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| **Medical condition of the patient. | | **Medical condition of the patient. |
| **Results of earlier medical tests. | | **Results of earlier medical tests. |
| ==Treatment==
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| There are several different options for treating Waldenström macroglobulinemia depending on stage of the disease:<ref name="Tx">Lymphoplasmacytic lymphoma. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/lymphoplasmacytic-lymphoma/?region=ab Accessed on November 6 2015 </ref>
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|
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| ====Asymptomatic/Smoldering Waldenström's Macroglobulinemia====
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| There is no treatment for asymptomatic Waldenström macroglobulinemia. Asymptomatic waldenström's macroglobulinemia can be monitored every 3-6 months.<ref name="BM">Waldenström's macroglobulinemia. Patient (2015)http://patient.info/doctor/waldenstroms-macroglobulinaemia-pro Accessed on November 10, 2015</ref> Active surveillance includes monitoring of the following laboratory parameters:
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| *Complete blood count ([[Complete blood count|CBC]]) with differential
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| *Complete metabolic panel ([[CMP-N-acetylneuraminate monooxygenase|CMP]])
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| *Immunoglobulin levels in the serum (quantitative)
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| *Serum protein electrophoresis
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|
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| ====Symptomatic Waldenström's Macroglobulinemia====
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| Symptomatic patients with waldenström macroglobulinemia are started on chemotherapy depending on the stage.<ref name="ADR">Waldenström's macroglobulinemia: prognosis and management. Blood Cancer Journal (2015)http://www.nature.com/bcj/journal/v5/n3/full/bcj201528a.html Accessed on November 13, 2015</ref>
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|
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| *Initial stage of waldenström's macroglobulinemia associated with:
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| :*[[Neuropathy]]
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| :*[[Anemia]] or [[cytopenias]]
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| :*Low-volume nodal involvement
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| :*Asymptomatic [[splenomegaly]]
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|
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| *Late stage of Waldenström's macroglobulinemia associated with:
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| :*[[Adenopathy]]
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| :*Symptomatic [[splenomegaly]]
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| :*[[Cytopenia|Cytopenias]]
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| :*[[Hyperviscosity syndrome]]
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| :*[[Neuropathy]]
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| :*Constitutional symptoms
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|
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| {| style="border: 0px; font-size: 90%; margin: 3px; width: 800px"
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| | valign="top" |
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| |+
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| ! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Treatment Regimen<ref name="ADR">Waldenström's macroglobulinemia: prognosis and management. Blood Cancer Journal (2015)http://www.nature.com/bcj/journal/v5/n3/full/bcj201528a.html Accessed on November 13, 2015</ref>
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| }}
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| ! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Drugs}}
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| ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Side effects}}
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''[[CHOP-R regimen]]'''
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| *[[Cyclophosphamide]]
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| *[[Doxorubicin]]
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| *[[Vincristine]]
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| *[[Prednisone]]
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| *[[Rituximab]]
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| *[[Nausea]]
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| *[[Alopecia]]
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| *[[Granulocytopenia]]
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| *[[Cardiotoxicity]]
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| *[[Mucositis]]
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| |
| '''[[Ibrutinib]]'''
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| *[[Ibrutinib]]
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| *[[Fatigue]]
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| *[[Cytopenia]]
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| *[[Bleeding]]
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| *[[Atrial fibrillation]]
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| *[[Opportunistic infection]]
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| |-
| |
| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| |
| '''[[Rituximab]]'''
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
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| *[[Rituximab]]
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| *Infusion related reaction
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| *[[Hepatitis B]] reaction
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| *Progressive multi-focal leukoencephaloptahy
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''FR regimen'''
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| *[[Fludarabine]]
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| *[[Rituximab]]
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| *[[Neutropenia]] (63%)
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| *[[Thrombocytopenia]]
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| *[[Pneumonia]]
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| |-
| |
| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''BDR regimen'''
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| *[[Bortezomib]]
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| *[[Dexamethasone]]
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| *[[Rituximab]]
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| *[[Peripheral neuropathy]] - reversible in 61% of patients
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| *[[Infections]]
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| |-
| |
| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''DRC regimen'''
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| *[[Dexamethasone]]
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| *[[Rituximab]]
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| *[[Cyclophosphamide]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
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| *[[Neutropenia]]
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| |-
| |
| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''CR regimen'''
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| *[[Cladribine]]
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| *[[Rituximab]]
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| *[[Anemia]]
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| *Neurological symptoms
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| *Symptomatic [[cryoglobulinemia]]
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| *[[Thrombocytopenia]]
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| |-
| |
| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''IR regimen'''
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| *[[Ibrutinib]]
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| *[[Rituximab]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" |
| |
| *[[Anemia]]
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| *Neurological symptoms
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| *Symptomatic [[cryoglobulinemia]]
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| *[[Thrombocytopenia]]
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| *[[Atrial fibrillation]]
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| |-
| |
| |}
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|
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| ====Hyperviscosity syndrome====
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| *Waldenström macroglobulinemia complicated with [[hyperviscosity syndrome]] is a medical emergency and requires prompt treatment with plasmapheresis.<ref name="ADR">Waldenström's macroglobulinemia: prognosis and management. Blood Cancer Journal (2015)http://www.nature.com/bcj/journal/v5/n3/full/bcj201528a.html Accessed on November 13, 2015</ref>
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| *[[Plasmapheresis]] temporarily lowers [[IgM]] levels by removing some of the abnormal IgM from the blood, which makes blood thinner.
