CYP46A1

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External IDsGeneCards: [1]
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SpeciesHumanMouse
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Cholesterol 24-hydroxylase is an enzyme that in humans is encoded by the CYP46A1 gene.[1][2]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood–brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.[2]

References

  1. Lund EG, Guileyardo JM, Russell DW (Jul 1999). "cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain". Proc Natl Acad Sci U S A. 96 (13): 7238–43. doi:10.1073/pnas.96.13.7238. PMC 22064. PMID 10377398.
  2. 2.0 2.1 "Entrez Gene: CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1".

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Further reading




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