Tumor lysis syndrome causes: Difference between revisions

	Tumor lysis syndrome Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Tumor lysis syndrome from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Criteria
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Tumor lysis syndrome causes On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Tumor lysis syndrome causes All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Tumor lysis syndrome causes
CDC on Tumor lysis syndrome causes
Tumor lysis syndrome causes in the news
Blogs on Tumor lysis syndrome causes
Directions to Hospitals Treating Tumor lysis syndrome
Risk calculators and risk factors for Tumor lysis syndrome causes

VisualWikitext

Latest revision as of 13:42, 7 September 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Nazia Fuad M.D.

Overview

Development of tumor lysis syndrome is the result of initiation of chemotherapy or radiotherapy in cancer patients. The most common causes of tumor lysis syndrome are Burkitt's lymphoma , acute lymphoblastic leukemia , acute myeloid leukemia and chemotherapy including methotrexate. Sometimes it can occur spontaneously without administration of treatment primarily in patients with non-Hodgkin lymphoma (NHL) or acute leukemia.

Causes

Common Causes

The most common causes of tumor lysis syndrome are:^[1]^[2]

Less common causes

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Bortezomib, Carfilzomib, Cytarabine, cytotoxic chemotherapy, Doxorubicin Hydrochloride etoposide, fludarabine, glucocorticoids, hydroxyurea, Ibrutinib, imatinib, lenalidomide , Nelarabine, Nilotinib, Ofatumumab, paclitaxel, Pralatrexate, rituximab, thalidomide, Vincristine sulfate liposome zoledronic acid
Ear Nose Throat	No underlying causes
Endocrine	No underlying causes
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	No underlying causes
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	Acute lymphoblastic leukemia , acute myeloid leukemia, adult T-cell leukemia/lymphoma , anaplastic large cell lymphoma, breast cancer , Burkitt's lymphoma, chronic myeloid leukemia, diffuse large B-cell lymphoma, gastrointestinal stromal tumors, germ cell tumors , hepatoblastoma, hepatocellular carcinoma, hodgkin's disease, isolated plasmacytomas, mantle cell lymphoma, medulloblastoma, melanoma, metastatic colorectal cancer , multiple myeloma, neuroblastoma, Non-Hodgkin lymphoma, ovarian cancer , rhabdomyosarcoma, sarcoma, small cell lung cancer, squamous cell carcinoma of the vulva, thalidomide, transformed lymphoma, urothelial cancer
Ophthalmologic	No underlying causes
Overdose/Toxicity
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte
Rheumatology/Immunology/Allergy	No underlying causes\|-
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes by Alphabetical Order

References

↑ "www.asn-online.org" (PDF).
↑ Howard SC, Jones DP, Pui CH (May 2011). "The tumor lysis syndrome". N. Engl. J. Med. 364 (19): 1844–54. doi:10.1056/NEJMra0904569. PMC 3437249. PMID 21561350.

Template:WH Template:WS

[urlwww.asn-online.org-1] "www.asn-online.org" (PDF).

[pmid21561350-2] Howard SC, Jones DP, Pui CH (May 2011). "The tumor lysis syndrome". N. Engl. J. Med. 364 (19): 1844–54. doi:10.1056/NEJMra0904569. PMC 3437249. PMID 21561350.

[1]

