Epithelium

(Redirected from Epithelial cells)
Jump to navigation Jump to search

WikiDoc Resources for Epithelium

Articles

Most recent articles on Epithelium

Most cited articles on Epithelium

Review articles on Epithelium

Articles on Epithelium in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Epithelium

Images of Epithelium

Photos of Epithelium

Podcasts & MP3s on Epithelium

Videos on Epithelium

Evidence Based Medicine

Cochrane Collaboration on Epithelium

Bandolier on Epithelium

TRIP on Epithelium

Clinical Trials

Ongoing Trials on Epithelium at Clinical Trials.gov

Trial results on Epithelium

Clinical Trials on Epithelium at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Epithelium

NICE Guidance on Epithelium

NHS PRODIGY Guidance

FDA on Epithelium

CDC on Epithelium

Books

Books on Epithelium

News

Epithelium in the news

Be alerted to news on Epithelium

News trends on Epithelium

Commentary

Blogs on Epithelium

Definitions

Definitions of Epithelium

Patient Resources / Community

Patient resources on Epithelium

Discussion groups on Epithelium

Patient Handouts on Epithelium

Directions to Hospitals Treating Epithelium

Risk calculators and risk factors for Epithelium

Healthcare Provider Resources

Symptoms of Epithelium

Causes & Risk Factors for Epithelium

Diagnostic studies for Epithelium

Treatment of Epithelium

Continuing Medical Education (CME)

CME Programs on Epithelium

International

Epithelium en Espanol

Epithelium en Francais

Business

Epithelium in the Marketplace

Patents on Epithelium

Experimental / Informatics

List of terms related to Epithelium

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]



Overview

Types of epithelium

In biology and medicine, epithelium is a tissue composed of a layer of cells. Epithelium lines both the outside (skin) and the inside cavities and lumen of bodies. The outermost layer of our skin is composed of dead stratified squamous, keratinized epithelial cells.

Mucous membranes lining the inside of the mouth, the esophagus, and part of the rectum are lined by nonkeratinized stratified squamous epithelium. Other, open to outside body cavities are lined by simple squamous or columnar epithelial cells.

Other epithelial cells line the insides of the lungs, the gastrointestinal tract, the reproductive and urinary tracts, and make up the exocrine and endocrine glands. The outer surface of the cornea is covered with fast-growing, easily-regenerated epithelial cells.

Functions of epithelial cells include secretion, absorption, protection, transcellular transport, sensation detection, and selective permeability.

Endothelium (the inner lining of blood vessels, the heart, and lymphatic vessels) is a specialized form of epithelium. Another type, Mesothelium, forms the walls of the pericardium, pleurae, and peritoneum.

In humans, epithelium is classified as a primary body tissue, the other ones being connective tissue, muscle tissue and nervous tissue.

Classification

Epithelial cells are classified by the following three factors:

  • Shape
  • Stratification
  • Specializations

Shape

  • Squamous: All Squamous cells are flat cells with an irregular flattened shape. A one-cell layer of simple squamous epithelium forms the alveoli of the respiratory membrane, and the endothelium of capillaries, and is a minimal barrier to diffusion. Other places where squamous cells can be found include the filtration tubules of the kidneys, and the major cavities of the body. These cells are relatively inactive metabolically, and are associated with the diffusion of water, electrolytes, and other substances.
  • Cuboidal: As the name suggests, these cells have a shape similar to a cube, meaning its width is the same size as its height. The nuclei of these cells are usually located in the center.
  • Columnar: These cells are taller than they are wide. Simple columnar epithelium is made up of a single layer of cells that are longer than they are wide. The nucleus is also closer to the base of the cell. The small intestine is a tubular organ lined with this type of tissue. Unicellular glands called goblet cells are scattered throughout the simple columnar epithelial cells and secrete mucus. The free surface of the columnar cell has tiny hairlike projections called microvilli. They increase the surface area for absorption.
  • Transitional: This is a specialized type of epithelium found lining organs that can stretch, such as the urothelium that lines the bladder and ureter of mammals. Since the cells can slide over each other, the appearance of this epithelium depends on whether the organ is distended or contracted: if distended, it appears as if there are only a few layers; when contracted, it appears as if there are several layers.

Stratification

  • Simple: There is a single layer of cells.
  • Stratified: More than one layer of cells. The superficial layer is used to classify the layer. Only one layer touches the basal lamina. Stratified cells can usually withstand large amounts of stress.
  • Pseudostratified with cilia: This is used mainly in one type of classification (pseudostratified columnar epithelium). There is only a single layer of cells, but the position of the nuclei gives the impression that it is stratified. If a specimen looks stratified, but you can identify cilia, the specimen is pseudostratified ciliated epithelium since stratified epithelium cannot have cilia but may be very rarely found in fetal oesophagus. A cell that contains hairs will be around ten times stronger than a regular cell

Specializations

  • Keratinized cells contain keratin (a cytoskeletal protein). While keratinized epithelium occurs mainly in the skin, it is also found in the mouth and nose, providing a tough, impermeable barrier.

