Osteonectin

Secreted protein, acidic, cysteine-rich (osteonectin)
File:PBB Protein SPARC image.jpg PDB rendering based on 1bmo.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1bmo​, 1nub​, 1sra​
Identifiers
Symbols	SPARC ; ON
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31132
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SPARC 200665 s at tn.png
File:PBB GE SPARC 212667 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Osteonectin is a glycoprotein in the bone that binds calcium. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone mineral calcium. Some current research shows a correlation between osteonectin over expression and ampullary cancers and chronic pancreatitis.

External links

• Osteonectin at the US National Library of Medicine Medical Subject Headings (MeSH)

Further reading

• Yan Q, Sage EH (1999). "SPARC, a matricellular glycoprotein with important biological functions". J. Histochem. Cytochem. 47 (12): 1495–506. PMID 10567433.
• Altura BM (1975). "Pharmacological effects of alpha-methyldopa, alpha-methylnorepinephrine, and octopamine on rat arteriolar, arterial, and terminal vascular smooth". Circ. Res. 36 (6 Suppl 1): 233–40. PMID 1093755.
• Raines EW, Lane TF, Iruela-Arispe ML; et al. (1992). "The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1281–5. PMID 1311092.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mundlos S, Schwahn B, Reichert T, Zabel B (1992). "Distribution of osteonectin mRNA and protein during human embryonic and fetal development". J. Histochem. Cytochem. 40 (2): 283–91. PMID 1552170.CS1 maint: Multiple names: authors list (link)
• Kelm RJ, Mann KG (1990). "Human platelet osteonectin: release, surface expression, and partial characterization". Blood. 75 (5): 1105–13. PMID 2306517.
• Young MF, Day AA, Dominquez P; et al. (1990). "Structure and expression of osteonectin mRNA in human tissue". Connect. Tissue Res. 24 (1): 17–28. PMID 2338025.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Metsäranta M, Young MF, Sandberg M; et al. (1989). "Localization of osteonectin expression in human fetal skeletal tissues by in situ hybridization". Calcif. Tissue Int. 45 (3): 146–52. PMID 2505905.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sage H, Vernon RB, Funk SE; et al. (1989). "SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix". J. Cell Biol. 109 (1): 341–56. PMID 2745554.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Villarreal XC, Mann KG, Long GL (1989). "Structure of human osteonectin based upon analysis of cDNA and genomic sequences". Biochemistry. 28 (15): 6483–91. PMID 2790009.CS1 maint: Multiple names: authors list (link)
• Swaroop A, Hogan BL, Francke U (1988). "Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33". Genomics. 2 (1): 37–47. PMID 2838412.CS1 maint: Multiple names: authors list (link)
• Wewer UM, Albrechtsen R, Fisher LW; et al. (1988). "Osteonectin/SPARC/BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane". Am. J. Pathol. 132 (2): 345–55. PMID 3400777.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clezardin P, Malaval L, Ehrensperger AS; et al. (1988). "Complex formation of human thrombospondin with osteonectin". Eur. J. Biochem. 175 (2): 275–84. PMID 3402455.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lankat-Buttgereit B, Mann K, Deutzmann R; et al. (1988). "Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin)". FEBS Lett. 236 (2): 352–6. PMID 3410046.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stenner DD, Tracy RP, Riggs BL, Mann KG (1986). "Human platelets contain and secrete osteonectin, a major protein of mineralized bone". Proc. Natl. Acad. Sci. U.S.A. 83 (18): 6892–6. PMID 3489235.CS1 maint: Multiple names: authors list (link)
• Jundt G, Berghäuser KH, Termine JD, Schulz A (1987). "Osteonectin--a differentiation marker of bone cells". Cell Tissue Res. 248 (2): 409–15. PMID 3581152.CS1 maint: Multiple names: authors list (link)
• Fisher LW, Hawkins GR, Tuross N, Termine JD (1987). "Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone". J. Biol. Chem. 262 (20): 9702–8. PMID 3597437.CS1 maint: Multiple names: authors list (link)
• Sage H, Johnson C, Bornstein P (1984). "Characterization of a novel serum albumin-binding glycoprotein secreted by endothelial cells in culture". J. Biol. Chem. 259 (6): 3993–4007. PMID 6368555.CS1 maint: Multiple names: authors list (link)
• Termine JD, Kleinman HK, Whitson SW; et al. (1982). "Osteonectin, a bone-specific protein linking mineral to collagen". Cell. 26 (1 Pt 1): 99–105. PMID 7034958.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xie RL, Long GL (1995). "Role of N-linked glycosylation in human osteonectin. Effect of carbohydrate removal by N-glycanase and site-directed mutagenesis on structure and binding of type V collagen". J. Biol. Chem. 270 (39): 23212–7. PMID 7559469.
• Maurer P, Hohenadl C, Hohenester E; et al. (1995). "The C-terminal portion of BM-40 (SPARC/osteonectin) is an autonomously folding and crystallisable domain that binds calcium and collagen IV". J. Mol. Biol. 253 (2): 347–57. doi:10.1006/jmbi.1995.0557. PMID 7563094.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)