Steroid 11-beta-hydroxylase

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cytochrome P450, family 11, subfamily B, polypeptide 1
Identifiers
SymbolCYP11B1
Alt. symbolsCYP11B
Entrez1584
HUGO2591
OMIM610613
RefSeqNM_001026213
UniProtP15538
Other data
EC number1.14.15.4

Steroid 11β-hydroxylase is a steroid hydroxylase found in the zona fasciculata.

Function

It generates cortisol from 11-deoxycortisol and corticosterone from 11-deoxycorticosterone. Note the extra "–OH" added at the 11 position (near the center, on ring "C"):

Location in pathway

Clinical significance

A mutation is associated with congenital adrenal hyperplasia due to 11β-hydroxylase deficiency.

Additional images

Steroidogenesis, showing steroid 11-beta-hydroxylase vertically at right.

External links


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