Primary biliary cirrhosis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]

Overview

The cause of primary biliary cirrhosis has not been identified. However, it is thought that hyper-functioning immune system attributed to genetic predisposition is thought to have a role in causing primary biliary cirrhosis. Few environmental factors such as cigarette smoking, infections and chemical exposure have also known to play a role in causing primary biliary cirrhosis.

Causes

  • The cause of primary biliary cirrhosis has not been identified. However, it is thought that hyper-functioning immune system attributed to genetic predisposition is thought to have a role in causing primary biliary cirrhosis.[1][2][3]
  • Few environmental factors such as cigarette smoking, infections and chemical exposure have also known to play a role in causing primary biliary cirrhosis.[1][2][3]
  • To learn more about the risk factors for the development of primary biliary cirrhosis, click here.

References

  1. 1.0 1.1 Carey EJ, Ali AH, Lindor KD (2015). "Primary biliary cirrhosis". Lancet. 386 (10003): 1565–75. doi:10.1016/S0140-6736(15)00154-3. PMID 26364546.
  2. 2.0 2.1 Selmi C, Bowlus CL, Gershwin ME, Coppel RL (2011). "Primary biliary cirrhosis". Lancet. 377 (9777): 1600–9. doi:10.1016/S0140-6736(10)61965-4. PMID 21529926.
  3. 3.0 3.1 Juran BD, Lazaridis KN (2014). "Environmental factors in primary biliary cirrhosis". Semin Liver Dis. 34 (3): 265–72. doi:10.1055/s-0034-1383726. PMC 4232304. PMID 25057950.

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