Lymphomatoid granulomatosis pathophysiology: Difference between revisions
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*The exact pathogenesis of [disease name] is not completely understood. | *The exact pathogenesis of [disease name] is not completely understood. | ||
OR | OR | ||
*It is understood that | *It is understood that Lymphomatoid granulomatosis is the result of infection of T cells by EBV.It is described by the presence of an angiocentric and angiodestructive accumulation of differing numbers of T cells with varying numbers of atypical clonal EBV-positive B cells in a polymorphous inflammatory background. | ||
==Genetics== | ==Genetics== | ||
==Associated Conditions== | ==Associated Conditions== | ||
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==Gross Pathology== | ==Gross Pathology== | ||
On gross pathology, | On gross pathology, | ||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
On microscopic histopathological analysis, | On microscopic histopathological analysis, the presence of an angiocentric and angiodestructive accumulation of differing numbers of T cells with varying numbers of atypical clonal EBV-positive B cells in a polymorphous inflammatory background is seen in Lymphomatoid granulomatosis | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 17:11, 20 November 2018
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Lymphomatoid granulomatosis Microchapters |
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Differentiating Lymphomatoid granulomatosis from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Lymphomatoid granulomatosis pathophysiology On the Web |
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American Roentgen Ray Society Images of Lymphomatoid granulomatosis pathophysiology |
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Directions to Hospitals Treating Lymphomatoid granulomatosis |
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Risk calculators and risk factors for Lymphomatoid granulomatosis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Lymphomatoid granulomatosis arises from T cells, which are Lymphoid cells that are normally involved in Immunity.
Pathophysiology
Physiology
The normal physiology of cell mediated immunity can be understood as follows: Historically, the immune system was divided into two branches: humoral immunity, for which the defending function of immunization could be seen in the humor (cell-free bodily fluid or serum) and cellular immunity, for which the defending function of immunization was associated with cells. CD4 cells or helper T cells provide defense against varying pathogenic organisms. Naive T cells, mature T cells that have yet to come upon an antigen, are transformed into activated effector T cells after coming across an antigen-presenting cells (APCs). These APCs, such as macrophages, dendritic cells, and B cells in some cases, pack antigenic peptides onto the MHC of the cell, in turn introducing the peptide to receptors on T cells. The most important of these APCs are highly specialized dendritic cells; conceivably operating solely to ingest and present antigens.[1]
Pathogenesis=
- The exact pathogenesis of [disease name] is not completely understood.
OR
- It is understood that Lymphomatoid granulomatosis is the result of infection of T cells by EBV.It is described by the presence of an angiocentric and angiodestructive accumulation of differing numbers of T cells with varying numbers of atypical clonal EBV-positive B cells in a polymorphous inflammatory background.
Genetics
Associated Conditions
Conditions associated with [disease name] include:
- [Condition 1]
- [Condition 2]
- [Condition 3]
Gross Pathology
On gross pathology,
Microscopic Pathology
On microscopic histopathological analysis, the presence of an angiocentric and angiodestructive accumulation of differing numbers of T cells with varying numbers of atypical clonal EBV-positive B cells in a polymorphous inflammatory background is seen in Lymphomatoid granulomatosis