Anomalous origins of coronary arteries
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
The coronary arteries are usually perpendicular to the aortic wall and they are radially arranged relative to the center of the aorta. The ostia may be rounding, oval, or elliptical, and the position of the ostium does not appear to affect the flow through it.
Anomalous origins of coronary arteries can be classified as Benign Coronary Anomalies and Potentially More Serious Coronary Artery Anomalies or Coronary Arteries Anomalies without Structural Heart Disease and Coronary Arteries Anomalies with Structural Heart Disease.
Benign Coronary Anomalies
- Separate origin of left anterior descending artery and left circumflex from the left sinus Valsalva
- Absent left circumflex (with maximally dominant right coronary artery)
- Origin of left circumflex artery from right coronary artery or right sinus of Valsalva
- Ectopic origin of right coronary artery or left main trunk from posterior sinus of Valsalva
- Ectopic coronary origin from the ascending aorta
- Intercoronary communication
- Small coronary artery fistula
Potentially More Serious Coronary Artery Anomalies
- Ectopic coronary origin from the pulmonary artery
- Left main trunk from pulmonary artery: Bland-White-Garland syndrome
- Left anterior descending artery from pulmonary artery
- Right coronary artery from pulmonary artery
- All coronary arteries from pulmonary artery
- Ectopic origin of the left coronary artery from the right sinus of Valsalva
- Left main trunk from right sinus of Valsalva
- Left anterior descending artery from right sinus of Valsalva
- Right coronary artery from left sinus of Valsalva
Coronary Arteries Anomalies without Structural Heart Disease
Normal Variations
These anomalies have no any clinical consequences. Separate origin of the conus branch of the right coronary artery is common. The similar anomaly on the left side is ”separate origins of the left anterior descending and left circumflex coronary arteries” occurs in about 1% of people and is more frequent with bicuspid aortic valves. [1] [2]
Images shown below are courtesy of Professor Peter Anderson DVM PhD and published with permission. © PEIR, University of Alabama at Birmingham, Department of Pathology
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Gross natural color high origin of coronary well shown. The heart is enlarged.
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Gross fixed tissue horizontal section of ventricle with intramural right coronary artery also lateral wall scar case of aortic valve prosthesis for aortic stenosis two years problem was arrhythmias
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Anomalous Origin Coronary Artery: Gross natural color close-up view of right coronary artery cusp with two ostia
Abnormal Origin of Right or Left Coronary Artery from Inappropriate Sinus
Anomalous Origin of Left Coronary Arterial Branches from Right Sinus of Valsalva
Images shown below are courtesy of Professor Peter Anderson DVM PhD and published with permission. © PEIR, University of Alabama at Birmingham, Department of Pathology
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Gross aortic valve origin of left coronary artery from right sinus of Valsalva sudden unexpected death
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Gross left coronary artery originates from right sinus of Valsalva sudden unexpected death
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Anomalous Origin Coronary Artery: Gross left atrium and mitral valve normal
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Gross view of aorta from above with probes in coronary artery to illustrate origin of left coronary from right sinus and to a degree at least the relation of the main left coronary with the aorta and pulmonary artery
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Gross natural color close-up of aortic valve opened with probe in origin of left coronary artery which is in right cusp
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Tricuspid valve normal: Gross natural color (a good view) 18 year old African-American male died due to anomalous origin left coronary artery from right cusp
Anomalous Origin of Right Coronary Arterial Branches from the Left Sinus of Valsalva
Single Coronary Artery
- From right coronary sinus
- Right coronary artery continues as left circumflex artery and Left anterior descending artery.
- Right coronary artery gives off left main coronary artery
- Right coronary artery gives off left anterior descending artery and left circumflex artery
- From left coronary sinus
- Left main coronary artery gives off left anterior descending artery, left circumflex artery, and right coronary artery
- Left circumflex artery continues as right coronary artery
- Left circumflex artery gives off right coronary artery
- Left anterior descending artery gives off right coronary artery
Images shown below are courtesy of Professor Peter Anderson DVM PhD and published with permission. © PEIR, University of Alabama at Birmingham, Department of Pathology
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Gross shows common origin of right and left coronary arteries from right coronary cusp
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Gross natural color opened right coronary sinus showing single origin of both coronaries
Rare Coronary Anomalies
Coronary Atresia
Total absence of the epicardial (extramural) coronary arteries is rare and occurs most often with pulmonary atresia and aortic atresia.
In these congenital anomalies, pressure in the small but hypertrophied right or left ventricle is similar or higher than aortic pressure, and enlarged sinusoids carry blood from the ventricle to be distributed in the distal coronary arteries. [3] [4]
Stenosis or Atresia of a Coronary Ostium
- Stenosis or atresia of the ostium or first few millimeters of the left main coronary artery is one of the rarest of the congenital coronary artery anomalies.
