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{{Syndrome of inappropriate antidiuretic hormone}}
{{Syndrome of inappropriate antidiuretic hormone}}
{{CMG}}; {{AE}}{{Vbe}}
{{CMG}}; {{AE}}{{Vbe}}


==Overview==
==Overview==
The lab findings which help in diagnosis of SIADH are serum electrolytes (especially sodium), creatinine, BUN, serum uric acid, serum cortisol, plasma ADH level. Urine osmolality,urine sodium level and GFR are also of diagnostic significance.
[[Laboratory]] findings which are helpful in diagnosing syndrome of inappropriate antidiuretic hormone (SIADH) include [[serum]] [[electrolytes]] (especially [[sodium]]), [[BUN|blood urea nitrogen (BUN)]], [[creatinine]], [[glucose]] levels, and [[osmolality]]. Laboratory findings in patients with SIADH may show [[hyponatremia]] ([[sodium]] <135 mEq/L) and low [[serum]] [[osmolality]] (< 280 mOsm/kg). Patients with SIADH have elevated [[urinary]] [[sodium]] level (> 20 mMol/L) and [[urine]] [[osmolality]] (generally > 100 mOsm/L). Patients with SIADH also have low [[BUN]], normal [[creatinine]], [[hypouricemia]], and [[hypoalbuminemia]].


==Laboratory Findings==
==Laboratory Findings==
Lab findings consistent with the diagnosis of SIADH are;
[[Laboratory]] findings consistent with the [[diagnosis]] of SIADH include:<ref name="pmid1245796">{{cite journal |vauthors=Shimamoto K, Murase T, Yamaji T |title=A heterologous radioimmunoassay for arginine vasopressin |journal=J. Lab. Clin. Med. |volume=87 |issue=2 |pages=338–44 |year=1976 |pmid=1245796 |doi= |url=}}</ref><ref name="pmid26069838">{{cite journal |vauthors=Laville M, Burst V, Peri A, Verbalis JG |title=Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH): therapeutic decision-making in real-life cases |journal=Clin Kidney J |volume=6 |issue=Suppl 1 |pages=i1–i20 |year=2013 |pmid=26069838 |pmc=4438352 |doi=10.1093/ckj/sft113 |url=}}</ref><ref name="pmid20935451">{{cite journal |vauthors=Peri A, Pirozzi N, Parenti G, Festuccia F, Menè P |title=Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) |journal=J. Endocrinol. Invest. |volume=33 |issue=9 |pages=671–82 |year=2010 |pmid=20935451 |doi=10.1007/BF03346668 |url=}}</ref><ref name="pmid20935451">{{cite journal |vauthors=Peri A, Pirozzi N, Parenti G, Festuccia F, Menè P |title=Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) |journal=J. Endocrinol. Invest. |volume=33 |issue=9 |pages=671–82 |year=2010 |pmid=20935451 |doi=10.1007/BF03346668 |url=}}</ref><ref name="pmid25657991">{{cite journal |vauthors=Oh JY, Shin JI |title=Syndrome of inappropriate antidiuretic hormone secretion and cerebral/renal salt wasting syndrome: similarities and differences |journal=Front Pediatr |volume=2 |issue= |pages=146 |year=2014 |pmid=25657991 |pmc=4302789 |doi=10.3389/fped.2014.00146 |url=}}</ref><ref name="pmid2350904">{{cite journal |vauthors=Maesaka JK, Batuman V, Yudd M, Salem M, Sved AF, Venkatesan J |title=Hyponatremia and hypouricemia: differentiation from SIADH |journal=Clin. Nephrol. |volume=33 |issue=4 |pages=174–8 |year=1990 |pmid=2350904 |doi= |url=}}</ref>
 
*[[Hyponatremia]] (< 135 mEq/l)
*Decreased serum sodium (<135 meq/l)
*[[Hypoosmolality]] (< 280 mOsm/kg)
*Decreased serum osmolality(<280mosm/kg)
*Low [[BUN]] levels
*Low BUN levels
*[[Hypoalbuminemia]]
*Low albumin levels
*[[Hypouricemia]]
*Low uric acid
*Normal [[creatinine]]
*Normal Creatinine
*Normal [[thyroid hormones]]
*Normal thyroid hormones
*Normal [[cortisol]]
*Normal cortisol
*Increased [[GFR]]
*Increased GFR
*Increased [[plasma]] [[ADH]] levels
*Increased plasma ADH levels<ref name="pmid1245796">{{cite journal |vauthors=Shimamoto K, Murase T, Yamaji T |title=A heterologous radioimmunoassay for arginine vasopressin |journal=J. Lab. Clin. Med. |volume=87 |issue=2 |pages=338–44 |year=1976 |pmid=1245796 |doi= |url=}}</ref>
 
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


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Latest revision as of 00:22, 30 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]

Overview

Laboratory findings which are helpful in diagnosing syndrome of inappropriate antidiuretic hormone (SIADH) include serum electrolytes (especially sodium), blood urea nitrogen (BUN), creatinine, glucose levels, and osmolality. Laboratory findings in patients with SIADH may show hyponatremia (sodium <135 mEq/L) and low serum osmolality (< 280 mOsm/kg). Patients with SIADH have elevated urinary sodium level (> 20 mMol/L) and urine osmolality (generally > 100 mOsm/L). Patients with SIADH also have low BUN, normal creatinine, hypouricemia, and hypoalbuminemia.

Laboratory Findings

Laboratory findings consistent with the diagnosis of SIADH include:[1][2][3][3][4][5]

References

  1. Shimamoto K, Murase T, Yamaji T (1976). "A heterologous radioimmunoassay for arginine vasopressin". J. Lab. Clin. Med. 87 (2): 338–44. PMID 1245796.
  2. Laville M, Burst V, Peri A, Verbalis JG (2013). "Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH): therapeutic decision-making in real-life cases". Clin Kidney J. 6 (Suppl 1): i1–i20. doi:10.1093/ckj/sft113. PMC 4438352. PMID 26069838.
  3. 3.0 3.1 Peri A, Pirozzi N, Parenti G, Festuccia F, Menè P (2010). "Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)". J. Endocrinol. Invest. 33 (9): 671–82. doi:10.1007/BF03346668. PMID 20935451.
  4. Oh JY, Shin JI (2014). "Syndrome of inappropriate antidiuretic hormone secretion and cerebral/renal salt wasting syndrome: similarities and differences". Front Pediatr. 2: 146. doi:10.3389/fped.2014.00146. PMC 4302789. PMID 25657991.
  5. Maesaka JK, Batuman V, Yudd M, Salem M, Sved AF, Venkatesan J (1990). "Hyponatremia and hypouricemia: differentiation from SIADH". Clin. Nephrol. 33 (4): 174–8. PMID 2350904.