Peripheral neuropathy differential diagnosis: Difference between revisions

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* Lower motor neuron signs and symptoms in peripheral neuropathy typically present with [[Diminished stature|diminished]] [[Deep tendon reflex|deep tendon reflexes]], [[flaccid paralysis]], severe [[muscle atrophy]], negative [[babinski reflex]] and[[fasciculation]] whereas upper motor neuron signs and symptoms in brain and [[spinal cord]] lesions typically present with [[Hyperactive reflexes|hyperactive]] [[Deep tendon reflex|deep tendon reflexes]], [[spastic paralysis]], no [[muscle atrophy]], positive [[babinski reflex]] and no [[fasciculation]].
* Lower motor neuron signs and symptoms in peripheral neuropathy typically present with [[Diminished stature|diminished]] [[Deep tendon reflex|deep tendon reflexes]], [[flaccid paralysis]], severe [[muscle atrophy]], negative [[babinski reflex]] and[[fasciculation]] whereas upper motor neuron signs and symptoms in brain and [[spinal cord]] lesions typically present with [[Hyperactive reflexes|hyperactive]] [[Deep tendon reflex|deep tendon reflexes]], [[spastic paralysis]], no [[muscle atrophy]], positive [[babinski reflex]] and no [[fasciculation]].
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! rowspan="4"  style="background: #4479BA; color: #FFFFFF; text-align: center;|Diseases
| colspan="6" rowspan="1"  style="background: #4479BA; color: #FFFFFF; text-align: center;|'''Clinical manifestations'''
! colspan="7" rowspan="2"  style="background: #4479BA; color: #FFFFFF; text-align: center;|Para-clinical findings
| colspan="1" rowspan="4"  style="background: #4479BA; color: #FFFFFF; text-align: center;|'''Gold standard'''
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;|Additional findings
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| colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;|'''Symptoms'''
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! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;|Histopathology
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! style="background: #4479BA; color: #FFFFFF; text-align: center;|Symptom 1
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;|Symptom 2
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Symptom 3
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Physical exam 1
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;|Physical exam 2
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Physical exam 3
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Lab 1
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Lab 2
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Lab 3
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Imaging 1
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!Diseases
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! colspan="1" rowspan="1" |Symptom 2
!Symptom 3
!Physical exam 1
! colspan="1" rowspan="1" |Physical exam 2
!Physical exam 3
!Lab 1
!Lab 2
!Lab 3
!Imaging 1
!Imaging 2
!Imaging 3
!Histopathology
|'''Gold standard'''
!Additional findings
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Revision as of 16:50, 6 September 2018

Peripheral neuropathy Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

Peripheral neuropathy must be differentiated from other diseases that cause , sensorineural, motor, autonomic and balance problems, such as spinal cord lesions and brain lesions. Peripheral neuropathy usually causes lower motor nerve damage, while lesions in brain and spinal cord usually cause lower motor neuron damage. The difference between upper and lower motor neuron symptoms and signs may be very helpful to differentiate peripheral neuropathy from brain and spinal cord lesions. Lower motor neuron signs and symptoms in peripheral neuropathy typically present with diminished deep tendon reflexes, flaccid paralysis, severe muscle atrophy, negative babinski reflex andfasciculation whereas upper motor neuron signs and symptoms in brain and spinal cord lesions typically present with hyperactive deep tendon reflexes, spastic paralysis, no muscle atrophy, positive babinski reflex and no fasciculation.

Differentiating peripheral neuropathy from other diseases

Diseases Clinical manifestations Para-clinical findings Gold standard Additional findings
Symptoms Physical examination
Lab Findings Imaging Histopathology
Symptom 1 Symptom 2 Symptom 3 Physical exam 1 Physical exam 2 Physical exam 3 Lab 1 Lab 2 Lab 3 Imaging 1 Imaging 2 Imaging 3
Differential Diagnosis 1
Differential Diagnosis 2
Differential Diagnosis 3
Diseases Symptom 1 Symptom 2 Symptom 3 Physical exam 1 Physical exam 2 Physical exam 3 Lab 1 Lab 2 Lab 3 Imaging 1 Imaging 2 Imaging 3 Histopathology Gold standard Additional findings
Differential Diagnosis 4
Differential Diagnosis 5
Differential Diagnosis 6


Diseases Clinical manifestations Additional findings
Physical examination
Deep tendon reflexes Type of paralysis Muscular atrophy
Peripheral neuropathy Diminished Flaccid paralysis Severe muscle atrophy Negative babinski reflex, fasciculation
Brain lesion and most spinal cord lesions Hyperactive Spastic paralysis No muscle atrophy Positive babinski reflex, no fasciculation

References

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