- The more distal branches are normal and develop multiple collaterals from the right coronary artery.
- According to published literature, presentation range is 3 months to 60 years of age. Usual presentation with;
All Coronary Arteries from Pulmonary Artery
- Both right and left coronary arteries, or a single coronary artery, may come from the pulmonary trunk.
- These children do not survive infancy without surgical intervention unless there is a cardiac lesion causing pulmonary hypertension. [5]
Left Anterior Descending Coronary Artery from the Pulmonary Artery
Images shown below are courtesy of Professor Peter Anderson DVM PhD and published with permission. © PEIR, University of Alabama at Birmingham, Department of Pathology
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Endocardial Fibroelastosis: Gross fair example LV endocardial thickening associated with anomalous origin of left coronary artery from pulmonary artery
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Left Coronary Artery Anomalous Origin from Pulmonary artery: Angiogram postmortem after switch of left coronary to aorta
Left Circumflex Coronary Artery from the Pulmonary Artery or Branches
Images shown below are courtesy of Professor Peter Anderson DVM PhD and published with permission. © PEIR, University of Alabama at Birmingham, Department of Pathology
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Coronary Artery Anomalous Origin Left from Pulmonary artery: Gross natural color anterior view of heart. Large marginal type coronary branches over anterior aspect of right ventricle.
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Coronary Artery Anomalous Origin Left from Pulmonary artery: Gross natural color anterior view of heart. Large marginal type coronary branches over anterior aspect of right ventricle.
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Coronary Artery Anomalous Origin Left from Pulmonary artery: Gross natural color anterior view of hear showing large marginal type branches over anterior right ventricle 5 month old infant died after operation switching artery to aorta
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Coronary Artery Anomalous Origin Left from Pulmonary artery: Gross fixed tissue. Horizontal sections of ventricles showing thinning in anterior left ventricle due to scar there are some peculiar spots on the ventricles in this photo that probably are artifacts.
Right Coronary Artery from the Pulmonary Artery
- Rare, only about 10% of left main coronary artery originated from the pulmonary artery. [6] [7] [8] [9] [10] [11]
- Almost always found as an incidental autopsy finding of sudden death, and if diagnosed before death it has been associated with:
- Symptoms of myocardial ischemia
- Syncope
- Cardiomyopathy
References
- ↑ Baroldi G, Scomazzoni G. Coronary circulation in the normal and the pathologic heart. Washington, DC: Office of the Surgeon General, 1967
- ↑ Datta J, White CS, Gilkeson RC, Meyer CA, Kansal S, Jani ML, Arildsen RC, Read K Anomalous Coronary Arteries in Adults: Depiction at Multi–Detector Row CT Angiography. Radiology 2005 235: 812-818.
- ↑ Musiani A, Cernigliaro C, Sansa M, Maselli D, De Gasperis C. Left main coronary artery atresia: literature review and therapeutical considerations. Eur J Cardiothorac Surg. 1997 Mar; 11(3):505-14. PMID 9105816
- ↑ Elian D, Hegesh J, Agranat O, Guetta V, Har-Zahav Y, Rath S, Chouraqui P, Di Segni E. Left main coronary artery atresia: extremely rare coronary anomaly in an asymptomatic adult and an adolescent soccer player. Cardiol Rev. 2003 May-Jun;11(3):160-2. PMID 12705847
- ↑ Ochoa-Ramirez E, Valdez-Garza HE, Reyes-Gonzalez R, et al. Double anomalous coronary origin from the pulmonary artery: Successful surgical correction in an infant. Tex Heart Inst J 2005;32:348-50.
- ↑ Coe JY, Radley-Smith R, Yacoub M. Clinical and hemodynamic significance of anomalous origin of the right coronary artery from the pulmonary artery. Thorac Cardiovasc Surg 1982;30:84-7.
- ↑ Fontana RS, Edwards JE. Congenital Cardiac Disease: A Review of 357 Cases Studied Pathologically. Philadelphia: WB Saunders, 1962.
- ↑ Ogden JA. Congenital anomalies of the coronary arteries. Am J Cardiol 1970;25:474-79.
- ↑ Neufeld HN, Schneeweiss A. Coronary Artery Disease in Infants and Children. Philadelphia: Lea & Febiger, 1983.
- ↑ Roberts WC. Major anomalies of coronary arterial origin seen in adulthood. Am Heart J 1986; 111: 941-63.
- ↑ Yao CT, Wang JN, Yeh CN, et al. Isolated anomalous origin of right coronary artery from the main pulmonary artery. J Card Surg 2005;20:487-89.
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