Primary biliary cirrhosis screening

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S[2]

Overview

There is insufficient evidence to recommend routine screening for primary biliary cirrhosis. However, patients with PBC having elevated alpha feto protein and male sex, more frequent screening for surveillance of hepatocellular carcinoma is recommended.

Screening

  • There is insufficient evidence to recommend routine screening for primary biliary cirrhosis.
  • However, patients with primary biliary cirrhosis having elevated alpha feto protein and male sex, more frequent screening for surveillance of hepatocellular carcinoma is recommended. [1][2]

References

  1. Jones DE, Metcalf JV, Collier JD, Bassendine MF, James OF (1997). "Hepatocellular carcinoma in primary biliary cirrhosis and its impact on outcomes". Hepatology. 26 (5): 1138–42. doi:10.1002/hep.510260508. PMID 9362353.
  2. Silveira MG, Suzuki A, Lindor KD (2008). "Surveillance for hepatocellular carcinoma in patients with primary biliary cirrhosis". Hepatology. 48 (4): 1149–56. doi:10.1002/hep.22458. PMID 18785621.

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