GRIA1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Glutamate receptor 1''' is a [[protein]] that in humans is encoded by the ''GRIA1'' [[gene]].<ref name="pmid1652753">{{cite journal |vauthors=Puckett C, Gomez CM, Korenberg JR, Tung H, Meier TJ, Chen XN, Hood L | title = Molecular cloning and chromosomal localization of one of the human glutamate receptor genes | journal = Proc Natl Acad Sci U S A | volume = 88 | issue = 17 | pages = 7557–61 | date = October 1991 | pmid = 1652753 | pmc = 52340 | doi = 10.1073/pnas.88.17.7557 }}</ref><ref name="pmid1319477">{{cite journal |vauthors=McNamara JO, Eubanks JH, McPherson JD, Wasmuth JJ, Evans GA, Heinemann SF | title = Chromosomal localization of human glutamate receptor genes | journal = J Neurosci | volume = 12 | issue = 7 | pages = 2555–62 | date = July 1992 | pmid = 1319477 | pmc = | doi = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glutamate receptor, ionotropic, AMPA 1
| HGNCid = 4571
| Symbol = GRIA1
| AltSymbols =; GLUH1; GLUR1; GLURA; HBGR1; MGC133252
| OMIM = 138248
| ECnumber = 
| Homologene = 20226
| MGIid = 95808
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004971 |text = alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005234 |text = extracellular-glutamate-gated ion channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015277 |text = kainate selective glutamate receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0014069 |text = postsynaptic density}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007616 |text = long-term memory}} {{GNF_GO|id=GO:0031623 |text = receptor internalization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2890
    | Hs_Ensembl = ENSG00000155511
    | Hs_RefseqProtein = NP_000818
    | Hs_RefseqmRNA = NM_000827
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 152850499
    | Hs_GenLoc_end = 153171354
    | Hs_Uniprot = P42261
    | Mm_EntrezGene = 14799
    | Mm_Ensembl = ENSMUSG00000020524
    | Mm_RefseqmRNA = NM_008165
    | Mm_RefseqProtein = NP_032191
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 57017321
    | Mm_GenLoc_end = 57143990
    | Mm_Uniprot = Q5NBY0
  }}
}}
'''Glutamate receptor, ionotropic, AMPA 1''', also known as '''GRIA1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRIA1 glutamate receptor, ionotropic, AMPA 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2890| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Glutamate receptor]]s are the predominant excitatory [[neurotransmitter]] receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a [[ligand-gated ion channel]]. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate ([[AMPA]]) receptors. Each of the members (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in [[granule cell|granule]] and [[pyramidal cell]]s in the [[hippocampal]] formation.<ref name="entrez">{{cite web | title = Entrez Gene: GRIA1 glutamate receptor, ionotropic, AMPA 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2890| accessdate = }}</ref>
{{PBB_Summary
 
| section_title =
GRIA1 (GluR1) is centrally involved in [[synaptic plasticity]].  Expression of the ''GluR1'' gene is significantly reduced in the human [[frontal lobe|frontal cortex]] with increasing age.<ref name="pmid15190254">{{cite journal |vauthors=Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA |title=Gene regulation and DNA damage in the ageing human brain |journal=Nature |volume=429 |issue=6994 |pages=883–91 |date=June 2004 |pmid=15190254 |doi=10.1038/nature02661 |url=}}</ref>
| summary_text = Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Each of the members (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.<ref name="entrez">{{cite web | title = Entrez Gene: GRIA1 glutamate receptor, ionotropic, AMPA 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2890| accessdate = }}</ref>
 
}}
==Interactions==
GRIA1 has been shown to [[Protein-protein interaction|interact]] with:
* [[DLG1]]<ref name = pmid12933808>{{cite journal |vauthors=Gardoni F, Mauceri D, Fiorentini C, Bellone C, Missale C, Cattabeni F, Di Luca M | title = CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction | journal = J. Biol. Chem. | volume = 278 | issue = 45 | pages = 44745–52 | date = November 2003 | pmid = 12933808 | doi = 10.1074/jbc.M303576200 }}</ref><ref name = pmid9677374>{{cite journal |vauthors=Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW | title = SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit | journal = J. Biol. Chem. | volume = 273 | issue = 31 | pages = 19518–24 | date = July 1998 | pmid = 9677374 | doi =  10.1074/jbc.273.31.19518}}</ref><ref name = pmid11567040>{{cite journal |vauthors=Sans N, Racca C, Petralia RS, Wang YX, McCallum J, Wenthold RJ | title = Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway | journal = J. Neurosci. | volume = 21 | issue = 19 | pages = 7506–16 | date = October 2001 | pmid = 11567040 | doi =  }}</ref>
* [[EPB41L2]],<ref name = pmid11050113>{{cite journal |vauthors=Shen L, Liang F, Walensky LD, Huganir RL | title = Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association | journal = J. Neurosci. | volume = 20 | issue = 21 | pages = 7932–40 | date = November 2000 | pmid = 11050113 | doi =  }}</ref> and
* [[GRID2]].<ref name = pmid12573530>{{cite journal |vauthors=Kohda K, Kamiya Y, Matsuda S, Kato K, Umemori H, Yuzaki M | title = Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors | journal = Brain Res. Mol. Brain Res. | volume = 110 | issue = 1 | pages = 27–37 | date = January 2003 | pmid = 12573530 | doi =  10.1016/s0169-328x(02)00561-2}}</ref>