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| *Plasmapheresis is usually given until chemotherapy starts to work.
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| *Plasmapheresis is combined with chemotherapy to control the disease for a longer period of time.
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| ===Surgery===
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| [[Stem cell transplant]] is usually reserved for patients with either relapse or refractory Waldenström's macroglobulinemia.<ref name="sure">Waldenström's macroglobulinemia: prognosis and management. Blood Cancer Journal (2015) http://www.nature.com/bcj/journal/v5/n3/full/bcj201528a.html Accessed on November 13, 2015</ref>
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| ===Primary Prevention===
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| Primary prevention of Waldenström macroglobulinemia depends on the type of risk factor causing the disease.<ref name="PP">Waldenström's macroglobulinemia. American Cancer Society. (2015)http://www.cancer.org/cancer/waldenstrommacroglobulinemia/detailedguide/waldenstrom-macroglobulinemia-prevention Accessed on November 11, 2015</ref>
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| ===Modifiable risk factors===
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| *[[Hepatitis C]]
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| ===Non-modifiable risk factors===
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| *Age > 50
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| *Male gender
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| *Race - White
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| *Hereditary- [[Monoclonal gammopathy of undetermined significance]]
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| ===Secondary Prevention===
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| There are no established measures for the secondary prevention of Waldenström's macroglobulinemia.
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|
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| One or more of the following treatments can be given for lymphoplasmacytic lymphoma.
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| ===Watchful waiting===
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| Watchful waiting (also called active surveillance) may be offered for lymphoplasmacytic lymphoma because it develops slowly and may not need to be treated right away. The healthcare team will carefully monitor the person with lymphoplasmacytic lymphoma and start treatment when symptoms appear, such as hyperviscosity syndrome, or there are signs that the disease is progressing more quickly.
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| ===Chemotherapy===
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| *People with lymphoplasmacytic lymphoma who have symptoms or hyperviscosity syndrome are usually given chemotherapy. Chemotherapy drugs that may be used with or without prednisone include:
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| **Chlorambucil (Leukeran)
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| **Fludarabine (Fludara)
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| **Bendamustine (Treanda)
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| **Cyclophosphamide (Cytoxan, Procytox)
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|
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| *Combinations of chemotherapy drugs that may be used include:
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| **DRC – dexamethasone (Decadron, Dexasone), rituximab (Rituxan) and cyclophosphamide
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| **BRD – bortezomib (Velcade) and rituximab, with or without dexamethasone
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| **CVP – cyclophosphamide, vincristine (Oncovin) and prednisone
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| **R-CVP – CVP with rituximab
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| **Thalidomide (Thalomid) and rituximab
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|
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| ===Targeted therapy===
| |
| *Targeted therapy uses drugs to target specific molecules (such as proteins) on the surface of cancer cells. These molecules help send signals that tell cells to grow or divide. By targeting these molecules, the drugs stop the growth and spread of cancer cells while limiting harm to normal cells.
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| *Targeted therapy drugs used alone or in combination to treat lymphoplasmacytic lymphoma include rituximab, bortezomib and ibrutinib (Imbruvica).
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| ===Immunotherapy===
| |
| *Immunotherapy works by stimulating, boosting, restoring or acting like the body’s immune system to create a response against cancer cells. Immunomodulatory drugs are a type of immunotherapy that interferes with the growth and division of cancer cells.
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| *Thalidomide is a type of immunomodulatory drug that may be used to treat lymphoplasmacytic lymphoma.
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| ===Radiation therapy===
| |
| External beam radiation therapy may be used to treat lymphoplasmacytic lymphoma that develops outside of the lymphatic system (called extralymphatic disease), but this is rare.
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| ===Stem cell transplant===
| |
| *Some people with lymphoplasmacytic lymphoma may be offered a stem cell transplant.
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| *It may be used if the lymphoma comes back (recurs) after treatment or doesn’t respond to other treatments (called refractory disease).
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| *Many people with lymphoplasmacytic lymphoma are older or may not be in good health, so a stem cell transplant may not be a good treatment option for them.
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|
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|
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| Read more: http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/more-types-of-nhl/lymphoplasmacytic-lymphoma/?region=on#ixzz5eb6iT7G6
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| ==References== | | ==References== |
| {{reflist|2}} | | {{reflist|2}} |