Mast cell leukemia laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2], Sogand Goudarzi, MD [3]


Laboratory findings consistent with the diagnosis of mast cell leukemia include abnormal complete blood count, biochemistry, and immunohistochemistry.

Mast cell leukemia laboratory findings

Complete Blood Count

On complete blood count, characteristic findings of mast cell leukemia include:[1][2]


Total serum tryptase level is elevated in mast cell leukemia.[4]


On immunohistochemistry, characteristic findings of mast cell leukemia include:[1][2]

  • Leukemic mast cells strongly express:[2]
  • Abnormal mast cells ususally express:[2]
  • Other cell surface markers expressed by mast cells are:[2][5][6]


  1. 1.0 1.1 1.2 Joris, Magalie; Georgin-Lavialle, Sophie; Chandesris, Marie-Olivia; Lhermitte, Ludovic; Claisse, Jean-François; Canioni, Danielle; Hanssens, Katia; Damaj, Gandhi; Hermine, Olivier; Hamidou, Mohammed (2012). "Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive". Case Reports in Hematology. 2012: 1–6. doi:10.1155/2012/517546. ISSN 2090-6560.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Georgin-Lavialle, S.; Lhermitte, L.; Dubreuil, P.; Chandesris, M.-O.; Hermine, O.; Damaj, G. (2012). "Mast cell leukemia". Blood. 121 (8): 1285–1295. doi:10.1182/blood-2012-07-442400. ISSN 0006-4971.
  3. Bauer, James; Longo, Walter; Yang, David (2017). "Mast Cell Leukemia: Review of a Rare Disease and Case Report of Prolonged Survival after Allogeneic Stem Cell Transplant". Human Pathology: Case Reports. 10: 46–49. doi:10.1016/j.ehpc.2017.05.003. ISSN 2214-3300.
  4. Biochemistry of mast cell leukemia. Wikipedia (2015). Accessed on December 1, 2015
  5. Costopoulos, Myrto; Uzunov, Madalina; Bories, Dominique; Charlotte, Frederic; Maloum, Karim; Arock, Michel (2018). "Acute mast cell leukemia: A rare but highly aggressive hematopoietic neoplasm". Diagnostic Cytopathology. 46 (7): 639–641. doi:10.1002/dc.23965. ISSN 8755-1039.
  6. Zheng, Yalin; Nong, Lin; Liang, Li; Wang, Wei; Li, Ting (2018). "De novo mast cell leukemia without CD25 expression and KIT mutations: a rare case report in a 13-year-old child". Diagnostic Pathology. 13 (1). doi:10.1186/s13000-018-0691-2. ISSN 1746-1596.

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