==See also==
==See also==
Line 57: Line 18:


==References==
==References==
{{reflist|2}}
{{reflist|35em}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin|35em}}
{{PBB_Further_reading
*{{cite journal |vauthors=Sun W, Ferrer-Montiel AV, Schinder AF, McPherson JP, Evans GA, Montal M | title = Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 4 | pages = 1443–7 | year = 1992 | pmid = 1311100 | pmc = 48467 | doi = 10.1073/pnas.89.4.1443 }}
| citations =
*{{cite journal |vauthors=Potier MC, Spillantini MG, Carter NP | title = The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. | journal = DNA Seq. | volume = 2 | issue = 4 | pages = 211–8 | year = 1992 | pmid = 1320959 | doi = 10.3109/10425179209020805 }}
*{{cite journal | author=Sun W, Ferrer-Montiel AV, Schinder AF, ''et al.'' |title=Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1443-7 |year= 1992 |pmid= 1311100 |doi= }}
*{{cite journal |vauthors=Yakel JL, Vissavajjhala P, Derkach VA, Brickey DA, Soderling TR | title = Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 5 | pages = 1376–80 | year = 1995 | pmid = 7877986 | pmc = 42522 | doi = 10.1073/pnas.92.5.1376 }}
*{{cite journal | author=McNamara JO, Eubanks JH, McPherson JD, ''et al.'' |title=Chromosomal localization of human glutamate receptor genes. |journal=J. Neurosci. |volume=12 |issue= 7 |pages= 2555-62 |year= 1992 |pmid= 1319477 |doi= }}
*{{cite journal |vauthors=Eastwood SL, Burnet PW, Beckwith J, Kerwin RW, Harrison PJ | title = AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus. | journal = NeuroReport | volume = 5 | issue = 11 | pages = 1325–8 | year = 1994 | pmid = 7919190 | doi = 10.1097/00001756-199406270-00007 }}
*{{cite journal | author=Potier MC, Spillantini MG, Carter NP |title=The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. |journal=DNA Seq. |volume=2 |issue= 4 |pages= 211-8 |year= 1992 |pmid= 1320959 |doi= }}
*{{cite journal |vauthors=Roche KW, Raymond LA, Blackstone C, Huganir RL | title = Transmembrane topology of the glutamate receptor subunit GluR6. | journal = J. Biol. Chem. | volume = 269 | issue = 16 | pages = 11679–82 | year = 1994 | pmid = 8163463 | doi =  }}
*{{cite journal | author=Puckett C, Gomez CM, Korenberg JR, ''et al.'' |title=Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 17 |pages= 7557-61 |year= 1991 |pmid= 1652753 |doi= }}
*{{cite journal |vauthors=McLaughlin DP, Cheetham ME, Kerwin RW | title = Expression of alternatively-spliced glutamate receptors in human hippocampus. | journal = Eur. J. Pharmacol. | volume = 244 | issue = 1 | pages = 89–92 | year = 1993 | pmid = 8420792 | doi = 10.1016/0922-4106(93)90062-E }}
*{{cite journal | author=Yakel JL, Vissavajjhala P, Derkach VA, ''et al.'' |title=Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 5 |pages= 1376-80 |year= 1995 |pmid= 7877986 |doi=  }}
*{{cite journal |vauthors=Roche KW, O'Brien RJ, Mammen AL, Bernhardt J, Huganir RL | title = Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. | journal = Neuron | volume = 16 | issue = 6 | pages = 1179–88 | year = 1996 | pmid = 8663994 | doi = 10.1016/S0896-6273(00)80144-0 }}
*{{cite journal | author=Eastwood SL, Burnet PW, Beckwith J, ''et al.'' |title=AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus. |journal=Neuroreport |volume=5 |issue= 11 |pages= 1325-8 |year= 1994 |pmid= 7919190 |doi= }}
*{{cite journal |vauthors=Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF | title = Homer: a protein that selectively binds metabotropic glutamate receptors. | journal = Nature | volume = 386 | issue = 6622 | pages = 284–8 | year = 1997 | pmid = 9069287 | doi = 10.1038/386284a0 }}
*{{cite journal | author=Roche KW, Raymond LA, Blackstone C, Huganir RL |title=Transmembrane topology of the glutamate receptor subunit GluR6. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 11679-82 |year= 1994 |pmid= 8163463 |doi= }}
*{{cite journal |vauthors=Barria A, Derkach V, Soderling T | title = Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor. | journal = J. Biol. Chem. | volume = 272 | issue = 52 | pages = 32727–30 | year = 1998 | pmid = 9407043 | doi = 10.1074/jbc.272.52.32727 }}
*{{cite journal | author=McLaughlin DP, Cheetham ME, Kerwin RW |title=Expression of alternatively-spliced glutamate receptors in human hippocampus. |journal=Eur. J. Pharmacol. |volume=244 |issue= 1 |pages= 89-92 |year= 1993 |pmid= 8420792 |doi= }}
*{{cite journal |vauthors=Ripellino JA, Neve RL, Howe JR | title = Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum. | journal = Neuroscience | volume = 82 | issue = 2 | pages = 485–97 | year = 1998 | pmid = 9466455 | doi = 10.1016/S0306-4522(97)00296-0 }}
*{{cite journal | author=Roche KW, O'Brien RJ, Mammen AL, ''et al.'' |title=Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. |journal=Neuron |volume=16 |issue= 6 |pages= 1179-88 |year= 1996 |pmid= 8663994 |doi=  }}
