal}}
*{{cite journal | author=Nelson DR |title=A second CYP26 P450 in humans and zebrafish: CYP26B1. |journal=Arch. Biochem. Biophys. |volume=371 |issue= 2 |pages= 345-7 |year= 1999 |pmid= 10545224 |doi= 10.1006/abbi.1999.1438 }}
}}
}}
{{refend}}
{{refend}}


{{WH}}
 
{{WS}}
{{Cytochrome P450}}
 
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Revision as of 10:14, 30 August 2017

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Cytochrome P450 26B1 is a protein that in humans is encoded by the CYP26B1 gene.[1][2]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene is involved in the specific inactivation of all-trans-retinoic acid to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid.[2]

CYP26B1 has been shown to be over-expressed in colorectal cancer cells compared to normal colonic epithelium. CYP26B1 expression was also independently prognostic in patients with colorectal cancer and strong expression was associated with a poorer outcome.[3]

References

  1. ↑ Nelson DR (Dec 1999). "A second CYP26 P450 in humans and zebrafish: CYP26B1". Arch Biochem Biophys. 371 (2): 345–7. doi:10.1006/abbi.1999.1438. PMID 10545224.
  2. ↑ 2.0 2.1 "Entrez Gene: CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1".
  3. ↑ Brown, Gordon; Beatriz Cash; Daniela Blihoghe; Petronella Johansson; Ayham Alnabulsi; Graeme Murray (2014-03-07). "The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer". PLOS ONE. 9: e90776. doi:10.1371/journal.pone.0090776. PMC 3946526. PMID 24608339.

External links

Further reading




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