PROX1
| Prospero-related homeobox 1 | |||||
|---|---|---|---|---|---|
| Identifiers | |||||
| Symbols | PROX1 ; | ||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 2069 | ||||
| |||||
| RNA expression pattern | |||||
| File:PBB GE PROX1 207401 at tn.png | |||||
| More reference expression data | |||||
| Orthologs | |||||
| Template:GNF Ortholog box | |||||
| Species | Human | Mouse | |||
| Entrez | n/a | n/a | |||
| Ensembl | n/a | n/a | |||
| UniProt | n/a | n/a | |||
| RefSeq (mRNA) | n/a | n/a | |||
| RefSeq (protein) | n/a | n/a | |||
| Location (UCSC) | n/a | n/a | |||
| PubMed search | n/a | n/a | |||
Prospero-related homeobox 1, also known as PROX1, is a human gene.[1]
References
Further reading
- Zinovieva RD, Duncan MK, Johnson TR; et al. (1996). "Structure and chromosomal localization of the human homeobox gene Prox 1". Genomics. 35 (3): 517–22. doi:10.1006/geno.1996.0392. PMID 8812486.
- Wigle JT, Chowdhury K, Gruss P, Oliver G (1999). "Prox1 function is crucial for mouse lens-fibre elongation". Nat. Genet. 21 (3): 318–22. doi:10.1038/6844. PMID 10080188.
- Mouta Carreira C, Nasser SM, di Tomaso E; et al. (2001). "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis". Cancer Res. 61 (22): 8079–84. PMID 11719431.
- Rodriguez-Niedenführ M, Papoutsi M, Christ B; et al. (2002). "Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts". Anat. Embryol. 204 (5): 399–406. PMID 11789987.
- Duncan MK, Cui W, Oh DJ, Tomarev SI (2002). "Prox1 is differentially localized during lens development". Mech. Dev. 112 (1–2): 195–8. PMID 11850194.
- Chen Q, Dowhan DH, Liang D; et al. (2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. PMID 11943779.
- Wilting J, Papoutsi M, Christ B; et al. (2002). "The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues". FASEB J. 16 (10): 1271–3. doi:10.1096/fj.01-1010fje. PMID 12060670.
- Petrova TV, Mäkinen T, Mäkelä TP; et al. (2002). "Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor". EMBO J. 21 (17): 4593–9. PMID 12198161.
- Hong YK, Harvey N, Noh YH; et al. (2003). "Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate". Dev. Dyn. 225 (3): 351–7. doi:10.1002/dvdy.10163. PMID 12412020.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Dyer MA, Livesey FJ, Cepko CL, Oliver G (2003). "Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina". Nat. Genet. 34 (1): 53–8. doi:10.1038/ng1144. PMID 12692551.
- Nagai H, Li Y, Hatano S; et al. (2003). "Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies". Genes Chromosomes Cancer. 38 (1): 13–21. doi:10.1002/gcc.10248. PMID 12874782.
- Steffensen KR, Holter E, Båvner A; et al. (2005). "Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue". EMBO Rep. 5 (6): 613–9. doi:10.1038/sj.embor.7400147. PMID 15143342.
- Qin J, Gao DM, Jiang QF; et al. (2005). "Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene". Mol. Endocrinol. 18 (10): 2424–39. doi:10.1210/me.2004-0009. PMID 15205472.
- Dudas J, Papoutsi M, Hecht M; et al. (2005). "The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium". Anat. Embryol. 208 (5): 359–66. doi:10.1007/s00429-004-0403-4. PMID 15232737.
- Reis RM, Reis-Filho JS, Longatto Filho A; et al. (2006). "Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors". Pathol. Res. Pract. 201 (12): 771–6. doi:10.1016/j.prp.2005.08.010. PMID 16308102.
- Song KH, Li T, Chiang JY (2006). "A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene". J. Biol. Chem. 281 (15): 10081–8. doi:10.1074/jbc.M513420200. PMID 16488887.
- Schneider M, Büchler P, Giese N; et al. (2006). "Role of lymphangiogenesis and lymphangiogenic factors during pancreatic cancer progression and lymphatic spread". Int. J. Oncol. 28 (4): 883–90. PMID 16525637.
- Shimoda M, Takahashi M, Yoshimoto T; et al. (2006). "A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma". Clin. Cancer Res. 12 (20 Pt 1): 6005–11. doi:10.1158/1078-0432.CCR-06-0712. PMID 17062673.
- Laerm A, Helmbold P, Goldberg M; et al. (2007). "Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system". J. Hepatol. 46 (1): 89–97. doi:10.1016/j.jhep.2006.07.033. PMID 17069925.
External links
- PROX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.