RhoH

Ras homolog gene family, member H
Identifiers
Symbols	RHOH ; ARHH; TTF
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3180
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RHOH 204951 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

RhoH (Ras homolog gene family, member H) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOH.

Gene

Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. Unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells. }}

Further reading

• Dallery E, Galiègue-Zouitina S, Collyn-d'Hooghe M; et al. (1995). "TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation". Oncogene. 10 (11): 2171–8. PMID 7784061.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dallery-Prudhomme E, Roumier C, Denis C; et al. (1997). "Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization". Genomics. 43 (1): 89–94. doi:10.1006/geno.1997.4788. PMID 9226377.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yousefi S, Cooper PR, Mueck B; et al. (2000). "cDNA representational difference analysis of human neutrophils stimulated by GM-CSF". Biochem. Biophys. Res. Commun. 277 (2): 401–9. doi:10.1006/bbrc.2000.3678. PMID 11032736.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fauré J, Dagher MC (2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie. 83 (5): 409–14. PMID 11368848.
• Li X, Bu X, Lu B; et al. (2002). "The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function". Mol. Cell. Biol. 22 (4): 1158–71. PMID 11809807.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lahousse S, Smorowski AL, Denis C; et al. (2005). "Structural features of hematopoiesis-specific RhoH/ARHH gene: high diversity of 5'-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation". Gene. 343 (1): 55–68. doi:10.1016/j.gene.2004.08.022. PMID 15563831.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lopez-Ilasaca MA, Bernabe-Ortiz JC, Na SY; et al. (2005). "Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells". FEBS Lett. 579 (3): 648–54. doi:10.1016/j.febslet.2004.12.039. PMID 15670823.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barrios-Rodiles M, Brown KR, Ozdamar B; et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reiniger L, Bödör C, Bognár A; et al. (2006). "Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation". Leukemia. 20 (6): 1089–95. doi:10.1038/sj.leu.2404183. PMID 16541139.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hiraga J, Katsumi A, Iwasaki T; et al. (2007). "Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma". Leukemia. 21 (8): 1846–7. doi:10.1038/sj.leu.2404717. PMID 17443219.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Traverse-Glehen A, Verney A, Baseggio L; et al. (2007). "Analysis of BCL-6, CD95, PIM1, RHO/TTF and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin". Leukemia. 21 (8): 1821–4. doi:10.1038/sj.leu.2404706. PMID 17476282.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)