KCNN4: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4''', also known as '''KCNN4''', is a human [[gene]] encoding the K<sub>Ca</sub>3.1 [[protein]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3783| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
| HGNCid = 6293
| Symbol = KCNN4
| AltSymbols =; IK1; IKCA1; KCA4; KCa3.1; SK4; hIKCa1; hKCa4; hSK4
| OMIM = 602754
| ECnumber = 
| Homologene = 1696
| MGIid = 1277957
| GeneAtlas_image1 = PBB_GE_KCNN4_204401_at_tn.png
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005249 |text = voltage-gated potassium channel activity}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0015269 |text = calcium-activated potassium channel activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0050714 |text = positive regulation of protein secretion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3783
    | Hs_Ensembl = ENSG00000104783
    | Hs_RefseqProtein = NP_002241
    | Hs_RefseqmRNA = NM_002250
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 48962578
    | Hs_GenLoc_end = 48976944
    | Hs_Uniprot = O15554
    | Mm_EntrezGene = 16534
    | Mm_Ensembl = ENSMUSG00000054342
    | Mm_RefseqmRNA = NM_008433
    | Mm_RefseqProtein = NP_032459
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 24079023
    | Mm_GenLoc_end = 24093969
    | Mm_Uniprot = Q8C2E0
  }}
}}
'''Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4''', also known as '''KCNN4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3783| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The K<sub>Ca</sub>3.1 protein is part of a potentially heterotetrameric voltage-independent [[potassium channel]] that is activated by intracellular [[calcium in biology|calcium]]. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant [[calcium-activated potassium channel]] in [[T cell|T-lymphocyte]]s. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.<ref name="entrez">{{cite web | title = Entrez Gene: KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3783| accessdate = }}</ref>
}}


==See also==
==History==
The channel activity was first described in 1958 by [[György Gárdos]] in human [[erythrocytes]].<ref name="pmid13618284">{{cite journal |vauthors=Gardos G |title=The function of calcium in the potassium permeability of human erythrocytes |journal=Biochim. Biophys. Acta |volume=30 |issue=3 |pages=653–4 |year=1958 |pmid=13618284 |doi= 10.1016/0006-3002(58)90124-0|url=}}</ref> The channels is also named Gardos channel because of its discoverer.
 
