Tetralogy of fallot causes: Difference between revisions
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{{CMG}}; '''Associate Editors-In-Chief:''' [[Priyamvada Singh| Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com], [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu]; '''Assistant Editor-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu] | {{CMG}}; '''Associate Editors-In-Chief:''' [[Priyamvada Singh| Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com], [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu]; '''Assistant Editor-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu] | ||
==Overview== | ==Overview== | ||
Both environmental and [[genetic]] factors appear to be involved in the development of tetralogy of Fallot. | |||
=== Both environmental and [[genetic]] factors appear to be involved in the development of tetralogy of Fallot. === | |||
==Causes== | ==Causes== | ||
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=== Common Causes === | === Common Causes === | ||
*[[Alcoholism]] in the mother | |||
*[[Diabetes]] | |||
*[[Pregnancy]] after the age of 40 | |||
*[[Rubella]] or other [[viral]] illnesses during pregnancy | |||
*[[Phenylketonuria]] ([[PKU]]) in the mother | |||
*[[Fetal hydantoin syndrome]] | |||
* Fetal carbamazepine syndrome | |||
=== Less Common Causes === | |||
* [[Clomifene]] | |||
* | * Poor nutrition during pregnancy | ||
* | |||
=== Genetic Causes === | |||
* There is a high [[incidence]] of [[chromosomal disorder]]s in children with tetralogy of Fallot.<ref>Marinho C, Alho I, Guerra A, Rego C, Areias J, Bicho M. The methylenetetrahydrofolate reductase gene variant (C677T) as a susceptibility gene for tetralogy of Fallot. Rev Port Cardiol. Jul-Aug 2009;28(7-8):809-12.</ref><ref>Lee CN, Su YN, Cheng WF, Lin MT, Wang JK, Wu MH, et al. Association of the C677T methylenetetrahydrofolate reductase mutation with congenital heart diseases. Acta Obstet Gynecol Scand. Dec 2005;84(12):1134-40.</ref> | |||
* Tetralogy of Fallot is associated with: | |||
**A gene polymorphism at the [[methylenetetrahydrofolate reductase]] ([[MTHFR]]) region has been associated with tetralogy of Fallot. | :*[[Down syndrome]] | ||
:*[[DiGeorge syndrome]] (a 22q11.2 deletion, a condition associated with heart defects, [[hypocalcemia]], and [[immune deficiency]]) A gene polymorphism at the [[methylenetetrahydrofolate reductase]] ([[MTHFR]]) region has been associated with tetralogy of Fallot. | |||
==References== | ==References== | ||
Revision as of 16:54, 11 February 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Priyamvada Singh, M.B.B.S. [2], Keri Shafer, M.D. [3]; Assistant Editor-In-Chief: Kristin Feeney, B.S. [4]
Overview
Both environmental and genetic factors appear to be involved in the development of tetralogy of Fallot.
Causes
Common Causes
- Alcoholism in the mother
- Diabetes
- Pregnancy after the age of 40
- Rubella or other viral illnesses during pregnancy
- Phenylketonuria (PKU) in the mother
- Fetal hydantoin syndrome
- Fetal carbamazepine syndrome
Less Common Causes
- Clomifene
- Poor nutrition during pregnancy
Genetic Causes
- There is a high incidence of chromosomal disorders in children with tetralogy of Fallot.[1][2]
- Tetralogy of Fallot is associated with:
- Down syndrome
- DiGeorge syndrome (a 22q11.2 deletion, a condition associated with heart defects, hypocalcemia, and immune deficiency) A gene polymorphism at the methylenetetrahydrofolate reductase (MTHFR) region has been associated with tetralogy of Fallot.
References
- ↑ Marinho C, Alho I, Guerra A, Rego C, Areias J, Bicho M. The methylenetetrahydrofolate reductase gene variant (C677T) as a susceptibility gene for tetralogy of Fallot. Rev Port Cardiol. Jul-Aug 2009;28(7-8):809-12.
- ↑ Lee CN, Su YN, Cheng WF, Lin MT, Wang JK, Wu MH, et al. Association of the C677T methylenetetrahydrofolate reductase mutation with congenital heart diseases. Acta Obstet Gynecol Scand. Dec 2005;84(12):1134-40.