PTGIS

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prostaglandin I2 (prostacyclin) synthase
Identifiers
SymbolPTGIS
Alt. symbolsCYP8A1
Entrez5740
HUGO9603
OMIM601699
RefSeqNM_000961
UniProtQ16647
Other data
EC number5.3.99.4
LocusChr. 20 q13

WikiDoc Resources for PTGIS

Articles

Most recent articles on PTGIS

Most cited articles on PTGIS

Review articles on PTGIS

Articles on PTGIS in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on PTGIS

Images of PTGIS

Photos of PTGIS

Podcasts & MP3s on PTGIS

Videos on PTGIS

Evidence Based Medicine

Cochrane Collaboration on PTGIS

Bandolier on PTGIS

TRIP on PTGIS

Clinical Trials

Ongoing Trials on PTGIS at Clinical Trials.gov

Trial results on PTGIS

Clinical Trials on PTGIS at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on PTGIS

NICE Guidance on PTGIS

NHS PRODIGY Guidance

FDA on PTGIS

CDC on PTGIS

Books

Books on PTGIS

News

PTGIS in the news

Be alerted to news on PTGIS

News trends on PTGIS

Commentary

Blogs on PTGIS

Definitions

Definitions of PTGIS

Patient Resources / Community

Patient resources on PTGIS

Discussion groups on PTGIS

Patient Handouts on PTGIS

Directions to Hospitals Treating PTGIS

Risk calculators and risk factors for PTGIS

Healthcare Provider Resources

Symptoms of PTGIS

Causes & Risk Factors for PTGIS

Diagnostic studies for PTGIS

Treatment of PTGIS

Continuing Medical Education (CME)

CME Programs on PTGIS

International

PTGIS en Espanol

PTGIS en Francais

Business

PTGIS in the Marketplace

Patents on PTGIS

Experimental / Informatics

List of terms related to PTGIS


Prostaglandin I2 (prostacyclin) synthase (PTGIS) (also known as CYP8A1) is a protein which in humans is encoded by the PTGIS gene.[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostaglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.[2]

See also

References

  1. Yokoyama C, Yabuki T, Inoue H, Tone Y, Hara S, Hatae T, Nagata M, Takahashi EI, Tanabe T (1996). "Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity". Genomics. 36 (2): 296–304. doi:10.1006/geno.1996.0465. PMID 8812456. Unknown parameter |month= ignored (help)
  2. "Entrez Gene: PTGIS".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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