Mast cell leukemia natural history, complications and prognosis: Difference between revisions
Jump to navigation
Jump to search
Farima Kahe (talk | contribs) No edit summary |
|||
| (8 intermediate revisions by the same user not shown) | |||
| Line 7: | Line 7: | ||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
===Natural History=== | ===Natural History=== | ||
If left untreated, patients with [[mast cell]] leukemia may progress to develop [[hepatomegaly]], [[splenomegaly]], [[Lymphadenopathy|lymph nodes enlargement]], bone abnormalities, [[ascites]], and [[weight loss]].<ref name="JorisGeorgin-Lavialle2012">{{cite journal|last1=Joris|first1=Magalie|last2=Georgin-Lavialle|first2=Sophie|last3=Chandesris|first3=Marie-Olivia|last4=Lhermitte|first4=Ludovic|last5=Claisse|first5=Jean-François|last6=Canioni|first6=Danielle|last7=Hanssens|first7=Katia|last8=Damaj|first8=Gandhi|last9=Hermine|first9=Olivier|last10=Hamidou|first10=Mohammed|title=Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive|journal=Case Reports in Hematology|volume=2012|year=2012|pages=1–6|issn=2090-6560|doi=10.1155/2012/517546}}</ref> Mast cell leukemia is by far an incurable disease with an aggressive behavior.<ref name="JorisGeorgin-Lavialle2012">{{cite journal|last1=Joris|first1=Magalie|last2=Georgin-Lavialle|first2=Sophie|last3=Chandesris|first3=Marie-Olivia|last4=Lhermitte|first4=Ludovic|last5=Claisse|first5=Jean-François|last6=Canioni|first6=Danielle|last7=Hanssens|first7=Katia|last8=Damaj|first8=Gandhi|last9=Hermine|first9=Olivier|last10=Hamidou|first10=Mohammed|title=Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive|journal=Case Reports in Hematology|volume=2012|year=2012|pages=1–6|issn=2090-6560|doi=10.1155/2012/517546}}</ref> | * The symptoms of mast cell leukemia usually observed in range 5-76 years.<ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> | ||
*The symptoms of mast cell leukemia typically develop by [[Flushing|flushes]], [[fever]], [[malaise]], [[diarrhea]], [[tachycardia]], [[Pollakisuria|pollakiuria]], [[neuropsychiatric]] [[Symptom|symptoms]] and severe prefracturar [[osteoporosis]] years after exposure the majority of [[Patient|patients]] suffered from [[asthenia]], severe weight loss and [[anorexia]].<ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> | |||
*If left untreated, patients with [[mast cell]] leukemia may progress to develop [[hepatomegaly]], [[splenomegaly]], [[Lymphadenopathy|lymph nodes enlargement]], bone abnormalities, [[ascites]], and [[weight loss]].<ref name="JorisGeorgin-Lavialle2012">{{cite journal|last1=Joris|first1=Magalie|last2=Georgin-Lavialle|first2=Sophie|last3=Chandesris|first3=Marie-Olivia|last4=Lhermitte|first4=Ludovic|last5=Claisse|first5=Jean-François|last6=Canioni|first6=Danielle|last7=Hanssens|first7=Katia|last8=Damaj|first8=Gandhi|last9=Hermine|first9=Olivier|last10=Hamidou|first10=Mohammed|title=Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive|journal=Case Reports in Hematology|volume=2012|year=2012|pages=1–6|issn=2090-6560|doi=10.1155/2012/517546}}</ref> Mast cell leukemia is by far an incurable disease with an aggressive behavior.<ref name="JorisGeorgin-Lavialle2012">{{cite journal|last1=Joris|first1=Magalie|last2=Georgin-Lavialle|first2=Sophie|last3=Chandesris|first3=Marie-Olivia|last4=Lhermitte|first4=Ludovic|last5=Claisse|first5=Jean-François|last6=Canioni|first6=Danielle|last7=Hanssens|first7=Katia|last8=Damaj|first8=Gandhi|last9=Hermine|first9=Olivier|last10=Hamidou|first10=Mohammed|title=Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive|journal=Case Reports in Hematology|volume=2012|year=2012|pages=1–6|issn=2090-6560|doi=10.1155/2012/517546}}</ref> | |||
===Complications=== | ===Complications=== | ||