*{{cite journal |vauthors=Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW | title = SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. | journal = J. Biol. Chem. | volume = 273 | issue = 31 | pages = 19518–24 | year = 1998 | pmid = 9677374 | doi = 10.1074/jbc.273.31.19518 }}
*{{cite journal | author=Brakeman PR, Lanahan AA, O'Brien R, ''et al.'' |title=Homer: a protein that selectively binds metabotropic glutamate receptors. |journal=Nature |volume=386 |issue= 6622 |pages= 284-8 |year= 1997 |pmid= 9069287 |doi= 10.1038/386284a0 }}
*{{cite journal |vauthors=Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF | title = Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. | journal = Neuron | volume = 21 | issue = 4 | pages = 707–16 | year = 1998 | pmid = 9808458 | doi = 10.1016/S0896-6273(00)80588-7 }}
*{{cite journal | author=Barria A, Derkach V, Soderling T |title=Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 32727-30 |year= 1998 |pmid= 9407043 |doi= }}
*{{cite journal |vauthors=Montague AA, Greer CA | title = Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb. | journal = J. Comp. Neurol. | volume = 405 | issue = 2 | pages = 233–46 | year = 1999 | pmid = 10023812 | doi = 10.1002/(SICI)1096-9861(19990308)405:2<233::AID-CNE7>3.0.CO;2-A }}
*{{cite journal | author=Ripellino JA, Neve RL, Howe JR |title=Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum. |journal=Neuroscience |volume=82 |issue= 2 |pages= 485-97 |year= 1998 |pmid= 9466455 |doi= }}
*{{cite journal |vauthors=Leuschner WD, Hoch W | title = Subtype-specific assembly of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits is mediated by their n-terminal domains. | journal = J. Biol. Chem. | volume = 274 | issue = 24 | pages = 16907–16 | year = 1999 | pmid = 10358037 | doi = 10.1074/jbc.274.24.16907 }}
*{{cite journal | author=Leonard AS, Davare MA, Horne MC, ''et al.'' |title=SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. |journal=J. Biol. Chem. |volume=273 |issue= 31 |pages= 19518-24 |year= 1998 |pmid= 9677374 |doi= }}
*{{cite journal |vauthors=Shi SH, Hayashi Y, Petralia RS, Zaman SH, Wenthold RJ, Svoboda K, Malinow R | title = Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. | journal = Science | volume = 284 | issue = 5421 | pages = 1811–6 | year = 1999 | pmid = 10364548 | doi = 10.1126/science.284.5421.1811 }}
*{{cite journal | author=Xiao B, Tu JC, Petralia RS, ''et al.'' |title=Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. |journal=Neuron |volume=21 |issue= 4 |pages= 707-16 |year= 1998 |pmid= 9808458 |doi= }}
*{{cite journal |vauthors=Rubio ME, Wenthold RJ | title = Calnexin and the immunoglobulin binding protein (BiP) coimmunoprecipitate with AMPA receptors. | journal = J. Neurochem. | volume = 73 | issue = 3 | pages = 942–8 | year = 1999 | pmid = 10461883 | doi = 10.1046/j.1471-4159.1999.0730942.x }}
*{{cite journal | author=Montague AA, Greer CA |title=Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb. |journal=J. Comp. Neurol. |volume=405 |issue= 2 |pages= 233-46 |year= 1999 |pmid= 10023812 |doi= }}
*{{cite journal |vauthors=Stinehelfer S, Vruwink M, Burette A | title = Immunolocalization of mGluR1alpha in specific populations of local circuit neurons in the cerebral cortex. | journal = Brain Res. | volume = 861 | issue = 1 | pages = 37–44 | year = 2000 | pmid = 10751563 | doi = 10.1016/S0006-8993(00)01952-1 }}
*{{cite journal | author=Leuschner WD, Hoch W |title=Subtype-specific assembly of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits is mediated by their n-terminal domains. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16907-16 |year= 1999 |pmid= 10358037 |doi= }}
*{{cite journal | author=Shi SH, Hayashi Y, Petralia RS, ''et al.'' |title=Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. |journal=Science |volume=284 |issue= 5421 |pages= 1811-6 |year= 1999 |pmid= 10364548 |doi= }}
*{{cite journal | author=Rubio ME, Wenthold RJ |title=Calnexin and the immunoglobulin binding protein (BiP) coimmunoprecipitate with AMPA receptors. |journal=J. Neurochem. |volume=73 |issue= 3 |pages= 942-8 |year= 1999 |pmid= 10461883 |doi= }}
*{{cite journal  | author=Mahlknecht U, Bucala R, Hoelzer D, Verdin E |title=High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region. |journal=Cytogenet. Cell Genet. |volume=86 |issue= 3-4 |pages= 237-9 |year= 2000 |pmid= 10575214 |doi=  }}
*{{cite journal  | author=Stinehelfer S, Vruwink M, Burette A |title=Immunolocalization of mGluR1alpha in specific populations of local circuit neurons in the cerebral cortex. |journal=Brain Res. |volume=861 |issue= 1 |pages= 37-44 |year= 2000 |pmid= 10751563 |doi=  }}
}}
{{refend}}
{{refend}}


