Peripheral neuropathy epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

The prevalence of the peripheral neuropathy is approximately 2400 per 100,000 to 7000 per 100,000 individuals depending on the region. The case-fatality rate of the peripheral neuropathy is very low. Patients of all age groups may develop peripheral neuropathy. The incidence of peripheral neuropathy increases with age. Peripheral neuropathy affects men more then women. The males develop neuropathy earlier than the females.

Epidemiology and Demographics

Prevalence

  • The prevalence of the peripheral neuropathy is approximately 2400 per 100,000 to 7000 per 100,000 individuals depending on the region.[1]
  • Diabetic neuropathy affects approximately 206 million people worldwide and was identified in 2021 as the fifth most common neurological cause of disability according to the Global Burden of Disease study. [2]

Case-fatality rate/Mortality rate

  • The case-fatality rate of the peripheral neuropathy is very low.

Age

  • Patients of all age groups may develop peripheral neuropathy.[1]
  • The prevalence of peripheral neuropathy increases with age and is estimated to affect 6% to 10% of individuals older than 60 years.[3],[4]

Gender

  • Peripheral neuropathy affects men more then women.[5]
  • The males develop neuropathy earlier than the females.[6]

References

  1. 1.0 1.1 Martyn CN, Hughes RA (1997). "Epidemiology of peripheral neuropathy". J Neurol Neurosurg Psychiatry. 62 (4): 310–8. PMC 1074084. PMID 9120441.
  2. "Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021". Lancet Neurol. 23 (4): 344–381. April 2024. doi:10.1016/S1474-4422(24)00038-3. PMID 38493795 Check |pmid= value (help).
  3. Hanewinckel R, van Oijen M, Ikram MA, van Doorn PA (January 2016). "The epidemiology and risk factors of chronic polyneuropathy". Eur J Epidemiol. 31 (1): 5–20. doi:10.1007/s10654-015-0094-6. PMID 26700499.
  4. Hoffman EM, Staff NP, Robb JM, St Sauver JL, Dyck PJ, Klein CJ (April 2015). "Impairments and comorbidities of polyneuropathy revealed by population-based analyses". Neurology. 84 (16): 1644–51. doi:10.1212/WNL.0000000000001492. PMC 4409579. PMID 25832668.
  5. Cheng YJ, Gregg EW, Kahn HS, Williams DE, De Rekeneire N, Narayan KM (2006). "Peripheral insensate neuropathy--a tall problem for US adults?". Am J Epidemiol. 164 (9): 873–80. doi:10.1093/aje/kwj281. PMID 16905646.
  6. Mehta SA, Ahmed A, Laverty M, Holzman RS, Valentine F, Sivapalasingam S (2011). "Sex differences in the incidence of peripheral neuropathy among Kenyans initiating antiretroviral therapy". Clin Infect Dis. 53 (5): 490–6. doi:10.1093/cid/cir432. PMC 3156141. PMID 21844033.

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