== See also ==
* [[SK channel]]
* [[SK channel]]
* [[Voltage-gated potassium channel]]
* [[Voltage-gated potassium channel]]
* [[Senicapoc]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H | title = International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels | journal = Pharmacol. Rev. | volume = 57 | issue = 4 | pages = 463–72 | year = 2005 | pmid = 16382103 | doi = 10.1124/pr.57.4.9 }}
| citations =
* {{cite journal | vauthors = Ishii TM, Silvia C, Hirschberg B, Bond CT, Adelman JP, Maylie J | title = A human intermediate conductance calcium-activated potassium channel | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 21 | pages = 11651–6 | year = 1997 | pmid = 9326665 | pmc = 23567 | doi = 10.1073/pnas.94.21.11651 }}
*{{cite journal | author=Wei AD, Gutman GA, Aldrich R, ''et al.'' |title=International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 463-72 |year= 2006 |pmid= 16382103 |doi= 10.1124/pr.57.4.9 }}
* {{cite journal | vauthors = Joiner WJ, Wang LY, Tang MD, Kaczmarek LK | title = hSK4, a member of a novel subfamily of calcium-activated potassium channels | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 20 | pages = 11013–8 | year = 1997 | pmid = 9380751 | pmc = 23566 | doi = 10.1073/pnas.94.20.11013 }}
*{{cite journal | author=Ishii TM, Silvia C, Hirschberg B, ''et al.'' |title=A human intermediate conductance calcium-activated potassium channel. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11651-6 |year= 1997 |pmid= 9326665 |doi= }}
* {{cite journal | vauthors = Logsdon NJ, Kang J, Togo JA, Christian EP, Aiyar J | title = A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes | journal = J. Biol. Chem. | volume = 272 | issue = 52 | pages = 32723–6 | year = 1997 | pmid = 9407042 | doi = 10.1074/jbc.272.52.32723 }}
*{{cite journal | author=Joiner WJ, Wang LY, Tang MD, Kaczmarek LK |title=hSK4, a member of a novel subfamily of calcium-activated potassium channels. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 20 |pages= 11013-8 |year= 1997 |pmid= 9380751 |doi= }}
* {{cite journal | vauthors = Ghanshani S, Coleman M, Gustavsson P, Wu AC, Gargus JJ, Gutman GA, Dahl N, Mohrenweiser H, Chandy KG | title = Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia | journal = Genomics | volume = 51 | issue = 1 | pages = 160–1 | year = 1998 | pmid = 9693050 | doi = 10.1006/geno.1998.5333 }}
*{{cite journal | author=Logsdon NJ, Kang J, Togo JA, ''et al.'' |title=A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 32723-6 |year= 1998 |pmid= 9407042 |doi= }}
* {{cite journal | vauthors = Fanger CM, Ghanshani S, Logsdon NJ, Rauer H, Kalman K, Zhou J, Beckingham K, Chandy KG, Cahalan MD, Aiyar J | title = Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1 | journal = J. Biol. Chem. | volume = 274 | issue = 9 | pages = 5746–54 | year = 1999 | pmid = 10026195 | doi = 10.1074/jbc.274.9.5746 }}
*{{cite journal | author=Ghanshani S, Coleman M, Gustavsson P, ''et al.'' |title=Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia. |journal=Genomics |volume=51 |issue= 1 |pages= 160-1 |year= 1998 |pmid= 9693050 |doi= 10.1006/geno.1998.5333 }}
* {{cite journal | vauthors = Liu QH, Williams DA, McManus C, Baribaud F, Doms RW, Schols D, De Clercq E, Kotlikoff MI, Collman RG, Freedman BD | title = HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 9 | pages = 4832–7 | year = 2000 | pmid = 10758170 | pmc = 18318 | doi = 10.1073/pnas.090521697 }}
*{{cite journal | author=Fanger CM, Ghanshani S, Logsdon NJ, ''et al.'' |title=Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1. |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5746-54 |year= 1999 |pmid= 10026195 |doi= }}
* {{cite journal | vauthors = Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, Cahalan MD, Chandy KG | title = Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences | journal = J. Biol. Chem. | volume = 275 | issue = 47 | pages = 37137–49 | year = 2000 | pmid = 10961988 | doi = 10.1074/jbc.M003941200 }}
*{{cite journal | author=Liu QH, Williams DA, McManus C, ''et al.'' |title=HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4832-7 |year= 2000 |pmid= 10758170 |doi= 10.1073/pnas.090521697 }}
* {{cite journal | vauthors = Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG | title = Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 14 | pages = 8151–6 | year = 2000 | pmid = 10884437 | pmc = 16685 | doi = 10.1073/pnas.97.14.8151 }}
