Renal artery stenosis resident survival guide

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Karol Gema Hernandez, M.D. [2]

Definition

Renal artery stenosis is defined as a dimished diameter of the lumen of the renal artery. Renal artery of >70% is considered hemodynamically significant.[1]

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. Renal artery stenosis does not have life threatening causes.

Common Causes

Managment of RAS

Clinical Clues to the Diagnosis of RAS

 
 
 
Determine if one or more of the following is present:
❑ Onset of hypertension before the age of 30 years
❑ Onset of severe hypertension after the age of 55
❑ Accelerated, resistant, or malignant hypertension
❑ Development of new azotemia or worsening renal function after administration of an ACE inhibitor or ARB agent
❑ Unexplained atrophic kidney or size discrepancy between kidneys >1.5 cm
❑ Sudden, unexplained pulmonary edema
❑ Unexplained renal dysfunction, including individuals starting renal replacement therapy
❑ Multi-vessel CAD
❑ Unexplained CHF
❑ Refractory angina
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
If yes:
❑ Proceed with non-invasive imaging [2]
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Is patient allergic to contrast
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
If yes:
❑ Proceed with US
 
If no check for:
❑ Implanted devices:
- Pacemakers
- Defibrillators
- Cochlear implants
- Spinal cord stimulators
❑ Claustrophobic patient
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
If none of the above proceed with MRA
 
If yes to any of the above, proceed with CT
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Inconclusive noninvasive test but with high clinical index of suspicion:
❑ Perform catheter angiography
 
Confirmed RAS: ❑Proceed to treatment
 
 
 
 
 

Algorithm based on the 2013 AHA Guidelines Recommendations for Management of Patients with PAD.[1]

Treatment

 
 
 
 
 
 
 
Initiate a regimen that combines:[3]
❑ Tight blood pressure control to <130/80 mmHg (120/75 mmHg if proteinuria is present) with:
❑ Control of hyperlipidemia (LDL cholesterol <70 mg/dl) with statins
❑ Glycemic control (Hemoglobin A1c <7%)
Antiplatelet agents
❑ Life style modifications:
  • Smoking cessation counseling
  • Normalization of body weight
  •  
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Proceed to evaluate clinical indications for revascularization:
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    ❑ RAS with:

    - Accelerated, resistant, or malignant hypertension
    - Hypertension with an unexplained unilateral small kidney

    - Hypertension with medication intolerance
    ❑ Progressive CKD with bilateral RAS or RAS to a solitary functioning kidney
    ❑ Hemodynamically significant RAS with recurrent, unexplainedCHF or sudden, unexplained pulmonary edema
    ❑ Unstable angina
    ❑ Asymptomatic bilateral or solitary viable kidney
    CRI with unilateral RAS
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    If any of the above:
    ❑ Percutaneous revascularization
     
     
     
    If:
    ❑ Fibromuscular dysplastic that extends into segmental arteries
    ❑ Macroaneurysms
    ❑ atherosclerotic RAS with multiple small renal arteries or early primary branching of the main renal artery
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Fibromuscular dysplasia RAS
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Renal stent placement is indicated for ostial atherosclerotic RAS lesions that meet the clinical criteria for intervention
     
     
     
    Balloon angioplasty with bailout stent placement if necessary is recommended for fibromuscular dysplasia lesions
     


    Algorithm based on the 2013 AHA Guidelines Recommendations for Management of Patients with PAD.[1] [4]

    References

    1. 1.0 1.1 1.2 Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH; et al. (2013). "Management of patients with peripheral artery disease (compilation of 2005 and 2011 ACCF/AHA guideline recommendations): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines". Circulation. 127 (13): 1425–43. doi:10.1161/CIR.0b013e31828b82aa. PMID 23457117.
    2. Lao D, Parasher PS, Cho KC, Yeghiazarians Y (2011). "Atherosclerotic renal artery stenosis--diagnosis and treatment". Mayo Clin Proc. 86 (7): 649–57. doi:10.4065/mcp.2011.0181. PMC 3127560. PMID 21719621‎ Check |pmid= value (help).
    3. Annigeri RA (2012). "Medical therapy is best for atherosclerotic renal artery stenosis: Arguments for". Indian J Nephrol. 22 (1): 1–4. doi:10.4103/0971-4065.91177. PMC 3263056. PMID 22279335.
    4. Haller C (2002). "Arteriosclerotic renal artery stenosis: conservative versus interventional management". Heart. 88 (2): 193–7. PMC 1767237. PMID 12117859.


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