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Revision as of 02:56, 27 November 2017

Nasopharyngeal carcinoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]

Overview

On microscopic histopathological analysis, abundant dense eosinophilic cytoplasm and prominent lymphoid component are characteristic findings of nasopharyngeal carcinoma.

Pathophysiology

Genetics

Genes involved in the pathogenesis of nasopharyngeal carcinoma include:

Pathology

Gross Pathology

  • Nasal cavity involvement - common in early disease[1]

Microscopic Pathology

Features:[2]

  • Prominent lymphoid component (Lymphoepithelioma) - key feature
  • Features of squamous cell carcinoma:
    • Cohesive cells with:
      • Abundant dense eosinophilic cytoplasm
      • Central nuclei +/- small/indistinct nucleoli
Nasopharyngeal carcinoma


Nasopharyngeal carcinoma may be classified according to microscopic features into 3 subtypes:[3]

  • Well-differentiated (keratinizing type)
  • Moderately-differentiated (nonkeratinizing type)
  • Undifferentiated (most strongly associated with Epstein-Barr virus infection)

Immunohistochemistry

Immunohistochemistry stains for nasopharyngeal carcinoma include:

  • EBER positive
  • p16 negative[4]

References

  1. Abdel Khalek Abdel Razek, A.; King, A. (2012). "MRI and CT of nasopharyngeal carcinoma". AJR Am J Roentgenol. 198 (1): 11–8. doi:10.2214/AJR.11.6954. PMID 22194474. Unknown parameter |month= ignored (help)
  2. Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma
  3. Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.
  4. Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J (1998). "Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product". Am. J. Pathol. 152 (4): 865–9. PMC 1858242. PMID 9546345. Unknown parameter |month= ignored (help)

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