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{{Metabolic syndrome}}
{{Metabolic syndrome}}


{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [mailto:psingh@perfuse.org]
{{CMG}}; {{AE}} [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com]; {{RT}}


==Overview==
==Overview==
[[Metabolic syndrome]] is becoming more and more common in the United States. Researchers are not sure whether the syndrome is due to one single cause, but all of the risks for the syndrome are related to [[obesity]].
Common risk factors in the development of metabolic syndrome include [[insulin]] resistance, aging, positive [[family history]], lack of [[physical exercise]], [[Menopause|postmenopause]], [[smoking]], low economic status, high [[carbohydrate]] diet, [[atypical antipsychotics]] like [[clozapine]], and soft drink consumption.


== Risks for metabolic syndrome are:==
== Risk Factors==
 
Common [[risk factors]] in the development of metabolic syndrome include:<ref name="pmid12588201">{{cite journal |author=Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB |title=The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994 |journal=[[Archives of Internal Medicine]] |volume=163 |issue=4 |pages=427–36 |year=2003 |month=February |pmid=12588201|pmc=3146257 |doi= |url=}}</ref><ref name="pmid10335688">{{cite journal |author=Wilson PW, Kannel WB, Silbershatz H, D'Agostino RB |title=Clustering of metabolic factors and coronary heart disease |journal=[[Archives of Internal Medicine]] |volume=159 |issue=10 |pages=1104–9 |year=1999 |month=May |pmid=10335688 |doi= |url=}}</ref><ref name="pmid14988303">{{cite journal |author=Palaniappan L, Carnethon MR, Wang Y, ''et al.'' |title=Predictors of the incident metabolic syndrome in adults: the Insulin Resistance Atherosclerosis Study |journal=[[Diabetes Care]] |volume=27 |issue=3 |pages=788–93 |year=2004 |month=March |pmid=14988303 |doi= |url=}}</ref><ref name="pmid14988301">{{cite journal |author=Pankow JS, Jacobs DR, Steinberger J, Moran A, Sinaiko AR |title=Insulin resistance and cardiovascular disease risk factors in children of parents with the insulin resistance (metabolic) syndrome |journal=[[Diabetes Care]] |volume=27 |issue=3 |pages=775–80 |year=2004 |month=March |pmid=14988301 |doi= |url=}}</ref><ref name="pmid15298351">{{cite journal |author=Mills GW, Avery PJ, McCarthy MI, ''et al.'' |title=Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes |journal=[[Diabetologia]] |volume=47 |issue=4 |pages=732–8 |year=2004 |month=April |pmid=15298351 |doi=10.1007/s00125-004-1338-2 |url=}}</ref>
* Extra weight around the middle and upper parts of the body (central obesity). The body may be described as "apple-shaped."
*Central [[obesity]]
* Insulin resistance, in which the body cannot use insulin effectively.
* [[Insulin resistance]]
* [[Geriatrics|Aging]]
* [[Geriatrics|Aging]]
* [[Genetics]] and family history
* Positive [[family history]]
* Hormonal changes
* Hormonal changes
* Lack of exercise  
* Lack of [[physical exercise]] <ref name="pmid16009797">{{cite journal |author=LaMonte MJ, Barlow CE, Jurca R, Kampert JB, Church TS, Blair SN |title=Cardiorespiratory fitness is inversely associated with the incidence of metabolic syndrome: a prospective study of men and women |journal=[[Circulation]] |volume=112 |issue=4 |pages=505–12 |year=2005 |month=July |pmid=16009797 |doi=10.1161/CIRCULATIONAHA.104.503805 |url=}}</ref>
People who have metabolic syndrome often have two other problems that can either cause the condition or make it worse:
* Postmenopausal status
* [[Hypercoagulable state|Excess blood clotting]]
* [[Smoking]]
* Low levels of [[inflammation]] throughout the body
* Low economic status
* High [[carbohydrate]] diet
* [[Atypical antipsychotics]] like [[clozapine]]<ref name="pmid16816234">{{cite journal |author=Lamberti JS, Olson D, Crilly JF, ''et al.'' |title=Prevalence of the metabolic syndrome among patients receiving clozapine |journal=[[The American Journal of Psychiatry]] |volume=163 |issue=7 |pages=1273–6 |year=2006 |month=July |pmid=16816234 |doi=10.1176/appi.ajp.163.7.1273 |url=}}</ref>
* Soft drink consumption <ref name="pmid17646581">{{cite journal |author=Dhingra R, Sullivan L, Jacques PF, ''et al.'' |title=Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community |journal=[[Circulation]] |volume=116 |issue=5 |pages=480–8 |year=2007 |month=July |pmid=17646581 |doi=10.1161/CIRCULATIONAHA.107.689935 |url=}}</ref>
* [[Coagulopathies]]
 
