Lymphomatoid granulomatosis classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kamal Akbar, M.D.[2]

Overview

Lymphomatoid granulomatosis may be classified according to a grading system into low grade and high grade.

Classification

Lymphomatoid granulomatosis may be classified according to a grading system which denotes the amount of EBV positive large B-cell malignant cells that are present. Deciphering the severity of the disease is crucial in determining which treatment options to pursue. The condition is classified into two subtypes:[1]

  • Low grade:
    • Small amount of large atypical cells
    • Few mitotic figures
    • Minute amount of necrosis
    • Some cases resolve on there own
  • High grade:
    • Preponderant population of large atypical cells
    • Profuse necrosis

References

  1. Roschewski M, Wilson WH (2012). "Lymphomatoid granulomatosis". Cancer J. 18 (5): 469–74. doi:10.1097/PPO.0b013e31826c5e19. PMID 23006954.

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