*{{cite journal | author=Ghanshani S, Wulff H, Miller MJ, ''et al.'' |title=Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. |journal=J. Biol. Chem. |volume=275 |issue= 47 |pages= 37137-49 |year= 2001 |pmid= 10961988 |doi= 10.1074/jbc.M003941200 }}
* {{cite journal | vauthors = Wulff H, Gutman GA, Cahalan MD, Chandy KG | title = Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1 | journal = J. Biol. Chem. | volume = 276 | issue = 34 | pages = 32040–5 | year = 2001 | pmid = 11425865 | doi = 10.1074/jbc.M105231200 }}
*{{cite journal | author=Wulff H, Gutman GA, Cahalan MD, Chandy KG |title=Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 32040-5 |year= 2001 |pmid= 11425865 |doi= 10.1074/jbc.M105231200 }}
* {{cite journal | vauthors = Koegel H, Kaesler S, Burgstahler R, Werner S, Alzheimer C | title = Unexpected down-regulation of the hIK1 Ca2+-activated K+ channel by its opener 1-ethyl-2-benzimidazolinone in HaCaT keratinocytes. Inverse effects on cell growth and proliferation | journal = J. Biol. Chem. | volume = 278 | issue = 5 | pages = 3323–30 | year = 2003 | pmid = 12421833 | doi = 10.1074/jbc.M208914200 }}
*{{cite journal | author=Koegel H, Kaesler S, Burgstahler R, ''et al.'' |title=Unexpected down-regulation of the hIK1 Ca2+-activated K+ channel by its opener 1-ethyl-2-benzimidazolinone in HaCaT keratinocytes. Inverse effects on cell growth and proliferation. |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 3323-30 |year= 2003 |pmid= 12421833 |doi= 10.1074/jbc.M208914200 }}
* {{cite journal | vauthors = Mazzone JN, Kaiser RA, Buxton IL | title = Calcium-activated potassium channel expression in human myometrium: effect of pregnancy | journal = Proc. West. Pharmacol. Soc. | volume = 45 | issue = | pages = 184–6 | year = 2002 | pmid = 12434576 | doi = }}
*{{cite journal | author=Mazzone JN, Kaiser RA, Buxton IL |title=Calcium-activated potassium channel expression in human myometrium: effect of pregnancy. |journal=Proc. West. Pharmacol. Soc. |volume=45 |issue= |pages= 184-6 |year= 2003 |pmid= 12434576 |doi= }}
* {{cite journal | vauthors = Syme CA, Hamilton KL, Jones HM, Gerlach AC, Giltinan L, Papworth GD, Watkins SC, Bradbury NA, Devor DC | title = Trafficking of the Ca2+-activated K+ channel, hIK1, is dependent upon a C-terminal leucine zipper | journal = J. Biol. Chem. | volume = 278 | issue = 10 | pages = 8476–86 | year = 2003 | pmid = 12493744 | doi = 10.1074/jbc.M210072200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Hamilton KL, Syme CA, Devor DC | title = Molecular localization of the inhibitory arachidonic acid binding site to the pore of hIK1 | journal = J. Biol. Chem. | volume = 278 | issue = 19 | pages = 16690–7 | year = 2003 | pmid = 12609997 | doi = 10.1074/jbc.M212959200 }}
*{{cite journal | author=Syme CA, Hamilton KL, Jones HM, ''et al.'' |title=Trafficking of the Ca2+-activated K+ channel, hIK1, is dependent upon a C-terminal leucine zipper. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8476-86 |year= 2003 |pmid= 12493744 |doi= 10.1074/jbc.M210072200 }}
* {{cite journal | vauthors = Mall M, Gonska T, Thomas J, Schreiber R, Seydewitz HH, Kuehr J, Brandis M, Kunzelmann K | title = Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia | journal = Pediatr. Res. | volume = 53 | issue = 4 | pages = 608–18 | year = 2003 | pmid = 12612194 | doi = 10.1203/01.PDR.0000057204.51420.DC }}
*{{cite journal | author=Hamilton KL, Syme CA, Devor DC |title=Molecular localization of the inhibitory arachidonic acid binding site to the pore of hIK1. |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 16690-7 |year= 2003 |pmid= 12609997 |doi= 10.1074/jbc.M212959200 }}
* {{cite journal | vauthors = Hoffman JF, Joiner W, Nehrke K, Potapova O, Foye K, Wickrema A | title = The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 12 | pages = 7366–71 | year = 2003 | pmid = 12773623 | pmc = 165881 | doi = 10.1073/pnas.1232342100 }}
*{{cite journal | author=Mall M, Gonska T, Thomas J, ''et al.'' |title=Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia. |journal=Pediatr. Res. |volume=53 |issue= 4 |pages= 608-18 |year= 2003 |pmid= 12612194 |doi= 10.1203/01.PDR.0000057204.51420.DC }}
