PROX1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene.[1][2]


Interactions

PROX1 has been shown to interact with EP300.[3]

Production

PROX1 is produced primarily in the dentate gyrus in the mouse, and in the dentate gyrus and white matter in humans. Gene expression data for mouse, human and macaque from the Allen Brain Atlases can be found here.

Clinical significance

PROX1 is used as a marker for lymphatic endothelium in biopsy samples.

References

  1. Zinovieva RD, Duncan MK, Johnson TR, Torres R, Polymeropoulos MH, Tomarev SI (Dec 1996). "Structure and chromosomal localization of the human homeobox gene Prox 1" (PDF). Genomics. 35 (3): 517–22. doi:10.1006/geno.1996.0392. PMID 8812486.
  2. "Entrez Gene: PROX1 prospero-related homeobox 1".
  3. Chen, Qin; Dowhan Dennis H; Liang Dongcai; Moore David D; Overbeek Paul A (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. United States. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. ISSN 0021-9258. PMID 11943779.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.