Common complications of mast cell leukemia include:<ref name="JorisGeorgin-Lavialle2012">{{cite journal|last1=Joris|first1=Magalie|last2=Georgin-Lavialle|first2=Sophie|last3=Chandesris|first3=Marie-Olivia|last4=Lhermitte|first4=Ludovic|last5=Claisse|first5=Jean-François|last6=Canioni|first6=Danielle|last7=Hanssens|first7=Katia|last8=Damaj|first8=Gandhi|last9=Hermine|first9=Olivier|last10=Hamidou|first10=Mohammed|title=Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive|journal=Case Reports in Hematology|volume=2012|year=2012|pages=1–6|issn=2090-6560|doi=10.1155/2012/517546}}</ref> | Common complications of mast cell leukemia include:<ref name="JorisGeorgin-Lavialle2012">{{cite journal|last1=Joris|first1=Magalie|last2=Georgin-Lavialle|first2=Sophie|last3=Chandesris|first3=Marie-Olivia|last4=Lhermitte|first4=Ludovic|last5=Claisse|first5=Jean-François|last6=Canioni|first6=Danielle|last7=Hanssens|first7=Katia|last8=Damaj|first8=Gandhi|last9=Hermine|first9=Olivier|last10=Hamidou|first10=Mohammed|title=Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive|journal=Case Reports in Hematology|volume=2012|year=2012|pages=1–6|issn=2090-6560|doi=10.1155/2012/517546}}</ref> | ||
| Line 21: | Line 25: | ||
*[[Hypoalbuminemia]] | *[[Hypoalbuminemia]] | ||
*Excess of [[bone marrow]] [[Blast|blasts]] | *Excess of [[bone marrow]] [[Blast|blasts]] | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Latest revision as of 17:28, 3 December 2018
|
Mast cell leukemia Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Mast cell leukemia natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Mast cell leukemia natural history, complications and prognosis |
|
FDA on Mast cell leukemia natural history, complications and prognosis |
|
CDC on Mast cell leukemia natural history, complications and prognosis |
|
Mast cell leukemia natural history, complications and prognosis in the news |
|
Blogs on Mast cell leukemia natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2], Sogand Goudarzi, MD [3]
Overview
If left untreated, patients with mast cell leukemia may progress to develop weight loss, ascites, and bone abnormalities. Common complications of mast cell leukemia include hepatosplenomegaly, lymphadenopathy, and osteoporosis. Prognosis is generally poor, and the median survival time is less than six months.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of mast cell leukemia usually observed in range 5-76 years.[1]
- The symptoms of mast cell leukemia typically develop by flushes, fever, malaise, diarrhea, tachycardia, pollakiuria, neuropsychiatric symptoms and severe prefracturar osteoporosis years after exposure the majority of patients suffered from asthenia, severe weight loss and anorexia.[1]
- If left untreated, patients with mast cell leukemia may progress to develop hepatomegaly, splenomegaly, lymph nodes enlargement, bone abnormalities, ascites, and weight loss.[2] Mast cell leukemia is by far an incurable disease with an aggressive behavior.[2]
Complications
Common complications of mast cell leukemia include:[2]
Prognosis
Prognosis is generally poor, and the median survival time is less than six months.[1]
- Advanced age
- History of weight loss
- Anemia
- Thrombocytopenia
- Hypoalbuminemia
- Excess of bone marrow blasts
References
- ↑ 1.0 1.1 1.2 Georgin-Lavialle, S.; Lhermitte, L.; Dubreuil, P.; Chandesris, M.-O.; Hermine, O.; Damaj, G. (2012). "Mast cell leukemia". Blood. 121 (8): 1285–1295. doi:10.1182/blood-2012-07-442400. ISSN 0006-4971.
- ↑ 2.0 2.1 2.2 Joris, Magalie; Georgin-Lavialle, Sophie; Chandesris, Marie-Olivia; Lhermitte, Ludovic; Claisse, Jean-François; Canioni, Danielle; Hanssens, Katia; Damaj, Gandhi; Hermine, Olivier; Hamidou, Mohammed (2012). "Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive". Case Reports in Hematology. 2012: 1–6. doi:10.1155/2012/517546. ISSN 2090-6560.