Headline text

Examples

System Tissue Epithelium Subtype
circulatory blood vessels Simple squamous endothelium
digestive ducts of submandibular glands Stratified columnar -
digestive attached gingiva Stratified squamous, keratinized -
digestive dorsum of tongue Stratified squamous, keratinized -
digestive hard palate Stratified squamous, keratinized -
digestive esophagus Stratified squamous, non-keratinised -
digestive stomach Simple columnar, non-ciliated -
digestive small intestine Simple columnar, non-ciliated -
digestive large intestine Simple columnar, non-ciliated -
digestive rectum Stratified squamous, non-keratinised -
digestive anus Stratified squamous, keratinised -
digestive gallbladder Simple columnar, non-ciliated -
endocrine thyroid follicles Simple cuboidal -
nervous ependyma Simple cuboidal -
lymphatic lymph vessel Simple squamous endothelium
integumentary skin - dead superficial layer Stratified squamous, keratinized -
integumentary sweat gland ducts Stratified cuboidal -
integumentary mesothelium of body cavities Simple squamous -
reproductive - female ovaries Simple cuboidal germinal epithelium (female)
reproductive - female Fallopian tubes Simple columnar, ciliated -
reproductive - female uterus Simple columnar, ciliated -
reproductive - female endometrium Simple columnar -
reproductive - female cervix (endocervix) Simple columnar -
reproductive - female cervix (ectocervix) Stratified squamous, non-keratinised -
reproductive - female vagina Stratified squamous, non-keratinised -
reproductive - female labia majora Stratified squamous, keratinised -
reproductive - male tubuli recti Simple cuboidal germinal epithelium (male)
reproductive - male rete testis Simple cuboidal -
reproductive - male ductuli efferentes Pseudostratified columnar -
reproductive - male epididymis Pseudostratified columnar, with stereocilia -
reproductive - male vas deferens Pseudostratified columnar -
reproductive - male ejaculatory duct Simple columnar -
reproductive - male (gland) bulbourethral glands Simple columnar -
reproductive - male (gland) seminal vesicle Pseudostratified columnar -
respiratory oropharynx Stratified squamous, non-keratinised -
respiratory larynx Pseudostratified columnar, ciliated respiratory epithelium
respiratory trachea Pseudostratified columnar, ciliated respiratory epithelium
respiratory respiratory bronchioles Simple cuboidal -
sensory cornea Stratified squamous, non-keratinised corneal epithelium
sensory nose Pseudostratified columnar olfactory epithelium
urinary kidney - proximal convoluted tubule Simple columnar, ciliated -
urinary kidney - ascending thin limb Simple squamous -
urinary kidney - distal convoluted tubule Simple columnar, non-ciliated -
urinary kidney - collecting duct Simple cuboidal -
urinary renal pelvis Transitional urothelium
urinary ureter Transitional urothelium
urinary urinary bladder Transitional urothelium
urinary prostatic urethra Transitional urothelium
urinary membranous urethra Pseudostratified columnar, non-ciliated -
urinary penile urethra Pseudostratified columnar, non-ciliated -
urinary external urethral orifice Stratified squamous -

Cell junctions

A cell junction is a structure within a tissue of a multicellular organism. Cell junctions are especially abundant in epithelial tissues. They consist of protein complexes and provide contact between neighbouring cells, between a cell and the extracellular matrix, or they built up the paracellular barrier of epithelia and control the paracellular transport.

Secretory epithelia

As stated above, secretion is one major function of epithelial cells. Glands are formed from the invagination / infolding of epithelial cells and subsequent growth in the underlying connective tissue. There are two major classification of glands: endocrine glands and exocrine glands. Endocrine glands are glands that secrete their product directly onto a surface rather than through a duct. This group contains the glands of the Endocrine system

Embryology

Generally, there are epithelial tissues deriving from all of the embryological germ layers:

However, it is important to note that pathologists do not consider endothelium and mesothelium (both derived from mesoderm) to be true epithelium. This is because such tissues present very different pathology. For that reason, pathologists label cancers in endothelium and mesothelium sarcomas, while true epithelial cancers are called carcinomas. Also, the filaments that support these mesodermally derived tissues are very distinct. Outside of the field of pathology, the idea that epithelium arise from all three germ layers is generally accepted

Additional images

Links

References

  • Molecular Biology of the Cell, 4th edition, Alberts et al., 2002

Template:Biological tissue

Template:TissueLayers


bg:Епителна тъкан cs:Epitelová tkáň da:Epitel de:Epithel eu:Epitelio ehun ko:상피세포 id:Jaringan epitel it:Tessuto epiteliale he:אפיתל lv:Epitēlijaudi lt:Epitelinis audinys nl:Epitheel no:Epitel nn:Epitel sk:Epitel sl:Krovno tkivo sr:Епителско ткиво fi:Epiteelikudos sv:Epitel th:เนื้อเยื่อบุผิว tg:Бофтаи эпителӣ uk:Епітелій


Template:WikiDoc Sources