Ileus medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]
Overview
The majority of cases of ileus are resolved with correction of underlying electrolyte disorder and only require supportive care. Intravenous hydration is advised with appropriate rapid supplementation for electrolyte abnormalities. NSAIDs are used as baseline analgesic medications. In contrast, opiates and antimotility drugs (such as vagolytic agents) should be avoided generally, although opiates are sometimes used in case of severe intractable pain. Patients are put on NPO and nasogastric tube is advised to relieve recurrent vomiting or abdominal distention associated with pain. Prokinetic agents such as erythromycin are not routinely recommended. In paralytic ilues certain medications such as hyoscyamine, methscopolamine bromide, oxycodone, polyethylene glycol-electrolyte solution (PEG-ES) are contraindicated.
Medical Therapy
Medical therapy for ileus includes correcting the underlying condition and supportive therapy.[1][2][3][4]
- Patients should receive intravenous hydration.
- Patients of ileus from electrolyte abnormalities should be treated with appropriate supplementation.
- Bowel rest and nasogastric decompression can relieve recurrent vomiting or abdominal distention associated with pain.[5][6]
- Antimotility drugs (such as vagolytic agents (butylscopolamine) and other medications (narcotics) which may alter intestinal motility should be stopped.
- Prokinetic agents such as erythromycin are not routinely recommended.
- 1.1 - Post-operative pain
- Preferred regimen (1): Acetaminophen 1000 mg orally every six hours (or IV when patient is NPO).
- Preferred regimen (2): Add diclofenac 50 mg orally twice a day with meals for two days and adjust as-needed.
- Preferred regimen (3): Add oxycodone 5 to 10 mg orally every three hours as needed for breakthrough pain.
- Alternate regimen (1): Hydromorphone 0.2 to 0.5 mg IV every four hours as needed for severe breakthrough pain not responsive to oral medications.
- 1.2 Fluid replacement
- 1.3 Recurrent vomiting or abdominal distension
- 1.1 - Post-operative pain
Contraindicated medications
Paralytic ileus is considered an absolute contraindication to the use of the following medications:
References
- ↑ Bruns BR, Kozar RA (2016). "Feeding the Postoperative Patient on Vasopressor Support: Feeding and Pressor Support". Nutr Clin Pract. 31 (1): 14–7. doi:10.1177/0884533615619932. PMID 26703957.
- ↑ Cali RL, Meade PG, Swanson MS, Freeman C (2000). "Effect of Morphine and incision length on bowel function after colectomy". Dis. Colon Rectum. 43 (2): 163–8. PMID 10696888.
- ↑ Wu Z, Boersema GS, Dereci A, Menon AG, Jeekel J, Lange JF (2015). "Clinical endpoint, early detection, and differential diagnosis of postoperative ileus: a systematic review of the literature". Eur Surg Res. 54 (3–4): 127–38. doi:10.1159/000369529. PMID 25503902.
- ↑ Lubawski J, Saclarides T (2008). "Postoperative ileus: strategies for reduction". Ther Clin Risk Manag. 4 (5): 913–7. PMC 2621410. PMID 19209273.
- ↑ Kehlet H, Williamson R, Büchler MW, Beart RW (2005). "A survey of perceptions and attitudes among European surgeons towards the clinical impact and management of postoperative ileus". Colorectal Dis. 7 (3): 245–50. doi:10.1111/j.1463-1318.2005.00763.x. PMID 15859962.
- ↑ Kehlet H, Büchler MW, Beart RW, Billingham RP, Williamson R (2006). "Care after colonic operation--is it evidence-based? Results from a multinational survey in Europe and the United States". J. Am. Coll. Surg. 202 (1): 45–54. doi:10.1016/j.jamcollsurg.2005.08.006. PMID 16377496.