Tricuspid regurgitation epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]

Overview

Tricuspid regurgitation of mild degree is common in individuals with anatomically normal valves and it has no physiological consequence.[1] The prevalence of tricuspid regurgitation (TR) of a severity ≥ mild is approximately 15% in men and 18% in women.[2] Secondary TR is more common than primary TR.[3]

Prevalence

Secondary Tricuspid regurgitation constitutes about 80% of significant TR.[1] The Framingham Heart Study, a prospective epidemiologic study, evaluated the prevalence and severity of TR and other valvular diseases by color Doppler examinations in 1,696 men and 1,893 women. The study revealed that TR is the second most common valvular regurgitation in the general population, after mitral regurgitation. The prevalence of TR (with a severity ranging from trace to ≥ moderate regurgitation) was 82% in men and 85.7% in women. When trace regurgitation is excluded, the prevalence of TR of a severity ≥ mild was 14.8% in men and 18.4% in women. The elevated prevalence of trace regurgitation can be a normal finding related to an artifact or an anatomic characteristic of the closure of the tricuspid valve.[2]

Age

The prevalence of TR increases with age. Shown below are tables depicting the prevalence of TR by age and severity in men and women according the results of the Framingham Heart Study.[2]

Severity of TR Prevalence of TR by age in men
26-29 40-49 50-59 60-69 70-83
No TR (%) 14.3 17.8 19 18.3 16.7
Trace (%) 72.7 72.5 71.5 59.8 47
Mild (%) 13 9.4 9.2 21.9 25.8
Moderate or severe (%) 0 0.3 0.3 0 1.5


Severity of TR Prevalence of TR by age in women
26-29 40-49 50-59 60-69 70-83
No TR (%) 20.5 16 14.5 10.4 14.1
Trace (%) 65.1 70 70.7 62.2 56.4
Mild (%) 13.2 13.5 14.1 25.7 23.9
Moderate or severe (%) 1.2 0.5 0.7 1.7 5.6

References

  1. 1.0 1.1 Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA; et al. (2014). "2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines". J Am Coll Cardiol. 63 (22): e57–185. doi:10.1016/j.jacc.2014.02.536. PMID pmid24603191 Check |pmid= value (help).
  2. 2.0 2.1 2.2 Singh JP, Evans JC, Levy D, Larson MG, Freed LA, Fuller DL; et al. (1999). "Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study)". Am J Cardiol. 83 (6): 897–902. PMID 10190406.
  3. Cohen SR, Sell JE, McIntosh CL, Clark RE (1987). "Tricuspid regurgitation in patients with acquired, chronic, pure mitral regurgitation. I. Prevalence, diagnosis, and comparison of preoperative clinical and hemodynamic features in patients with and without tricuspid regurgitation". J Thorac Cardiovasc Surg. 94 (4): 481–7. PMID 3657250.

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