Merkel cell cancer classification: Difference between revisions
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{{Merkel cell cancer}} | {{Merkel cell cancer}} | ||
{{CMG}} {{AE}} {{VKG}} | |||
==Overview== | |||
[[Merkel cell carcinoma]] is classified into 3 subgroups: trabecular, intermediate, and small cell. | |||
==Classification== | ==Classification== | ||
Histologically, MCC has been classified into three distinct subtypes: | Histologically, [[MCC]] has been classified into three distinct subtypes:<ref name="pmid16466578">{{cite journal |vauthors=Koljonen V |title=Merkel cell carcinoma |journal=World J Surg Oncol |volume=4 |issue= |pages=7 |date=February 2006 |pmid=16466578 |pmc=1382229 |doi=10.1186/1477-7819-4-7 |url=}}</ref><ref name="pmid3724197">{{cite journal |vauthors=Suster S, Ronnen M, Lin E, Shewach-Millet M |title=Trabecular carcinoma of the skin simulating metastatic disease |journal=J Surg Oncol |volume=32 |issue=2 |pages=73–5 |date=June 1986 |pmid=3724197 |doi= |url=}}</ref><ref name="pmid1698390">{{cite journal |vauthors=Johansson L, Tennvall J, Akerman M |title=Immunohistochemical examination of 25 cases of Merkel cell carcinoma: a comparison with small cell carcinoma of the lung and oesophagus, and a review of the literature |journal=APMIS |volume=98 |issue=8 |pages=741–52 |date=August 1990 |pmid=1698390 |doi= |url=}}</ref> | ||
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!Subtype | |||
== | !Pattern | ||
!Histology studies | |||
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| | |'''Trabecular type''' | ||
|Classic pattern | |||
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* Large-cells | |||
* High density [[granules]] | |||
* Organoid [[Cluster (epidemiology)|clusters]] of cells | |||
* [[Trabeculae]] with ribbons | |||
* Most commonly occurs in [[hair follicles]] | |||
|- | |- | ||
| | |'''Intermediate''' '''type''' | ||
|[[Solid]] pattern | |||
| | |||
* Most common subtype | |||
* Compactly arranged cells | |||
* [[Cytoplasm]] is less abundant in the cells | |||
* [[Mitotic]] figures are positive | |||
* [[Necrosis]] is positive | |||
* Intermediate type may invade the [[Epidermis (skin)|epidermis]] | |||
* More aggressive subtype when compared to the trabecular type | |||
* | |||
|- | |- | ||
| | |'''Small cell type''' | ||
| | |[[Diffuse]] pattern | ||
| | |||
* Few high density [[granules]] | |||
* Arises in the [[dermis]] | |||
* Sheets of solid and clusters of cells | |||
* Mimics other small cell tumours | |||
|} | |} | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | [[Category:Oncology]] | ||
[[Category:Medicine]] | |||
[[Category:Dermatology]] | |||
[[Category:Surgery]] | |||
Latest revision as of 15:35, 9 January 2019
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Merkel cell cancer classification On the Web |
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Risk calculators and risk factors for Merkel cell cancer classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Merkel cell carcinoma is classified into 3 subgroups: trabecular, intermediate, and small cell.
Classification
Histologically, MCC has been classified into three distinct subtypes:[1][2][3]
| Subtype | Pattern | Histology studies |
|---|---|---|
| Trabecular type | Classic pattern |
|
| Intermediate type | Solid pattern | |
| Small cell type | Diffuse pattern |
References
- ↑ Koljonen V (February 2006). "Merkel cell carcinoma". World J Surg Oncol. 4: 7. doi:10.1186/1477-7819-4-7. PMC 1382229. PMID 16466578.
- ↑ Suster S, Ronnen M, Lin E, Shewach-Millet M (June 1986). "Trabecular carcinoma of the skin simulating metastatic disease". J Surg Oncol. 32 (2): 73–5. PMID 3724197.
- ↑ Johansson L, Tennvall J, Akerman M (August 1990). "Immunohistochemical examination of 25 cases of Merkel cell carcinoma: a comparison with small cell carcinoma of the lung and oesophagus, and a review of the literature". APMIS. 98 (8): 741–52. PMID 1698390.