GABRA3

Gamma-aminobutyric acid (GABA) A receptor, alpha 3
Identifiers
Symbols	GABRA3 ; MGC33793
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20218
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Gamma-aminobutyric acid (GABA) A receptor, alpha 3, also known as GABRA3, is a human gene.

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified

See also

• GABAA receptor

Further reading

• Buckle VJ, Fujita N, Ryder-Cook AS; et al. (1990). "Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease". Neuron. 3 (5): 647–54. PMID 2561974.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bell MV, Bloomfield J, McKinley M; et al. (1990). "Physical linkage of a GABAA receptor subunit gene to the DXS374 locus in human Xq28". Am. J. Hum. Genet. 45 (6): 883–8. PMID 2574000.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tögel M, Mossier B, Fuchs K, Sieghart W (1994). "gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties". J. Biol. Chem. 269 (17): 12993–8. PMID 8175718.CS1 maint: Multiple names: authors list (link)
• Hadingham KL, Wingrove P, Le Bourdelles B; et al. (1993). "Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors". Mol. Pharmacol. 43 (6): 970–5. PMID 8391122.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Belelli D, Lambert JJ, Peters JA; et al. (1997). "The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid". Proc. Natl. Acad. Sci. U.S.A. 94 (20): 11031–6. PMID 9380754.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang RQ, Dillon GH (1998). "Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin". J. Pharmacol. Exp. Ther. 286 (1): 243–55. PMID 9655866.
• Amir R, Dahle EJ, Toriolo D, Zoghbi HY (2000). "Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq". Am. J. Med. Genet. 90 (1): 69–71. PMID 10602120.CS1 maint: Multiple names: authors list (link)
• Bedford FK, Kittler JT, Muller E; et al. (2001). "GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1". Nat. Neurosci. 4 (9): 908–16. doi:10.1038/nn0901-908. PMID 11528422.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chou KC (2004). "Modelling extracellular domains of GABA-A receptors: subtypes 1, 2, 3, and 5". Biochem. Biophys. Res. Commun. 316 (3): 636–42. doi:10.1016/j.bbrc.2004.02.098. PMID 15033447.
• Henkel V, Baghai TC, Eser D; et al. (2004). "The gamma amino butyric acid (GABA) receptor alpha-3 subunit gene polymorphism in unipolar depressive disorder: a genetic association study". Am. J. Med. Genet. B Neuropsychiatr. Genet. 126 (1): 82–7. doi:10.1002/ajmg.b.20137. PMID 15048654.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• GABRA3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.