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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[[Category:Cardiology]]
[[Category:Cardiology]]
[[Category:Endocrinology]]
[[Category:Endocrinology]]
[[Category:Genetic disorders]]
[[Category:Metabolic disorders]]
[[Category:Rheumatology]]
[[Category:Rheumatology]]
[[Category:Overview complete]]
[[Category:Template complete]]
[[Category:Medical conditions related to obesity]]
[[Category:Syndromes]]
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Latest revision as of 16:41, 16 October 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Priyamvada Singh, M.B.B.S. [2]; Raviteja Guddeti, M.B.B.S. [3]

Overview

Common risk factors in the development of metabolic syndrome include insulin resistance, aging, positive family history, lack of physical exercise, postmenopause, smoking, low economic status, high carbohydrate diet, atypical antipsychotics like clozapine, and soft drink consumption.

Risk Factors

Common risk factors in the development of metabolic syndrome include:[1][2][3][4][5]

References

  1. Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB (2003). "The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994". Archives of Internal Medicine. 163 (4): 427–36. PMC 3146257. PMID 12588201. Unknown parameter |month= ignored (help)
  2. Wilson PW, Kannel WB, Silbershatz H, D'Agostino RB (1999). "Clustering of metabolic factors and coronary heart disease". Archives of Internal Medicine. 159 (10): 1104–9. PMID 10335688. Unknown parameter |month= ignored (help)
  3. Palaniappan L, Carnethon MR, Wang Y; et al. (2004). "Predictors of the incident metabolic syndrome in adults: the Insulin Resistance Atherosclerosis Study". Diabetes Care. 27 (3): 788–93. PMID 14988303. Unknown parameter |month= ignored (help)
  4. Pankow JS, Jacobs DR, Steinberger J, Moran A, Sinaiko AR (2004). "Insulin resistance and cardiovascular disease risk factors in children of parents with the insulin resistance (metabolic) syndrome". Diabetes Care. 27 (3): 775–80. PMID 14988301. Unknown parameter |month= ignored (help)
  5. Mills GW, Avery PJ, McCarthy MI; et al. (2004). "Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes". Diabetologia. 47 (4): 732–8. doi:10.1007/s00125-004-1338-2. PMID 15298351. Unknown parameter |month= ignored (help)
  6. LaMonte MJ, Barlow CE, Jurca R, Kampert JB, Church TS, Blair SN (2005). "Cardiorespiratory fitness is inversely associated with the incidence of metabolic syndrome: a prospective study of men and women". Circulation. 112 (4): 505–12. doi:10.1161/CIRCULATIONAHA.104.503805. PMID 16009797. Unknown parameter |month= ignored (help)
  7. Lamberti JS, Olson D, Crilly JF; et al. (2006). "Prevalence of the metabolic syndrome among patients receiving clozapine". The American Journal of Psychiatry. 163 (7): 1273–6. doi:10.1176/appi.ajp.163.7.1273. PMID 16816234. Unknown parameter |month= ignored (help)
  8. Dhingra R, Sullivan L, Jacques PF; et al. (2007). "Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community". Circulation. 116 (5): 480–8. doi:10.1161/CIRCULATIONAHA.107.689935. PMID 17646581. Unknown parameter |month= ignored (help)

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