== External links ==
==External links==
* {{MeshName|GRIA1+protein,+human}}
* {{MeshName|GRIA1+protein,+human}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ligand-gated ion channels}}
{{Ligand-gated ion channels}}
[[Category:Ion channels]]
 
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}
 
[[Category:Ionotropic glutamate receptors]]

Latest revision as of 01:24, 10 December 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Glutamate receptor 1 is a protein that in humans is encoded by the GRIA1 gene.[1][2]

Function

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Each of the members (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.[3]

GRIA1 (GluR1) is centrally involved in synaptic plasticity. Expression of the GluR1 gene is significantly reduced in the human frontal cortex with increasing age.[4]

Interactions

GRIA1 has been shown to interact with:

See also

References

  1. ↑ Puckett C, Gomez CM, Korenberg JR, Tung H, Meier TJ, Chen XN, Hood L (October 1991). "Molecular cloning and chromosomal localization of one of the human glutamate receptor genes". Proc Natl Acad Sci U S A. 88 (17): 7557–61. doi:10.1073/pnas.88.17.7557. PMC 52340. PMID 1652753.
  2. ↑ McNamara JO, Eubanks JH, McPherson JD, Wasmuth JJ, Evans GA, Heinemann SF (July 1992). "Chromosomal localization of human glutamate receptor genes". J Neurosci. 12 (7): 2555–62. PMID 1319477.
  3. ↑ "Entrez Gene: GRIA1 glutamate receptor, ionotropic, AMPA 1".
  4. ↑ Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA (June 2004). "Gene regulation and DNA damage in the ageing human brain". Nature. 429 (6994): 883–91. doi:10.1038/nature02661. PMID 15190254.
  5. ↑ Gardoni F, Mauceri D, Fiorentini C, Bellone C, Missale C, Cattabeni F, Di Luca M (November 2003). "CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction". J. Biol. Chem. 278 (45): 44745–52. doi:10.1074/jbc.M303576200. PMID 12933808.
  6. ↑ Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW (July 1998). "SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit". J. Biol. Chem. 273 (31): 19518–24. doi:10.1074/jbc.273.31.19518. PMID 9677374.
  7. ↑ Sans N, Racca C, Petralia RS, Wang YX, McCallum J, Wenthold RJ (October 2001). "Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway". J. Neurosci. 21 (19): 7506–16. PMID 11567040.
  8. ↑ Shen L, Liang F, Walensky LD, Huganir RL (November 2000). "Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association". J. Neurosci. 20 (21): 7932–40. PMID 11050113.
  9. ↑ Kohda K, Kamiya Y, Matsuda S, Kato K, Umemori H, Yuzaki M (January 2003). "Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors". Brain Res. Mol. Brain Res. 110 (1): 27–37. doi:10.1016/s0169-328x(02)00561-2. PMID 12573530.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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