Medullary thyroid cancer causes

	Medullary thyroid cancer Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Medullary thyroid cancer from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Staging
History and Symptoms
Physical Examination
Laboratory Findings
CT
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Medullary thyroid cancer causes On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Medullary thyroid cancer causes All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Medullary thyroid cancer causes
CDC on Medullary thyroid cancer causes
Medullary thyroid cancer causes in the news
Blogs on Medullary thyroid cancer causes
Directions to Hospitals Treating Medullary thyroid cancer
Risk calculators and risk factors for Medullary thyroid cancer causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Medullary thyroid cancer is caused by a mutation in the RET proto-oncogene.

Development of sporadic medullary thyroid cancer is the result of somatic mutation of RET proto-oncogene.^[1]^[2]^[3]
Hereditary form of medullary thyroid cancer is the result of germline mutation of RET proto-oncogene that are associated with MEN 2 syndromes.

↑ Thyroid Cancer Cancer.gov (2015). http://www.cancer.gov/types/thyroid/hp/thyroid-treatment-pdq#link/stoc_h2_2- Accessed on October, 29 2015
↑ Raue F (October 1998). "German medullary thyroid carcinoma/multiple endocrine neoplasia registry. German MTC/MEN Study Group. Medullary Thyroid Carcinoma/Multiple Endocrine Neoplasia Type 2". Langenbecks Arch Surg. 383 (5): 334–6. PMID 9860226.
↑ Marsh DJ, Andrew SD, Eng C, Learoyd DL, Capes AG, Pojer R, Richardson AL, Houghton C, Mulligan LM, Ponder BA, Robinson BG (March 1996). "Germline and somatic mutations in an oncogene: RET mutations in inherited medullary thyroid carcinoma". Cancer Res. 56 (6): 1241–3. PMID 8640806.