[2]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Tumor lysis syndrome}}
-{{CMG}}
+{{CMG}}  {{N.F}}
 ==Overview==
-Tumor lysis syndrome (TLS) is a group of metabolic abnormalities resulting from rapid lysis of malignant cells and massive release of cell breakdown products into the blood among patients with hematologic malignancies treated with chemotherapy.  The most common tumors associated with this syndrome are poorly differentiated lymphomas, such as [[Burkitt's lymphoma]], and leukemias, such as [[acute lymphoblastic leukemia]] (ALL) and [[acute myeloid leukemia]] (AML).  Usually, the precipitating medication regimen includes combination [[chemotherapy]], but those patients with lymphoma and ALL can be affected with [[steroid]] treatment alone.
+Development of tumor lysis syndrome is the result of initiation of [[chemotherapy]] or [[radiotherapy]] in cancer patients. The most common causes of tumor lysis syndrome are [[Burkitt's lymphoma]][[Acute lymphoblastic leukemia|, acute lymphoblastic leukemia]][[Acute myeloid leukemia|, acute myeloid leukemia]] and [[chemotherapy]] including [[methotrexate]]. Sometimes it can occur spontaneously  without administration of treatment primarily in patients with non-Hodgkin lymphoma (NHL) or acute leukemia.
 ==Causes==
-===Life Threatening Causes===
-Life-threatening conditions may result in death or permanent disability within 24 hours if left untreated.  Tumor lysis syndrome is a life-threatening condition and must be treated as such irrespective of the causes.
 ===Common Causes===
+The most common causes of tumor lysis syndrome are:<ref name="urlwww.asn-online.org">{{cite web |url=https://www.asn-online.org/education/distancelearning/curricula/onco/Chapter4.pdf |title=www.asn-online.org |format= |work= |accessdate=}}</ref><ref name="pmid21561350">{{cite journal |vauthors=Howard SC, Jones DP, Pui CH |title=The tumor lysis syndrome |journal=N. Engl. J. Med. |volume=364 |issue=19 |pages=1844–54 |date=May 2011 |pmid=21561350 |pmc=3437249 |doi=10.1056/NEJMra0904569 |url=}}</ref>
 *[[Burkitt's lymphoma]]
 *[[Acute lymphoblastic leukemia]]
 *[[Acute myeloid leukemia]]
-*[[Chemotherapy]]
+*[[Chemotherapy]] including [[methotrexate]]
+=== Less common causes ===
+* Solid tumor
+* [[Myeloma]]
+* [[Chronic leukemia|Chronic myeloid leukemia CML]]
+* CLL [[chronic lymphocytic leukemia]]
+* [[Hodgkin lymphoma]]
+* [[Small lymphocytic lymphoma]]
+* [[Marginal zone lymphoma|Marginal zone B cell]]
+* [[MALT lymphoma|MALT]]
+* Nonblastoid mantle cell
+* [[Cutaneous T cell lymphoma|Cutaneous T cell]]
+* [[Adult T-cell leukemia]]
 ===Causes by Organ System===
-{|style="width:80%; height:100px" border="1"
+{| style="width:80%; height:100px" border="1"
-|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
+| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
-|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
+| style="width:75%" bgcolor="Beige" ; border="1" | No underlying causes
 |-
-|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
+| bgcolor="LightSteelBlue" | '''Chemical/Poisoning'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Dental'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Dermatologic'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Drug Side Effect'''
-|bgcolor="Beige"|
+| bgcolor="Beige" |
 [[Bortezomib]],
+[[Carfilzomib]],
+[[Cytarabine]],
 [[Chemotherapy|cytotoxic chemotherapy]],
+[[Doxorubicin Hydrochloride]]
 [[etoposide]],
 [[fludarabine]],
 [[glucocorticoids]],
 [[hydroxyurea]],
+[[Ibrutinib]],
 [[imatinib]],
-[[lenalidomide ]],
+[[lenalidomide ]] ,
+[[Nelarabine]],
+[[Nilotinib]],
+[[Ofatumumab]],
 [[paclitaxel]],
+[[Pralatrexate]],
 [[rituximab]],
+[[thalidomide]],
+[[Vincristine sulfate liposome]]
 [[zoledronic acid]]
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Ear Nose Throat'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Endocrine'''
-|bgcolor="Beige"|
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Environmental'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Gastroenterologic'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Genetic'''
-|bgcolor="Beige"|
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Hematologic'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Iatrogenic'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Infectious Disease'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Musculoskeletal/Orthopedic'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Neurologic'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Nutritional/Metabolic'''
-|bgcolor="Beige"|
+| bgcolor="Beige" | No underlying causes
-|-
+|- bgcolor="LightSteelBlue"
-|-bgcolor="LightSteelBlue"
 | '''Obstetric/Gynecologic'''
-|bgcolor="Beige"|
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Oncologic'''
-|bgcolor="Beige"|
+| bgcolor="Beige" |
-[[Acute lymphoblastic leukemia ]],
+[[Acute lymphoblastic leukemia ]] ,
 [[acute myeloid leukemia]],
-[[adult T-cell leukemia/lymphoma ]],
+[[adult T-cell leukemia/lymphoma ]] ,
 [[anaplastic large cell lymphoma]],
-[[breast cancer ]],
+[[breast cancer ]] ,
 [[Burkitt's lymphoma]],
 [[chronic myeloid leukemia]],
 [[diffuse large B-cell lymphoma]],
 [[gastrointestinal stromal tumors]],
-[[germ cell tumors ]],
+[[germ cell tumors ]] ,
 [[hepatoblastoma]],
 [[hepatocellular carcinoma]],
@@ Line 112: / Line 135: @@
 [[medulloblastoma]],
 [[melanoma]],
-[[Colorectal cancer|metastatic colorectal cancer ]],
+[[Colorectal cancer|metastatic colorectal cancer]] ,
 [[multiple myeloma]],
 [[neuroblastoma]],
 [[Non-Hodgkin lymphoma]],
-[[ovarian cancer ]],
+[[ovarian cancer ]] ,
 [[rhabdomyosarcoma]],
 [[sarcoma]],
@@ Line 123: / Line 146: @@
 [[thalidomide]],
 [[Richter's transformation|transformed lymphoma]],
-[[Transitional cell carcinoma|urothelial cancer ]]
+[[Transitional cell carcinoma|urothelial cancer]]
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Ophthalmologic'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Overdose/Toxicity'''
-|bgcolor="Beige"|
+| bgcolor="Beige" |
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Psychiatric'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Pulmonary'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Renal/Electrolyte'''
-|bgcolor="Beige"|
+| bgcolor="Beige" |
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Rheumatology/Immunology/Allergy'''
-|bgcolor="Beige"|
+| bgcolor="Beige" |
-|-
+No underlying causes|-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Sexual'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Trauma'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Urologic'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
-|-bgcolor="LightSteelBlue"
+|- bgcolor="LightSteelBlue"
 | '''Miscellaneous'''
-|bgcolor="Beige"| No underlying causes
+| bgcolor="Beige" | No underlying causes
 |-
 |}
@@ Line 178: / Line 201: @@
 *[[Burkitt lymphoma]]
 *[[Chronic myeloid leukemia]]
+*[[Cytarabine]]
 *[[Chemotherapy|Cytotoxic chemotherapy]]
 *[[Diffuse large B-cell lymphoma]]
+*[[Doxorubicin Hydrochloride]]
 *[[Etoposide]]
 *[[Fludarabine]]
@@ Line 203: / Line 228: @@
 *[[Ovarian cancer ]]
 *[[Paclitaxel]]
+*[[Pralatrexate]]
 *[[Radiation therapy ]]
 *[[Rhabdomyosarcoma]]
@@ Line 223: / Line 249: @@
 [[Category:Oncology]]
 [[Category:Hematology]]
+ [[Category:Up-To-Date]]
+[[Category:Oncology]]
+[[Category:Medicine]]