Multiple endocrine neoplasia type 2 classification: Difference between revisions
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{{Multiple endocrine neoplasia type 2}} | {{Multiple endocrine neoplasia type 2}} | ||
{{CMG}}; {{AE}} {{Ammu}} | {{CMG}}; {{AE}} {{Ammu}} {{S.G.}} | ||
==Overview== | ==Overview== | ||
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==Classification== | ==Classification== | ||
Multiple endocrine neoplasia type 2 (MEN2) can be further divided into three subtypes: type 2A, type 2B, and familial medullary thyroid carcinoma (FMTC). | Multiple endocrine neoplasia type 2 (MEN2) can be further divided into three subtypes: type 2A, type 2B, and familial medullary thyroid carcinoma (FMTC).<ref name="pmid25810047">{{cite journal| author=Wells SA, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF et al.| title=Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. | journal=Thyroid | year= 2015 | volume= 25 | issue= 6 | pages= 567-610 | pmid=25810047 | doi=10.1089/thy.2014.0335 | pmc=PMC4490627 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25810047 }} </ref><ref name="Hansford2000">{{cite journal|last1=Hansford|first1=J. R|title=Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesis|journal=Journal of Medical Genetics|volume=37|issue=11|year=2000|pages=817–827|issn=14686244|doi=10.1136/jmg.37.11.817}}</ref> | ||
* These subtypes differ in their characteristic signs and symptoms and risk of specific [[tumor]]s, but are relatively consistent within any one family. | * These subtypes differ in their characteristic signs and symptoms and risk of specific [[tumor]]s, but are relatively consistent within any one family. | ||
* Multiple endocrine neoplasia type 2A is characterized by the presence of [[medullary thyroid carcinoma]], [[pheochromocytoma]], and [[parathyroid]] [[hyperplasia]] or [[tumor]]. | * Multiple endocrine neoplasia type 2A is characterized by the presence of [[medullary thyroid carcinoma]], [[pheochromocytoma]], and [[parathyroid]] [[hyperplasia]] or [[tumor]]. | ||
* Multiple endocrine neoplasia type 2B is characterized by the presence of [[pheochromocytoma]], [[mucocutaneous]] [[neuroma]], and [[medullary thyroid cancer]]. | * Multiple endocrine neoplasia type 2B is characterized by the presence of [[pheochromocytoma]], [[mucocutaneous]] [[neuroma]], and [[medullary thyroid cancer]]. | ||
* The following flowchart depicts the classification of multiple endocrine neoplasia type 2. | * The following flowchart depicts the classification of multiple endocrine neoplasia type 2. | ||
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{{Familytree/start}} | {{Familytree/start}} | ||
{{Familytree| | | | | | | | | | {{Familytree| | | | | | | | | | | | | A01 | | | | |A01= Multiple endocrine neoplasia type 2}} | ||
{{Familytree| | | | | | |,|-|- | {{Familytree| | | | | | | | |,|-|-|-|-|^|-|-|-|-|.|}} | ||
{{Familytree| | | | | | | {{Familytree| | | | | | | | B01 | | | | | | | | B02 |B01= Multiple endocrine neoplasia type 2A|B02= Multiple endocrine neoplasia type 2B}} | ||
{{Familytree| | |,|-|-|-| | {{Familytree| | |,|-|-|-|v|-|^|-|v|-|-|-|.| | | |!| |}} | ||
{{Familytree| | C01 | | C02 | | C03 | | C04 | | C05 |C01= Multiple endocrine neoplasia type 2A classical|C02= Multiple endocrine neoplasia type 2A with cutaneous lichen [[amyloidosis]]|C03= Multiple endocrine neoplasia type 2A with [[Hirschsprung disease]]|C04= [[Familial medullary thyroid carcinoma]] without [[pheochromocytoma]] or [[parathyroid]] hyperplasia|C05= [[Medullary thyroid cancer]], [[pheochromocytoma]], marfanoid habitus, and [[mucosal]] [[neuroma]]s or [[intestinal]] [[ganglioneuroma]]s}} | {{Familytree| | C01 | | C02 | | C03 | | C04 | | C05 |C01= Multiple endocrine neoplasia type 2A classical|C02= Multiple endocrine neoplasia type 2A with [[cutaneous]] [[lichen]] [[amyloidosis]]|C03= Multiple endocrine neoplasia type 2A with [[Hirschsprung disease]]|C04= [[Familial medullary thyroid carcinoma]] without [[pheochromocytoma]] or [[parathyroid]] [[hyperplasia]]|C05= [[Medullary thyroid cancer]], [[pheochromocytoma]],[[ marfanoid]] habitus, and [[mucosal]] [[neuroma]]s or [[intestinal]] [[ganglioneuroma]]s}} | ||
{{Familytree/end}} | {{Familytree/end}} | ||
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[[CAtegory:Diseases]] | [[CAtegory:Diseases]] | ||
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[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
[[Category:Up-To-Date]] | [[Category:Up-To-Date]] | ||
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Latest revision as of 16:13, 6 July 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2] Sogand Goudarzi, MD [3]
Overview
Multiple endocrine neoplasia type 2 may be classified according to the types of tumor involved into 2 subtypes: multiple endocrine neoplasia type 2A and multiple endocrine neoplasia type 2B.
Classification
Multiple endocrine neoplasia type 2 (MEN2) can be further divided into three subtypes: type 2A, type 2B, and familial medullary thyroid carcinoma (FMTC).[1][2]
- These subtypes differ in their characteristic signs and symptoms and risk of specific tumors, but are relatively consistent within any one family.
- Multiple endocrine neoplasia type 2A is characterized by the presence of medullary thyroid carcinoma, pheochromocytoma, and parathyroid hyperplasia or tumor.
- Multiple endocrine neoplasia type 2B is characterized by the presence of pheochromocytoma, mucocutaneous neuroma, and medullary thyroid cancer.
- The following flowchart depicts the classification of multiple endocrine neoplasia type 2.
Multiple endocrine neoplasia type 2 | |||||||||||||||||||||||||||||||||||||||||
Multiple endocrine neoplasia type 2A | Multiple endocrine neoplasia type 2B | ||||||||||||||||||||||||||||||||||||||||
Multiple endocrine neoplasia type 2A classical | Multiple endocrine neoplasia type 2A with cutaneous lichen amyloidosis | Multiple endocrine neoplasia type 2A with Hirschsprung disease | Familial medullary thyroid carcinoma without pheochromocytoma or parathyroid hyperplasia | Medullary thyroid cancer, pheochromocytoma,marfanoid habitus, and mucosal neuromas or intestinal ganglioneuromas | |||||||||||||||||||||||||||||||||||||
References
- ↑ Wells SA, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF; et al. (2015). "Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma". Thyroid. 25 (6): 567–610. doi:10.1089/thy.2014.0335. PMC 4490627. PMID 25810047.
- ↑ Hansford, J. R (2000). "Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesis". Journal of Medical Genetics. 37 (11): 817–827. doi:10.1136/jmg.37.11.817. ISSN 1468-6244.