Medullary thyroid cancer causes: Difference between revisions
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==Overview== | ==Overview== | ||
Medullary thyroid cancer is [[Cause|caused]] by a [[mutation]] in the [[RET proto-oncogene]]. | |||
==Causes== | ==Causes== | ||
* Development of medullary thyroid cancer is the result of | * Development of sporadic medullary thyroid cancer is the result of [[somatic mutation]] of [[RET proto-oncogene]].<ref>Thyroid Cancer Cancer.gov (2015). http://www.cancer.gov/types/thyroid/hp/thyroid-treatment-pdq#link/stoc_h2_2- Accessed on October, 29 2015</ref><ref name="pmid9860226">{{cite journal |vauthors=Raue F |title=German medullary thyroid carcinoma/multiple endocrine neoplasia registry. German MTC/MEN Study Group. Medullary Thyroid Carcinoma/Multiple Endocrine Neoplasia Type 2 |journal=Langenbecks Arch Surg |volume=383 |issue=5 |pages=334–6 |date=October 1998 |pmid=9860226 |doi= |url=}}</ref><ref name="pmid8640806">{{cite journal |vauthors=Marsh DJ, Andrew SD, Eng C, Learoyd DL, Capes AG, Pojer R, Richardson AL, Houghton C, Mulligan LM, Ponder BA, Robinson BG |title=Germline and somatic mutations in an oncogene: RET mutations in inherited medullary thyroid carcinoma |journal=Cancer Res. |volume=56 |issue=6 |pages=1241–3 |date=March 1996 |pmid=8640806 |doi= |url=}}</ref> | ||
*[[Hereditary]] form of medullary thyroid cancer is the result of [[germline mutation]] of [[RET proto-oncogene]] that are associated with [[Multiple endocrine neoplasia type 2|MEN 2 syndromes]]. | |||
==Reference== | ==Reference== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Endocrine system]] | |||
[[Category:Endocrinology]] | |||
[[Category:Otolaryngology]] | |||
[[Category:Disease]] | |||
[[Category:Genetic disorders]] | |||
[[Category:Types of cancer]] | |||
[[Category:Hereditary cancers]] | |||
Latest revision as of 17:39, 29 August 2019
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Differentiating Medullary thyroid cancer from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Medullary thyroid cancer is caused by a mutation in the RET proto-oncogene.
Causes
- Development of sporadic medullary thyroid cancer is the result of somatic mutation of RET proto-oncogene.[1][2][3]
- Hereditary form of medullary thyroid cancer is the result of germline mutation of RET proto-oncogene that are associated with MEN 2 syndromes.
Reference
- ↑ Thyroid Cancer Cancer.gov (2015). http://www.cancer.gov/types/thyroid/hp/thyroid-treatment-pdq#link/stoc_h2_2- Accessed on October, 29 2015
- ↑ Raue F (October 1998). "German medullary thyroid carcinoma/multiple endocrine neoplasia registry. German MTC/MEN Study Group. Medullary Thyroid Carcinoma/Multiple Endocrine Neoplasia Type 2". Langenbecks Arch Surg. 383 (5): 334–6. PMID 9860226.
- ↑ Marsh DJ, Andrew SD, Eng C, Learoyd DL, Capes AG, Pojer R, Richardson AL, Houghton C, Mulligan LM, Ponder BA, Robinson BG (March 1996). "Germline and somatic mutations in an oncogene: RET mutations in inherited medullary thyroid carcinoma". Cancer Res. 56 (6): 1241–3. PMID 8640806.