* {{cite journal | vauthors = Bernard K, Bogliolo S, Soriani O, Ehrenfeld J | title = Modulation of calcium-dependent chloride secretion by basolateral SK4-like channels in a human bronchial cell line | journal = J. Membr. Biol. | volume = 196 | issue = 1 | pages = 15–31 | year = 2003 | pmid = 14724753 | doi = 10.1007/s00232-003-0621-3 }}
*{{cite journal | author=Hoffman JF, Joiner W, Nehrke K, ''et al.'' |title=The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 12 |pages= 7366-71 |year= 2003 |pmid= 12773623 |doi= 10.1073/pnas.1232342100 }}
* {{cite journal | vauthors = Köhler R, Wulff H, Eichler I, Kneifel M, Neumann D, Knorr A, Grgic I, Kämpfe D, Si H, Wibawa J, Real R, Borner K, Brakemeier S, Orzechowski HD, Reusch HP, Paul M, Chandy KG, Hoyer J | title = Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis | journal = Circulation | volume = 108 | issue = 9 | pages = 1119–25 | year = 2003 | pmid = 12939222 | doi = 10.1161/01.CIR.0000086464.04719.DD }}
*{{cite journal | author=Bernard K, Bogliolo S, Soriani O, Ehrenfeld J |title=Modulation of calcium-dependent chloride secretion by basolateral SK4-like channels in a human bronchial cell line. |journal=J. Membr. Biol. |volume=196 |issue= 1 |pages= 15-31 |year= 2004 |pmid= 14724753 |doi= 10.1007/s00232-003-0621-3 }}
* {{cite journal | vauthors = Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H | title = The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans | journal = J. Clin. Invest. | volume = 118 | issue = 9 | pages = 3025–37 | year = 2008 | pmid = 18688283 | pmc = 2496961 | doi = 10.1172/JCI30836 }}
*{{cite journal | author=Jones HM, Hamilton KL, Papworth GD, ''et al.'' |title=Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 15531-40 |year= 2004 |pmid= 14754884 |doi= 10.1074/jbc.M400069200 }}
* {{cite journal | vauthors = Jones HM, Hamilton KL, Papworth GD, Syme CA, Watkins SC, Bradbury NA, Devor DC | title = Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1 | journal = J. Biol. Chem. | volume = 279 | issue = 15 | pages = 15531–40 | year = 2004 | pmid = 14754884 | doi = 10.1074/jbc.M400069200 }}
*{{cite journal | author=Gibson JS, Muzyamba MC |title=Modulation of Gardos channel activity by oxidants and oxygen tension: effects of 1-chloro-2,4-dinitrobenzene and phenazine methosulphate. |journal=Bioelectrochemistry (Amsterdam, Netherlands) |volume=62 |issue= 2 |pages= 147-52 |year= 2005 |pmid= 15039018 |doi= 10.1016/j.bioelechem.2003.07.008 }}
* {{cite journal | vauthors = Gibson JS, Muzyamba MC | title = Modulation of Gardos channel activity by oxidants and oxygen tension: effects of 1-chloro-2,4-dinitrobenzene and phenazine methosulphate | journal = Bioelectrochemistry | volume = 62 | issue = 2 | pages = 147–52 | year = 2004 | pmid = 15039018 | doi = 10.1016/j.bioelechem.2003.07.008 }}
*{{cite journal  | author=Lew VL, Tiffert T, Etzion Z, ''et al.'' |title=Distribution of dehydration rates generated by maximal Gardos-channel activation in normal and sickle red blood cells. |journal=Blood |volume=105 |issue= 1 |pages= 361-7 |year= 2005 |pmid= 15339840 |doi= 10.1182/blood-2004-01-0125 }}
* {{cite journal | vauthors = Lew VL, Tiffert T, Etzion Z, Perdomo D, Daw N, Macdonald L, Bookchin RM | title = Distribution of dehydration rates generated by maximal Gardos-channel activation in normal and sickle red blood cells | journal = Blood | volume = 105 | issue = 1 | pages = 361–7 | year = 2005 | pmid = 15339840 | doi = 10.1182/blood-2004-01-0125 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
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{{Ion channels}}
{{Ion channels|g3}}
 
[[Category:Ion channels]]
[[Category:Ion channels]]
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Latest revision as of 01:53, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the KCa3.1 protein.[1]

Function

The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.[1]

History

The channel activity was first described in 1958 by György Gárdos in human erythrocytes.[2] The channels is also named Gardos channel because of its discoverer.

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4".
  2. ↑ Gardos G (1958). "The function of calcium in the potassium permeability of human erythrocytes". Biochim. Biophys. Acta. 30 (3): 653–4. doi:10.1016/0006-3002(58)90124-0. PMID 13618284.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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