CYP2C8

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cytochrome P450, family 2, subfamily C, polypeptide 8
Identifiers
Symbol	CYP2C8
Entrez	1558
HUGO	2622
OMIM	601129
RefSeq	NM_000770
UniProt	P10632
Other data
Locus	Chr. 10 q24.1

Cytochrome P450 2C8 (abbreviated CYP2C8), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.

CYP2C8 Ligands

Selected inducers, inhibitors and substrates of CYP2C81
Type	Agent
inducers	rifampicin
inhibitors	gemfibrozil, glitazones (rosiglitazone, pioglitazone, etc), montelukast, quercetin, trimethoprim
substrates	cerivastatin, paclitaxel, repaglinide, torasemide
Notes: Where classes of agents are listed, there may be exceptions within the class.

See also

• Cytochrome P450 oxidase

v • d • e Cytochromes, oxygenases: cytochrome P450 (EC 1.14)
CYP1	A1, A2, B1
CYP2	A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1
CYP3	A4, A5, A7, A43
CYP4	A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1
CYP5-20	CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1)
CYP21-51	CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1)

rosiglitazone is a CYP2C8 substrate

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .