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{{PBB|geneid=9177}}
{{Infobox_gene}}


'''5-hydroxytryptamine (serotonin) receptor 3B''', also known as ''HTR3B'', is a human [[gene]]. The protein encoded by this gene is a subunit of the [[5-HT3 receptor]].<ref name="pmid9950429">{{cite journal | author = Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF | title = The 5-HT3B subunit is a major determinant of serotonin-receptor function | journal = Nature | volume = 397 | issue = 6717 | pages = 359–63 | year = 1999 | month = January | pmid = 9950429 | doi = 10.1038/16941 | url = | issn = }}</ref><ref name="pmid10521471">{{cite journal | author = Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, Jackson MR, Lovenberg TW, Erlander MG | title = The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit | journal = J. Biol. Chem. | volume = 274 | issue = 43 | pages = 30799–810 | year = 1999 | month = October | pmid = 10521471 | doi = 10.1074/jbc.274.43.30799| url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=10521471 | issn = }}</ref>  
'''5-hydroxytryptamine (serotonin) receptor 3B''', also known as ''HTR3B'', is a human [[gene]]. The protein encoded by this gene is a subunit of the [[5-HT3 receptor]].<ref name="pmid9950429">{{cite journal |vauthors=Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF | title = The 5-HT3B subunit is a major determinant of serotonin-receptor function | journal = Nature | volume = 397 | issue = 6717 | pages = 359–63 |date=January 1999 | pmid = 9950429 | doi = 10.1038/16941 | url = }}</ref><ref name="pmid10521471">{{cite journal |vauthors=Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, Jackson MR, Lovenberg TW, Erlander MG | title = The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit | journal = J. Biol. Chem. | volume = 274 | issue = 43 | pages = 30799–810 |date=October 1999 | pmid = 10521471 | doi = 10.1074/jbc.274.43.30799| url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=10521471 }}</ref>


==References==
==References==
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==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal |author=Need AC, Keefe RS, Ge D, ''et al.'' |title=Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. |journal=Eur. J. Hum. Genet. |volume=17 |issue= 7 |pages= 946–57 |year= 2009 |pmid= 19156168 |doi= 10.1038/ejhg.2008.264 }}
*{{cite journal   |vauthors=Need AC, Keefe RS, Ge D, etal |title=Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis |journal=Eur. J. Hum. Genet. |volume=17 |issue= 7 |pages= 946–57 |year= 2009 |pmid= 19156168 |doi= 10.1038/ejhg.2008.264 |pmc=2986499 }}
*{{cite journal |author=Meineke C, Tzvetkov MV, Bokelmann K, ''et al.'' |title=Functional characterization of a -100_-102delAAG deletion-insertion polymorphism in the promoter region of the HTR3B gene. |journal=Pharmacogenet. Genomics |volume=18 |issue= 3 |pages= 219–30 |year= 2008 |pmid= 18300944 |doi= 10.1097/FPC.0b013e3282f51092 }}
*{{cite journal   |vauthors=Meineke C, Tzvetkov MV, Bokelmann K, etal |title=Functional characterization of a -100_-102delAAG deletion-insertion polymorphism in the promoter region of the HTR3B gene |journal=Pharmacogenet. Genomics |volume=18 |issue= 3 |pages= 219–30 |year= 2008 |pmid= 18300944 |doi= 10.1097/FPC.0b013e3282f51092 }}
*{{cite journal |author=Levran O, Londono D, O'Hara K, ''et al.'' |title=Genetic susceptibility to heroin addiction: a candidate gene association study. |journal=[[Genes, Brain and Behavior]] |volume=7 |issue= 7 |pages= 720–9 |year= 2008 |pmid= 18518925 |doi= 10.1111/j.1601-183X.2008.00410.x  |pmc=2885890 }}
*{{cite journal   |vauthors=Levran O, Londono D, O'Hara K, etal |title=Genetic susceptibility to heroin addiction; a candidate-gene association study |journal=[[Genes, Brain and Behavior]] |volume=7 |issue= 7 |pages= 720–9 |year= 2008 |pmid= 18518925 |doi= 10.1111/j.1601-183X.2008.00410.x  |pmc=2885890 }}
*{{cite journal |author=Kato M, Fukuda T, Wakeno M, ''et al.'' |title=Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients. |journal=Neuropsychobiology |volume=53 |issue= 4 |pages= 186–95 |year= 2006 |pmid= 16874005 |doi= 10.1159/000094727 }}
*{{cite journal   |vauthors=Kato M, Fukuda T, Wakeno M, etal |title=Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients |journal=Neuropsychobiology |volume=53 |issue= 4 |pages= 186–95 |year= 2006 |pmid= 16874005 |doi= 10.1159/000094727 }}
*{{cite journal  |author=Hu XQ, Peoples RW |title=The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor. |journal=J. Biol. Chem. |volume=283 |issue= 11 |pages= 6826–31 |year= 2008 |pmid= 18187416 |doi= 10.1074/jbc.M707571200 }}
*{{cite journal  |vauthors=Hu XQ, Peoples RW |title=The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor |journal=J. Biol. Chem. |volume=283 |issue= 11 |pages= 6826–31 |year= 2008 |pmid= 18187416 |doi= 10.1074/jbc.M707571200 }}
*{{cite journal |author=Krzywkowski K, Davies PA, Feinberg-Zadek PL, ''et al.'' |title=High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=105 |issue= 2 |pages= 722–7 |year= 2008 |pmid= 18184810 |doi= 10.1073/pnas.0708454105  |pmc=2206603 }}
*{{cite journal   |vauthors=Krzywkowski K, Davies PA, Feinberg-Zadek PL, etal |title=High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=105 |issue= 2 |pages= 722–7 |year= 2008 |pmid= 18184810 |doi= 10.1073/pnas.0708454105  |pmc=2206603 }}
*{{cite journal |author=Ji X, Takahashi N, Branko A, ''et al.'' |title=An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population. |journal=Nagoya journal of medical science |volume=70 |issue= 1-2 |pages= 11–7 |year= 2008 |pmid= 18807291 |doi=  }}
*{{cite journal   |vauthors=Ji X, Takahashi N, Branko A, etal |title=An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population |journal=Nagoya journal of medical science |volume=70 |issue= 1–2 |pages= 11–7 |year= 2008 |pmid= 18807291 |doi=  }}
*{{cite journal  |author=Kato M, Serretti A |title=Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder. |journal=Mol. Psychiatry |volume= 15|issue=  5|pages= HASH(0x155b370) |year= 2008 |pmid= 18982004 |doi= 10.1038/mp.2008.116 }}
*{{cite journal  |vauthors=Kato M, Serretti A |title=Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder |journal=Mol. Psychiatry |volume= 15|issue=  5|pages= 473–500 |year= 2008 |pmid= 18982004 |doi= 10.1038/mp.2008.116 }}
*{{cite journal |author=Walstab J, Hammer C, Bönisch H, ''et al.'' |title=Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptors. |journal=Pharmacogenet. Genomics |volume=18 |issue= 9 |pages= 793–802 |year= 2008 |pmid= 18698232 |doi= 10.1097/FPC.0b013e3283050117 }}
*{{cite journal   |vauthors=Walstab J, Hammer C, Bönisch H, etal |title=Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptors |journal=Pharmacogenet. Genomics |volume=18 |issue= 9 |pages= 793–802 |year= 2008 |pmid= 18698232 |doi= 10.1097/FPC.0b013e3283050117 }}
*{{cite journal |author=Yosifova A, Mushiroda T, Stoianov D, ''et al.'' |title=Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. |journal=Journal of affective disorders |volume=117 |issue= 1-2 |pages= 87–97 |year= 2009 |pmid= 19328558 |doi= 10.1016/j.jad.2008.12.021 }}
*{{cite journal   |vauthors=Yosifova A, Mushiroda T, Stoianov D, etal |title=Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population |journal=Journal of Affective Disorders |volume=117 |issue= 1–2 |pages= 87–97 |year= 2009 |pmid= 19328558 |doi= 10.1016/j.jad.2008.12.021 }}
*{{cite journal |author=Tzvetkov MV, Meineke C, Oetjen E, ''et al.'' |title=Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine. |journal=Gene |volume=386 |issue= 1-2 |pages= 52–62 |year= 2007 |pmid= 17010535 |doi= 10.1016/j.gene.2006.08.002 }}
*{{cite journal   |vauthors=Tzvetkov MV, Meineke C, Oetjen E, etal |title=Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine |journal=Gene |volume=386 |issue= 1–2 |pages= 52–62 |year= 2007 |pmid= 17010535 |doi= 10.1016/j.gene.2006.08.002 }}
*{{cite journal |author=Oades RD, Lasky-Su J, Christiansen H, ''et al.'' |title=The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis. |journal=Behavioral and brain functions : BBF |volume=4 |issue=  |pages= 48 |year= 2008 |pmid= 18937842 |doi= 10.1186/1744-9081-4-48  |pmc=2577091 }}
*{{cite journal   |vauthors=Oades RD, Lasky-Su J, Christiansen H, etal |title=The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis |journal=Behavioral and Brain Functions |volume=4 |issue=  |pages= 48 |year= 2008 |pmid= 18937842 |doi= 10.1186/1744-9081-4-48  |pmc=2577091 }}
*{{cite journal |author=Fasching PA, Kollmannsberger B, Strissel PL, ''et al.'' |title=Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. |journal=J. Cancer Res. Clin. Oncol. |volume=134 |issue= 10 |pages= 1079–86 |year= 2008 |pmid= 18389280 |doi= 10.1007/s00432-008-0387-1 }}
*{{cite journal   |vauthors=Fasching PA, Kollmannsberger B, Strissel PL, etal |title=Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy |journal=J. Cancer Res. Clin. Oncol. |volume=134 |issue= 10 |pages= 1079–86 |year= 2008 |pmid= 18389280 |doi= 10.1007/s00432-008-0387-1 }}
*{{cite journal |author=Tanaka M, Kobayashi D, Murakami Y, ''et al.'' |title=Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea. |journal=Int. J. Neuropsychopharmacol. |volume=11 |issue= 2 |pages= 261–7 |year= 2008 |pmid= 17697394 |doi= 10.1017/S1461145707007985 }}
*{{cite journal   |vauthors=Tanaka M, Kobayashi D, Murakami Y, etal |title=Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea |journal=Int. J. Neuropsychopharmacol. |volume=11 |issue= 2 |pages= 261–7 |year= 2008 |pmid= 17697394 |doi= 10.1017/S1461145707007985 }}
*{{cite journal |author=Gratacòs M, Costas J, de Cid R, ''et al.'' |title=Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=150B |issue= 6 |pages= 808–16 |year= 2009 |pmid= 19086053 |doi= 10.1002/ajmg.b.30902 }}
*{{cite journal   |vauthors=Gratacòs M, Costas J, de Cid R, etal |title=Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=150B |issue= 6 |pages= 808–16 |year= 2009 |pmid= 19086053 |doi= 10.1002/ajmg.b.30902 }}
*{{cite journal |author=Krzywkowski K, Davies PA, Irving AJ, ''et al.'' |title=Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling. |journal=Pharmacogenet. Genomics |volume=18 |issue= 12 |pages= 1027–40 |year= 2008 |pmid= 19008750 |doi= 10.1097/FPC.0b013e328310f950 }}
*{{cite journal   |vauthors=Krzywkowski K, Davies PA, Irving AJ, etal |title=Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling |journal=Pharmacogenet. Genomics |volume=18 |issue= 12 |pages= 1027–40 |year= 2008 |pmid= 19008750 |doi= 10.1097/FPC.0b013e328310f950 }}
*{{cite journal |author=Smith AK, Dimulescu I, Falkenberg VR, ''et al.'' |title=Genetic evaluation of the serotonergic system in chronic fatigue syndrome. |journal=Psychoneuroendocrinology |volume=33 |issue= 2 |pages= 188–97 |year= 2008 |pmid= 18079067 |doi= 10.1016/j.psyneuen.2007.11.001 }}
*{{cite journal   |vauthors=Smith AK, Dimulescu I, Falkenberg VR, etal |title=Genetic evaluation of the serotonergic system in chronic fatigue syndrome |journal=Psychoneuroendocrinology |volume=33 |issue= 2 |pages= 188–97 |year= 2008 |pmid= 18079067 |doi= 10.1016/j.psyneuen.2007.11.001 }}
*{{cite journal |author=de Krom M, Staal WG, Ophoff RA, ''et al.'' |title=A common variant in DRD3 receptor is associated with autism spectrum disorder. |journal=Biol. Psychiatry |volume=65 |issue= 7 |pages= 625–30 |year= 2009 |pmid= 19058789 |doi= 10.1016/j.biopsych.2008.09.035 }}
*{{cite journal   |vauthors=de Krom M, Staal WG, Ophoff RA, etal |title=A common variant in DRD3 receptor is associated with autism spectrum disorder |journal=Biol. Psychiatry |volume=65 |issue= 7 |pages= 625–30 |year= 2009 |pmid= 19058789 |doi= 10.1016/j.biopsych.2008.09.035 }}
*{{cite journal |author=Ducci F, Enoch MA, Yuan Q, ''et al.'' |title=HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power--an intermediate phenotype for alcoholism and co-morbid behaviors. |journal=Alcohol |volume=43 |issue= 1 |pages= 73–84 |year= 2009 |pmid= 19185213 |doi= 10.1016/j.alcohol.2008.09.005  |pmc=2754808 }}
*{{cite journal   |vauthors=Ducci F, Enoch MA, Yuan Q, etal |title=HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power—an intermediate phenotype for alcoholism and co-morbid behaviors |journal=Alcohol |volume=43 |issue= 1 |pages= 73–84 |year= 2009 |pmid= 19185213 |doi= 10.1016/j.alcohol.2008.09.005  |pmc=2754808 }}
{{refend}}
{{refend}}


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* {{MeshName|HTR3B+protein,+human}}
* {{MeshName|HTR3B+protein,+human}}


{{transmembranereceptor-stub}}
{{Ligand-gated ion channels}}
{{Ligand-gated ion channels}}
[[Category:Neurotransmitters]]
 
[[Category:Serotonin receptors]]
[[Category:Ion channels]]
[[Category:Ion channels]]
[[Category:Ionotropic receptors]]
 
 
{{transmembranereceptor-stub}}

Latest revision as of 22:34, 3 April 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

5-hydroxytryptamine (serotonin) receptor 3B, also known as HTR3B, is a human gene. The protein encoded by this gene is a subunit of the 5-HT3 receptor.[1][2]

References

  1. ↑ Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF (January 1999). "The 5-HT3B subunit is a major determinant of serotonin-receptor function". Nature. 397 (6717): 359–63. doi:10.1038/16941. PMID 9950429.
  2. ↑ Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, Jackson MR, Lovenberg TW, Erlander MG (October 1999). "The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit". J. Biol. Chem. 274 (43): 30799–810. doi:10.1074/jbc.274.43.30799. PMID 10521471.

Further reading

External links


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