Primary biliary cirrhosis epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S[2]

Overview

The prevalence of primary biliary cirrhosis is approximately 19 to 402 cases per 100,000 individuals worldwide. Primary biliary cirrhosis commonly affects individuals in their 40s or 50s. There is no racial predilection to primary biliary cirrhosis. Females are more commonly affected by primary biliary cirrhosis than males. The majority of primary biliary cirrhosis cases are reported in northern Europe and North America (particularly in Scandinavia, Great Britain, and the northern midwest regions of the United States).

Epidemiology and Demographics

Prevalence

  • The prevalence of primary biliary cirrhosis is approximately 19 to 402 cases per 100,000 individuals worldwide.[1][2]

Age

  • Primary biliary cirrhosis commonly affects individuals in their 40s or 50s.[3][4]

Race

  • There is no racial predilection to primary biliary cirrhosis.

Gender

  • Females are more commonly affected by primary biliary cirrhosis than males.[5]

Region

  • The majority of primary biliary cirrhosis cases are reported in northern Europe and North America (particularly in Scandinavia, Great Britain, and the northern midwest regions of the United States).[6]

References

  1. Kim WR, Lindor KD, Locke GR, Therneau TM, Homburger HA, Batts KP; et al. (2000). "Epidemiology and natural history of primary biliary cirrhosis in a US community". Gastroenterology. 119 (6): 1631–6. PMID 11113084.
  2. Sood S, Gow PJ, Christie JM, Angus PW (2004). "Epidemiology of primary biliary cirrhosis in Victoria, Australia: high prevalence in migrant populations". Gastroenterology. 127 (2): 470–5. PMID 15300579.
  3. Kaplan MM, Gershwin ME (2005). "Primary biliary cirrhosis". N Engl J Med. 353 (12): 1261–73. doi:10.1056/NEJMra043898. PMID 16177252.
  4. Dahlan Y, Smith L, Simmonds D, Jewell LD, Wanless I, Heathcote EJ; et al. (2003). "Pediatric-onset primary biliary cirrhosis". Gastroenterology. 125 (5): 1476–9. PMID 14598264.
  5. Lleo A, Battezzati PM, Selmi C, Gershwin ME, Podda M (2008). "Is autoimmunity a matter of sex?". Autoimmun Rev. 7 (8): 626–30. doi:10.1016/j.autrev.2008.06.009. PMID 18603021.
  6. Selmi C, Bowlus CL, Gershwin ME, Coppel RL (2011). "Primary biliary cirrhosis". Lancet. 377 (9777): 1600–9. doi:10.1016/S0140-6736(10)61965-4. PMID 21529926.

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