Merkel cell cancer staging: Difference between revisions

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** Involvement of [[lymph nodes]], and  
** Involvement of [[lymph nodes]], and  
** Metastasis
** Metastasis
* The stages of Merkel cell carcinoma are shown in the table below:
* The stages of Merkel cell carcinoma are shown in the table below:<ref name="pmid27198511">{{cite journal |vauthors=Harms KL, Healy MA, Nghiem P, Sober AJ, Johnson TM, Bichakjian CK, Wong SL |title=Analysis of Prognostic Factors from 9387 Merkel Cell Carcinoma Cases Forms the Basis for the New 8th Edition AJCC Staging System |journal=Ann. Surg. Oncol. |volume=23 |issue=11 |pages=3564–3571 |date=October 2016 |pmid=27198511 |doi=10.1245/s10434-016-5266-4 |url=}}</ref>


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{| {{table}} cellpadding="4" cellspacing="0" style="border:#c9c9c9 1px solid; margin: 1em 1em 1em 0; border-collapse: collapse;"

Revision as of 17:45, 17 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]

Overview

The staging of Merkel cell cancer is based on the TNM staging system.

Staging

  • According to the TNM staging system, merkel cell cancer is classified into 4 stages based on the following:
  • The stages of Merkel cell carcinoma are shown in the table below:[1]
Stage Primary Tumor (T) Lymph Node (N) Metastasis (M)
0 In situ
  • No regional lymph node metastasis
  • No distant metastasis
IA ≤2 cm
  • Nodes negative by pathologic exam
  • No distant metastasis
IB ≤2 cm
  • Nodes negative by clinical exam (no pathologic node exam performed)
  • No distant metastasis
IIA >2 cm
  • Nodes negative by pathologic exam
  • No distant metastasis
IIB >2 cm
  • Nodes negative by clinical exam (no pathologic node exam performed)
  • No distant metastasis
IIC Invades bone, muscle and cartilage
  • No regional lymph node metastasis detected
  • No distant metastasis
IIIA Any size tumor (includes invading tumors)
  • Micrometastasis (which are diagnosed after sentinel or elective lymphadenectomy)
  • No distant metastasis
IIIB Any size tumor (includes invading tumors) Postive for:
  • Macrometastasis
  • In transit metastasis
  • No distant metastasis
IV Any size tumor (includes invading tumors)
  • Any lymph node metastasis
  • Metastasis beyond regional lymph nodes

References

  1. Harms KL, Healy MA, Nghiem P, Sober AJ, Johnson TM, Bichakjian CK, Wong SL (October 2016). "Analysis of Prognostic Factors from 9387 Merkel Cell Carcinoma Cases Forms the Basis for the New 8th Edition AJCC Staging System". Ann. Surg. Oncol. 23 (11): 3564–3571. doi:10.1245/s10434-016-5266-4. PMID 27198511.