Squamous cell carcinoma of the lung differential diagnosis: Difference between revisions

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==Overview==
==Overview==
Squamous cell carcinoma of the lung must be differentiated from other diseases that cause chronic cough, weight loss, hemoptysis, and dyspnea among adults such as [[pulmonary tuberculosis]], [[sarcoidosis]], pneumonia, pulmonary [[fungal infection]], and secondary metastases.<ref name="pmid24455507">{{cite journal| author=Bhatt M, Kant S, Bhaskar R| title=Pulmonary tuberculosis as differential diagnosis of lung cancer. | journal=South Asian J Cancer | year= 2012 | volume= 1 | issue= 1 | pages= 36-42 | pmid=24455507 | doi=10.4103/2278-330X.96507 | pmc=PMC3876596 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24455507  }} </ref><ref name="pmid22242302">{{cite journal| author=Kamiya K, Yoshizu A, Misumi Y, Hida N, Okamoto H, Yoshida S| title=[Lung abscess which needed to be distinguished from lung cancer; report of a case]. | journal=Kyobu Geka | year= 2011 | volume= 64 | issue= 13 | pages= 1204-7 | pmid=22242302 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22242302  }} </ref>
Squamous cell carcinoma of the lung must be differentiated from other diseases that cause chronic [[cough]], [[weight loss]], [[hemoptysis]], and [[dyspnea]] among adults such as [[pulmonary tuberculosis]], [[sarcoidosis]], pneumonia, pulmonary [[fungal infection]], and secondary metastases.<ref name="pmid24455507">{{cite journal| author=Bhatt M, Kant S, Bhaskar R| title=Pulmonary tuberculosis as differential diagnosis of lung cancer. | journal=South Asian J Cancer | year= 2012 | volume= 1 | issue= 1 | pages= 36-42 | pmid=24455507 | doi=10.4103/2278-330X.96507 | pmc=PMC3876596 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24455507  }} </ref><ref name="pmid22242302">{{cite journal| author=Kamiya K, Yoshizu A, Misumi Y, Hida N, Okamoto H, Yoshida S| title=[Lung abscess which needed to be distinguished from lung cancer; report of a case]. | journal=Kyobu Geka | year= 2011 | volume= 64 | issue= 13 | pages= 1204-7 | pmid=22242302 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22242302  }} </ref>


==Differential Diagnosis==
==Differential Diagnosis==
*The table below summarizes the findings that differentiate squamous cell carcinoma of the lung from other conditions that cause  chronic [[cough]], [[weight loss]], [[hemoptysis]], and [[dyspnea]].<ref name="pmid24455507">{{cite journal| author=Bhatt M, Kant S, Bhaskar R| title=Pulmonary tuberculosis as differential diagnosis of lung cancer. | journal=South Asian J Cancer | year= 2012 | volume= 1 | issue= 1 | pages= 36-42 | pmid=24455507 | doi=10.4103/2278-330X.96507 | pmc=PMC3876596 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24455507  }} </ref><ref name="pmid22242302">{{cite journal| author=Kamiya K, Yoshizu A, Misumi Y, Hida N, Okamoto H, Yoshida S| title=[Lung abscess which needed to be distinguished from lung cancer; report of a case]. | journal=Kyobu Geka | year= 2011 | volume= 64 | issue= 13 | pages= 1204-7 | pmid=22242302 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22242302  }} </ref>
*The table below summarizes the findings that differentiate squamous cell carcinoma of the lung from other conditions that cause  chronic [[cough]], [[weight loss]], [[hemoptysis]], and [[dyspnea]].<ref name="pmid24455507">{{cite journal| author=Bhatt M, Kant S, Bhaskar R| title=Pulmonary tuberculosis as differential diagnosis of lung cancer. | journal=South Asian J Cancer | year= 2012 | volume= 1 | issue= 1 | pages= 36-42 | pmid=24455507 | doi=10.4103/2278-330X.96507 | pmc=PMC3876596 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24455507  }} </ref><ref name="pmid22242302">{{cite journal| author=Kamiya K, Yoshizu A, Misumi Y, Hida N, Okamoto H, Yoshida S| title=[Lung abscess which needed to be distinguished from lung cancer; report of a case]. | journal=Kyobu Geka | year= 2011 | volume= 64 | issue= 13 | pages= 1204-7 | pmid=22242302 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22242302  }} </ref>


