Cerebral salt-wasting syndrome

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Cerebral salt-wasting syndrome Classification and external resources
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Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch. Cerebral salt-wasting syndrome (CSWS) is a disease featuring hyponatremia (low blood sodium levels) and dehydration in response to disease processes in or surrounding the brain.

Differential diagnosis

It may be difficult to distinguish from the syndrome of inappropriate antidiuretic hormone (SIADH), which develops under similar circumstances and also presents with hyponatremia.

The main clinical difference between these two conditions is that of total fluid status of the patient: CSWS leads to a relative or overt hypovolemia, whereas SIADH is consistent with a normal to hypervolemic patient. ^[1]

Another useful point in differentiating CSWS from SIADH is a laboratory finding: random urine sodium concentrations tend to be >100 mEq/L in CSWS. SIADH rarely, if ever, leads to a random urine sodium of >100 mEq/L.

Treatment

The reason for the abnormality is different, and treatments are opposites: fluid restriction is used in SIADH, which would worsen cerebral salt wasting. Instead, CSWS is treated with fluids and correction of the low sodium.

Sometimes, fludrocortisone (a mineralocorticoid) improves the hyponatremia.^[1]

References

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Articles on Cerebral salt-wasting syndrome	Most recent articles on Cerebral salt-wasting syndrome • Most cited articles on Cerebral salt-wasting syndrome • Review articles on Cerebral salt-wasting syndrome • Articles on Cerebral salt-wasting syndrome in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Cerebral salt-wasting syndrome	Powerpoint slides on Cerebral salt-wasting syndrome • Images of Cerebral salt-wasting syndrome • Photos of Cerebral salt-wasting syndrome • Podcasts & MP3s on Cerebral salt-wasting syndrome • Videos on Cerebral salt-wasting syndrome
Evidence Based Medicine Regarding Cerebral salt-wasting syndrome	Cochrane Collaboration on Cerebral salt-wasting syndrome • Bandolier on Cerebral salt-wasting syndrome • TRIP on Cerebral salt-wasting syndrome
Cost Effectiveness of Cerebral salt-wasting syndrome	Cost Effectiveness of Cerebral salt-wasting syndrome
Clinical Trials Involving Cerebral salt-wasting syndrome	Ongoing Trials on Cerebral salt-wasting syndrome at Clinical Trials.gov • Trial results on Cerebral salt-wasting syndrome • Clinical Trials on Cerebral salt-wasting syndrome at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Cerebral salt-wasting syndrome	US National Guidelines Clearinghouse on Cerebral salt-wasting syndrome • NICE Guidance on Cerebral salt-wasting syndrome • NHS PRODIGY Guidance • FDA on Cerebral salt-wasting syndrome • CDC on Cerebral salt-wasting syndrome
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Genetics, Pharmacogenomics, and Proteinomics of Cerebral salt-wasting syndrome	Genetics of Cerebral salt-wasting syndrome • Pharmacogenomics of Cerebral salt-wasting syndrome • Proteomics of Cerebral salt-wasting syndrome
Newstories on Cerebral salt-wasting syndrome	Cerebral salt-wasting syndrome in the news • Be alerted to news on Cerebral salt-wasting syndrome • News trends on Cerebral salt-wasting syndrome
Commentary on Cerebral salt-wasting syndrome	Blogs on Cerebral salt-wasting syndrome
Patient Resources on Cerebral salt-wasting syndrome	Patient resources on Cerebral salt-wasting syndrome • Discussion groups on Cerebral salt-wasting syndrome • Patient Handouts on Cerebral salt-wasting syndrome • Directions to Hospitals Treating Cerebral salt-wasting syndrome • Risk calculators and risk factors for Cerebral salt-wasting syndrome
Healthcare Provider Resources on Cerebral salt-wasting syndrome	Symptoms of Cerebral salt-wasting syndrome • Causes & Risk Factors for Cerebral salt-wasting syndrome • Diagnostic studies for Cerebral salt-wasting syndrome • Treatment of Cerebral salt-wasting syndrome
Continuing Medical Education (CME) Programs on Cerebral salt-wasting syndrome	CME Programs on Cerebral salt-wasting syndrome
International Resources on Cerebral salt-wasting syndrome	Cerebral salt-wasting syndrome en Espanol • Cerebral salt-wasting syndrome en Francais
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