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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Differential Diagnosis}}
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Differential Diagnosis}}
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*Chronic [[cough]], [[weight loss]], [[hemoptysis]], nocturnal diaphoresis, [[dyspnea]]
*Chronic [[cough]], [[weight loss]], [[hemoptysis]], nocturnal diaphoresis, [[dyspnea]]
| style="padding: 5px 5px; background: #F5F5F5;" |   
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*In pulmonary tuberculosis, differentiating features include: increase in diameter despite optimal medical therapy, patients age is usually younger, hemoptisis is an early feature,  and CXR anatomical predilection for upper lobes
*In pulmonary tuberculosis, clinical features include: increase in diameter despite optimal medical therapy, patients age is usually younger, hemoptisis is an early feature,  and CXR anatomical predilection for upper lobes
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |''' [[Sarcoidosis]]'''
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |''' [[Sarcoidosis]]'''
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*Chronic [[cough]], [[weight loss]], and [[dyspnea]]
*Chronic [[cough]], [[weight loss]], and [[dyspnea]]
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| style="padding: 5px 5px; background: #F5F5F5;" |  
*In sarcoidosis, differentiating features include:  acute or subacute onset, CXR anatomical predilection for upper lobes,  and  usually resolve with antibiotic
*In sarcoidosis, clinical features include:  acute or subacute onset, CXR anatomical predilection for upper lobes,  and  usually resolve with antibiotic
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |'''[[Pneumonia]]'''
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |'''[[Pneumonia]]'''
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*Cough, fatigue, and dyspnea
*Cough, fatigue, and dyspnea
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*In pneumonia, differentiating features include: good response to antibiotics, acute onset, predilection on CXR is consolidation, laboratory markers indicate infection
*In pneumonia, clinical features include: good response to antibiotics, acute onset, predilection on CXR is consolidation, laboratory markers indicate infection
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" | '''[[Fungal infection|Pulmonary fungal infection]]'''
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" | '''[[Fungal infection|Pulmonary fungal infection]]'''
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*Chronic [[cough]], [[weight loss]], [[hemoptysis]], and [[dyspnea]]
*Chronic [[cough]], [[weight loss]], [[hemoptysis]], and [[dyspnea]]
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*In primary fungal infection, differentiating features include: CXR findings: air-cresecent sign, no response to antibioitcs, and  mimcs tuberculosis
*In primary fungal infection, clinical features include: CXR findings: air-cresecent sign, no response to antibioitcs, and  mimcs tuberculosis
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |'''[[Metastases]]'''
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |'''[[Metastases]]'''
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*Chronic [[cough]], [[weight loss]], [[hemoptysis]], and [[dyspnea]]
*Chronic [[cough]], [[weight loss]], [[hemoptysis]], and [[dyspnea]]
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*In metastases, differentiating features include: multicentricity, involvement of the contralateral hemitorax, and usually primary cancer is known
*In metastases, clinical features include: multicentricity, involvement of the contralateral hemitorax, and usually the location of the primary cancer is known
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Revision as of 19:09, 25 April 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2] Maria Fernanda Villarreal, M.D. [3]

Overview

Squamous cell carcinoma of the lung must be differentiated from other diseases that cause chronic cough, weight loss, hemoptysis, and dyspnea among adults such as pulmonary tuberculosis, sarcoidosis, pneumonia, pulmonary fungal infection, and secondary metastases.[1][2]

Differential Diagnosis
Differential Diagnosis Similar Features Differentiating Features
Pulmonary tuberculosis
  • In pulmonary tuberculosis, clinical features include: increase in diameter despite optimal medical therapy, patients age is usually younger, hemoptisis is an early feature, and CXR anatomical predilection for upper lobes
Sarcoidosis
  • In sarcoidosis, clinical features include: acute or subacute onset, CXR anatomical predilection for upper lobes, and usually resolve with antibiotic
Pneumonia
  • Cough, fatigue, and dyspnea
  • In pneumonia, clinical features include: good response to antibiotics, acute onset, predilection on CXR is consolidation, laboratory markers indicate infection
Pulmonary fungal infection
  • In primary fungal infection, clinical features include: CXR findings: air-cresecent sign, no response to antibioitcs, and mimcs tuberculosis
Metastases
  • In metastases, clinical features include: multicentricity, involvement of the contralateral hemitorax, and usually the location of the primary cancer is known

References

  1. ↑ 1.0 1.1 Bhatt M, Kant S, Bhaskar R (2012). "Pulmonary tuberculosis as differential diagnosis of lung cancer". South Asian J Cancer. 1 (1): 36–42. doi:10.4103/2278-330X.96507. PMC 3876596. PMID 24455507.
  2. ↑ 2.0 2.1 Kamiya K, Yoshizu A, Misumi Y, Hida N, Okamoto H, Yoshida S (2011). "[Lung abscess which needed to be distinguished from lung cancer; report of a case]". Kyobu Geka. 64 (13): 1204–7. PMID 22242302.


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